Fuchs Endothelial Corneal Dystrophy
Abstract Fuchs endothelial corneal dystrophy (FECD) is characterized by progressive loss of corneal endothelial cells, thickening of Descement's membrane and deposition of extracellular matrix in the form of guttae. When the number of endothelial cells becomes critically low, the cornea swells...
Saved in:
Published in | The ocular surface Vol. 8; no. 4; pp. 173 - 184 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.10.2010
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Abstract Fuchs endothelial corneal dystrophy (FECD) is characterized by progressive loss of corneal endothelial cells, thickening of Descement's membrane and deposition of extracellular matrix in the form of guttae. When the number of endothelial cells becomes critically low, the cornea swells and causes loss of vision. The clinical course of FECD usually spans 10-20 years. Corneal transplantation is currently the only modality used to restore vision. Over the last several decades genetic studies have detected several genes, as well as areas of chromosomal loci associated with the disease. Proteomic studies have given rise to several hypotheses regarding the pathogenesis of FECD. This review expands upon the recent findings from proteomic and genetic studies and builds upon recent advances in understanding the causes of this common corneal disorder. |
---|---|
Bibliography: | Authors contributed equally. |
ISSN: | 1542-0124 1937-5913 |
DOI: | 10.1016/S1542-0124(12)70232-X |