Effects of altered glycolysis levels on CD8+ T cell activation and function

• Published in: Cell death & disease Vol. 14; no. 7; pp. 407 - 13
• Main Authors: Cao, Jiaying, Liao, Shan, Zeng, Feng, Liao, Qianjin, Luo, Gengqiu, Zhou, Yanhong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.07.2023; Springer Nature B.V; Nature Publishing Group
• Subjects: 631/250/1933; 631/80/83; Adaptive immunity; Antibodies; Biochemistry; Biomedical and Life Sciences; CD8 antigen; CD8-Positive T-Lymphocytes; Cell activation; Cell Biology; Cell Culture; Cell Differentiation; Cytokines - metabolism; Glycolysis; Immunology; Immunotherapy; Life Sciences; Lymphocyte Activation; Lymphocytes; Lymphocytes T; Recovery of function; Review; Review Article; Senescence
• ISSN: 2041-4889; 2041-4889
• DOI: 10.1038/s41419-023-05937-3

CD8 + T cells are an important component of the body’s adaptive immune response. During viral or intracellular bacterial infections, CD8 + T cells are rapidly activated and differentiated to exert their immune function by producing cytokines. Alterations in the glycolysis of CD8 + T cells have an important effect on their activation and function, while glycolysis is important for CD8 + T cell functional failure and recovery. This paper summarizes the importance of CD8 + T cell glycolysis in the immune system. We discuss the link between glycolysis and CD8 + T cell activation, differentiation, and proliferation, and the effect of altered glycolysis on CD8 + T cell function. In addition, potential molecular targets to enhance and restore the immune function of CD8 + T cells by affecting glycolysis and the link between glycolysis and CD8 + T cell senescence are summarized. This review provides new insights into the relationship between glycolysis and CD8 + T cell function, and proposes novel strategies for immunotherapy by targeting glycolysis.