Exercise Capacity and All-Cause Mortality in Prehypertensive Men

• Published in: American journal of hypertension Vol. 22; no. 7; pp. 735 - 741
• Main Authors: Kokkinos, Peter, Myers, Jonathan, Doumas, Michael, Faselis, Charles, Manolis, Athanasios, Pittaras, Andreas, Kokkinos, John P., Singh, Steven, Fletcher, Ross D.
• Format: Journal Article
• Language: English
• Published: Basingstoke Oxford University Press 01.07.2009; Nature Publishing Group
• Subjects: Adult; Aged; Antihypertensive Agents; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiopathies: etiologic forms (general aspects and miscellaneous); Cohort Studies; Exercise; Exercise Test; Exercise Tolerance; Heart; Humans; Hypertension - epidemiology; Male; Medical sciences; Middle Aged; Mortality; Physical Fitness; Retrospective Studies; Physical exercise; Human; Hypertension; Cardiovascular disease; Mortality
• ISSN: 0895-7061; 1941-7225; 1879-1905
• DOI: 10.1038/ajh.2009.74

Background Prehypertension is associated with increased risk for mortality, a fact that generated a debate regarding the use of antihypertensive therapy in prehypertensives. Increased exercise capacity is associated with lower mortality risk, but little is known about its effects in prehypertensives. Thus, we evaluated the association between exercise capacity and all-cause mortality in prehypertensives. Methods A graded exercise test was performed in 4,478 prehypertensive men at the Veterans Affairs Medical Centers in Washington, DC and Palo Alto, CA. Four fitness categories (quartiles) were defined based on peak metabolic equivalents (METs) achieved. All-cause mortality was assessed for both younger (≤60 years) and older individuals. The mean follow-up period was 9.0 ± 6.0 years. Results Exercise capacity was a strong predictor of all-cause mortality, independent of traditional risk factors. The adjusted risk for all-cause mortality was reduced by 15% for every 1-MET increase in exercise capacity in the entire cohort, 18% for younger and 12% for older individuals. Compared to the Very-Low-Fit individuals (≤6 METs) the adjusted mortality risk was 40% lower in Low-Fit (6.1–8.0 METs); 58% lower in Moderate-Fit (8.1–10 METs), and 73% lower in High-Fit individuals (>10 METs). The trends were similar but more pronounced among younger than older individuals. Conclusions A strong, inverse and graded association between exercise capacity and all-cause mortality was observed in prehypertensive individuals. The protective effects of increased fitness were more pronounced in younger than older individuals, suggesting that age should be more closely considered when assessing fitness and mortality relationships.