Comparative validation of AI and non-AI methods in MRI volumetry to diagnose Parkinsonian syndromes

• Published in: Scientific reports Vol. 13; no. 1; p. 3439
• Main Authors: Song, Joomee, Hahm, Juyoung, Lee, Jisoo, Lim, Chae Yeon, Chung, Myung Jin, Youn, Jinyoung, Cho, Jin Whan, Ahn, Jong Hyeon, Kim, Kyungsu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114/116; 631/114/1305; 631/378/1689/1718; 639/166/985; Atrophy; Basal ganglia; Brain; Central nervous system diseases; Classification; Deep learning; Differential diagnosis; Globus pallidus; Gold; Humanities and Social Sciences; Humans; Image processing; Magnetic Resonance Imaging; Mesencephalon; Movement disorders; multidisciplinary; Neural networks; Neurodegenerative diseases; Neuroimaging; Paralysis; Parkinson Disease; Parkinson's disease; Parkinsonian Disorders; Patients; Pons; Progressive supranuclear palsy; Putamen; Science; Science (multidisciplinary); Segmentation; Ventricle; Ventricles (cerebral)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-30381-w

Automated segmentation and volumetry of brain magnetic resonance imaging (MRI) scans are essential for the diagnosis of Parkinson’s disease (PD) and Parkinson’s plus syndromes (P-plus). To enhance the diagnostic performance, we adopt deep learning (DL) models in brain MRI segmentation and compared their performance with the gold-standard non-DL method. We collected brain MRI scans of healthy controls ( n = 105 ) and patients with PD ( n = 105 ), multiple systemic atrophy ( n = 132 ), and progressive supranuclear palsy ( n = 69 ) at Samsung Medical Center from January 2017 to December 2020. Using the gold-standard non-DL model, FreeSurfer (FS), we segmented six brain structures: midbrain, pons, caudate, putamen, pallidum, and third ventricle, and considered them as annotated data for DL models, the representative convolutional neural network (CNN) and vision transformer (ViT)-based models. Dice scores and the area under the curve (AUC) for differentiating normal, PD, and P-plus cases were calculated to determine the measure to which FS performance can be reproduced as-is while increasing speed by the DL approaches. The segmentation times of CNN and ViT for the six brain structures per patient were 51.26 ± 2.50 and 1101.82 ± 22.31 s, respectively, being 14 to 300 times faster than FS (15,735 ± 1.07 s). Dice scores of both DL models were sufficiently high (> 0.85) so their AUCs for disease classification were not inferior to that of FS. For classification of normal vs. P-plus and PD vs. P-plus (except multiple systemic atrophy - Parkinsonian type) based on all brain parts, the DL models and FS showed AUCs above 0.8, demonstrating the clinical value of DL models in addition to FS. DL significantly reduces the analysis time without compromising the performance of brain segmentation and differential diagnosis. Our findings may contribute to the adoption of DL brain MRI segmentation in clinical settings and advance brain research.