The effect of dapagliflozin on uric acid excretion and serum uric acid level in advanced CKD

• Published in: Scientific reports Vol. 13; no. 1; p. 4849
• Main Authors: Iwata, Yukimasa, Notsu, Shoki, Kawamura, Yushi, Mitani, Waka, Tamai, Shinjiro, Morimoto, Madoka, Yamato, Masafumi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.03.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 692/163; 692/4022/1585/104; Aged; Antidiabetics; Benzhydryl Compounds - pharmacology; Benzhydryl Compounds - therapeutic use; Diabetes; Diabetes mellitus; Excretion; Female; Glomerular Filtration Rate; Glucosides - pharmacology; Glucosides - therapeutic use; Humanities and Social Sciences; Humans; Kidney diseases; Male; multidisciplinary; Multiple regression analysis; Renal Insufficiency, Chronic - drug therapy; Science; Science (multidisciplinary); Sodium-glucose cotransporter; Uric Acid

Sodium–glucose cotransporter 2 inhibitors (SGLT2i) exhibit renoprotective effect in patients with chronic kidney disease (CKD) and reduce serum uric acid (UA) in patients with diabetes mellitus. However, it is not clarified whether SGLT2i reduce serum UA levels in patients with advanced CKD. This st...