The effect of dapagliflozin on uric acid excretion and serum uric acid level in advanced CKD

• Published in: Scientific reports Vol. 13; no. 1; p. 4849
• Main Authors: Iwata, Yukimasa, Notsu, Shoki, Kawamura, Yushi, Mitani, Waka, Tamai, Shinjiro, Morimoto, Madoka, Yamato, Masafumi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.03.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 692/163; 692/4022/1585/104; Aged; Antidiabetics; Benzhydryl Compounds - pharmacology; Benzhydryl Compounds - therapeutic use; Diabetes; Diabetes mellitus; Excretion; Female; Glomerular Filtration Rate; Glucosides - pharmacology; Glucosides - therapeutic use; Humanities and Social Sciences; Humans; Kidney diseases; Male; multidisciplinary; Multiple regression analysis; Renal Insufficiency, Chronic - drug therapy; Science; Science (multidisciplinary); Sodium-glucose cotransporter; Uric Acid
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-32072-y

Sodium–glucose cotransporter 2 inhibitors (SGLT2i) exhibit renoprotective effect in patients with chronic kidney disease (CKD) and reduce serum uric acid (UA) in patients with diabetes mellitus. However, it is not clarified whether SGLT2i reduce serum UA levels in patients with advanced CKD. This study aimed to investigate the impact of SGLT2i on change in serum UA levels in patients with advanced CKD. Data of 121 Japanese patients with CKD who were newly administered 10 mg dapagliflozin in our department between August 2021 and August 2022 were analyzed. Changes in UA and fractional excretion of UA (FEUA) were analyzed using multiple regression analysis. Of 75 patients, 21 (28.0%) patients, 24 (32.0%) patients, 29 (38.7%) patients, and 1 (1.3%) patient were categorized as having CKD stage 3a, 3b, 4, and 5, respectively. The median age was 67 years, and 72.0% were male. 23 (30.7%) of patients had diabetes mellitus. The median estimated glomerular filtration rate, serum UA, and FEUA were 35.7 mL/min/1.73 m 2 , 6.4 mg/dL, and 6.76%, respectively, at the time of dapagliflozin administration. After administration, serum UA decreased to 5.6 mg/dL and FEUA increased to 9.22%. Dapagliflozin increases FEUA and reduces serum UA levels in patients with advanced CKD.