Surface functionalization of acrylic based photocrosslinkable resin for 3D printing applications

• Published in: Bioactive materials Vol. 2; no. 3; pp. 131 - 137
• Main Authors: Ronca, A., Maiullari, F., Milan, M., Pace, V., Gloria, A., Rizzi, R., De Santis, R., Ambrosio, L.
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.09.2017; KeAi Publishing; KeAi Communications Co., Ltd
• ISSN: 2452-199X; 2452-199X
• DOI: 10.1016/j.bioactmat.2017.04.002

The limited number of resins, available for stereolithography applications, is one of the key drivers in research applied to rapid prototyping. In this work an acrylic photocrosslinkable resin based on methyl methacrylate (MMA), butyl methacrylate (BMA) and poly(ethylene glycol) dimethacrylate (PEGDA) was developed with different composition and characterized in terms of mechanical, thermal and biological behaviour. Two different systems have been developed using different amount of reagent. The influence of every components have been evaluated on the final characteristic of the resin in order to optimize the final composition for applications in bone tissue engineering. The crosslinked materials showed good mechanical properties and thermal stabilities and moreover cytotoxicity test confirms good biocompatibility with no cytotoxic effect on cells metabolism. Moreover two different treatments have been proposed, using fetal bovine serum (FBS) and methanol (MeOH), in order to improve cell recognition of the surfaces. Samples threatened with MeOH allow cell adhesion and survival, promoting spreading, elongation and fusion of C2C12 muscle myoblast cells. [Display omitted] •Photocrosslinkable biocompatible resin for application in tissue engineering.•Surface treatment to improve materials wettability.•Myoblast spreading and elongation on photocrosslinked modified surfaces.