PRODUCTION OF NOVEL ANTIBIOTIC, DOPSISAMINE, BY A NEW SUBSPECIES OF NOCARDIOPSIS MUTABILIS WITH MULTIPLE ANTIBIOTIC RESISTANCE

• Published in: Journal of antibiotics Vol. 39; no. 2; pp. 175 - 183
• Main Authors: TAKAHASHI, ATSUSHI, HOTTAN, KUNIMOTO, SAITO, ORIKO, MORIOKA, MOTO, OKAMI, YOSHIRO, UMEZAWA, HAMAO
• Format: Journal Article
• Language: English
• Published: Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1986; Japan Antibiotics Research Association
• Subjects: Actinomycetales - classification; Actinomycetales - drug effects; Actinomycetales - metabolism; Aminoglycosides - pharmacology; Anti-Bacterial Agents - biosynthesis; Anti-Bacterial Agents - pharmacology; Antibiotics; Biological and medical sciences; Biotechnology; Chemical Phenomena; Chemistry; Drug Resistance, Microbial; Fundamental and applied biological sciences. Psychology; General pharmacology; Health. Pharmaceutical industry; Industrial applications and implications. Economical aspects; Magnetic Resonance Spectroscopy; Medical sciences; Pharmacology. Drug treatments; Physicochemical properties. Structure-activity relationships; Polyamines - biosynthesis; Polyamines - pharmacology; Production of active biomolecules; Antibiotic; Taxonomy; Production; Bacteria; Isolation; Fermentation; Biological activity; Physicochemical properties
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.39.175

An actinomycete isolate designated as TS-1980 with multiple resistance to aminoglycoside antibiotics was found to produce novel antibiotics. The strain showed taxonomic features identical to the type strain of Nocardiopsis mutabilis except for the temperature range for growth and the utilization of mannitol and raffinose. Based on the capability of growing at lower temperature range, the strain was named N. mutabilis subsp. cryophilis subsp. nov. Physico-chemical and biological characterization of a purified antibiotic revealed its novel polyamine-type nature with a broad antimicrobial activity. The antibiotic was named dopsisamine.