Toward hemodynamic diagnosis of carotid artery stenosis based on ultrasound image data and computational modeling

• Published in: Medical & biological engineering & computing Vol. 52; no. 11; pp. 971 - 983
• Main Authors: Sousa, Luísa C., Castro, Catarina F., António, Carlos C., Santos, André Miguel F., dos Santos, Rosa Maria, Castro, Pedro Miguel A. C., Azevedo, Elsa, Tavares, João Manuel R. S.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2014; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Analysis; Asymptomatic; Atherosclerosis; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Carotid arteries; Carotid Arteries - diagnostic imaging; Carotid Stenosis - diagnostic imaging; Computer Applications; Data analysis; Female; Finite Element Analysis; Fluid dynamics; Geometry; Hemodynamics; Hemodynamics - physiology; Hospitals; Human Physiology; Humans; Image Processing, Computer-Assisted - methods; Imaging; Magnetic resonance imaging; Male; Medical imaging; Middle Aged; Models, Cardiovascular; Morphology; Original Article; Pathophysiology; Patients; Radiology; Shear stress; Spectrum analysis; Studies; Three dimensional imaging; Ultrasonic imaging; Ultrasonography, Doppler; Veins & arteries; Finite element method; Carotid artery bifurcation; Computational hemodynamics; Image-based analysis; 3D reconstruction; WSS descriptors
• ISSN: 0140-0118; 1741-0444
• DOI: 10.1007/s11517-014-1197-z

The ability of using non-expensive ultrasound (US) image data together with computer fluid simulation to access various severities of carotid stenosis was inquired in this study. Subject-specific hemodynamic conditions were simulated using a developed finite element solver. Individual structured meshing of the common carotid artery (CCA) bifurcation was built from segmented longitudinal and cross-sectional US images; imposed boundary velocities were based on Doppler US measurements. Simulated hemodynamic parameters such as velocities, wall shear stress (WSS) and derived descriptors were able to predict disturbed flow conditions which play an important role in the development of local atherosclerotic plaques. Hemodynamic features from six individual CCA bifurcations were analyzed. High values of time-averaged WSS (TAWSS) were found at stenosis site. Low values of TAWSS were found at the bulb and at the carotid internal and external branches depending on the particular features of each patient. High oscillating shear index and relative residence time values assigned highly disturbed flows at the same artery surface regions that correlate only moderately with low TAWSS results. Based on clinic US examinations, results provide estimates of flow changes and forces at the carotid artery wall toward the link between hemodynamic behavior and stenosis pathophysiology.