Identification of INHBA as a potential biomarker for gastric cancer through a comprehensive analysis

• Published in: Scientific reports Vol. 13; no. 1; p. 12494
• Main Authors: Liu, Fang, Liu, Jiayi, Shi, Xinrui, Hu, Xiaojie, Wei, Lai, Huo, Bingjie, Chang, Liang, Han, Yaqing, Liu, Guangjie, Yang, Lei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/67; 631/67/580; 631/67/69; B-Lymphocytes - metabolism; Biomarkers; Biomarkers, Tumor - metabolism; CD8 antigen; Dendritic cells; DNA methylation; Gastric cancer; Gene set enrichment analysis; Humanities and Social Sciences; Humans; Immunotherapy; Infiltration; Inhibin; Leukocytes (neutrophilic); Lymphocytes T; Macrophages; Metastases; Methylation; multidisciplinary; Prognosis; Science; Science (multidisciplinary); Stomach Neoplasms - diagnosis; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; Transforming growth factor-b
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-39784-1

Inhibin subunit beta A (INHBA) is a member of the transforming growth factor-beta (TGF-β) superfamily that plays a fundamental role in various cancers. However, a systematic analysis of the exact role of INHBA in patients with gastric cancer (GC) has not yet been conducted. We evaluated the expression levels of INHBA and the correlation between INHBA and GC prognosis in GC. The relationship between INHBA expression, immune infiltration levels, and type markers of immune cells in GC was also explored. In addition, we studied INHBA mutations, promoter methylation, and functional enrichment analysis. Besides, high expression levels of INHBA in GC were significantly related to unfavorable prognosis. INHBA was negatively correlated with B cell infiltration, but positively correlated with macrophage and most anticancer immunity steps. INHBA expression was positively correlated with the type markers of CD8+ T cells, neutrophils, macrophages, and dendritic cells. INHBA has a weak significant methylation level change between tumor and normal tissues and mainly enriched in cancer-related signaling pathways. The present study implies that INHBA may serve as a potential biomarker for predicting the prognosis of patients with GC. INHBA is a promising predictor of immunotherapy response, with higher levels of INHBA indicating greater sensitivity.