Enhanced bone regenerative properties of calcium phosphate ceramic granules in rabbit posterolateral spinal fusion through a reduction of grain size

• Published in: Bioactive materials Vol. 11; pp. 90 - 106
• Main Authors: Li, Xiangfeng, Zhou, Quan, Wu, Yonghao, Feng, Cong, Yang, Xi, Wang, Linnan, Xiao, Yumei, Zhang, Kai, Zhu, Xiangdong, Liu, Limin, Song, Yueming, Zhang, Xingdong
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.05.2022; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: Calcium phosphate ceramics; Nanotopography; Osteogenic differentiation; Osteoinductivity; Posterolateral spinal fusion; Nanotopography; Posterolateral spinal fusion; Calcium phosphate ceramics; Osteogenic differentiation; Osteoinductivity
• ISSN: 2452-199X; 2452-199X
• DOI: 10.1016/j.bioactmat.2021.10.006

Osteoinductivity is a crucial factor to determine the success and efficiency of posterolateral spinal fusion (PLF) by employing calcium phosphate (Ca-P) bioceramics. In this study, three kinds of Ca-P ceramics with microscale to nanoscale gain size (BCP-control, BCP-micro and BCP-nano) were prepared and their physicochemical properties were characterized. BCP-nano had the spherical shape and nanoscale gain size, BCP-micro had the spherical shape and microscale gain size, and BCP-control (BAM®) had the irregular shape and microscale gain size. The obtained BCP-nano with specific nanotopography could well regulate in vitro protein adsorption and osteogenic differentiation of MC3T3 cells. In vivo rabbit PLF procedures further confirmed that nanotopography of BCP-nano might be responsible for the stronger bone regenerative ability comparing with BCP-micro and BCP-control. Collectedly, due to nanocrystal similarity with natural bone apatite, BCP-nano has excellent efficacy in guiding bone regeneration of PLF, and holds great potentials to become an alternative to standard bone grafts for future clinical applications. [Display omitted] •The nanocrystal of porous BCP ceramic spheres is similar to natural bone apatite.•BCP nanoceramics is conducive to protein adsorption and osteogenic differentiation of MC3T3 cells.•Osteoindutivity of BCP ceramics is a crucial factor to determine the sucess and efficiency of PLF.•BCP ceramic spheres with nanotopography hold great potential in clinical PLF applications.