Clinical and radiomics feature-based outcome analysis in lumbar disc herniation surgery

• Published in: BMC musculoskeletal disorders Vol. 24; no. 1; pp. 1 - 791
• Main Authors: Saravi, Babak, Zink, Alisia, Ülkümen, Sara, Couillard-Despres, Sebastien, Wollborn, Jakob, Lang, Gernot, Hassel, Frank
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 06.10.2023; BioMed Central; BMC
• Subjects: Algorithms; Artificial Intelligence; Care and treatment; Clinical outcomes; Deep learning; Discectomy; Endoscopy; Hernia; Hospitals; Intervertebral discs; Intervertebral disk; Intervertebral disk displacement; Learning algorithms; Length of stay; Low back pain; Lumbar disc herniation; Machine learning; Magnetic resonance imaging; Methods; Musculoskeletal diseases; Neural networks; Patient outcomes; Patients; Postoperative period; Prognosis; Radiomics; Software; Surgeons; Surgery; Surgical techniques; Treatment outcome; Variables; Germany
• ISSN: 1471-2474; 1471-2474
• DOI: 10.1186/s12891-023-06911-y

Abstract Background Low back pain is a widely prevalent symptom and the foremost cause of disability on a global scale. Although various degenerative imaging findings observed on magnetic resonance imaging (MRI) have been linked to low back pain and disc herniation, none of them can be considered pathognomonic for this condition, given the high prevalence of abnormal findings in asymptomatic individuals. Nevertheless, there is a lack of knowledge regarding whether radiomics features in MRI images combined with clinical features can be useful for prediction modeling of treatment success. The objective of this study was to explore the potential of radiomics feature analysis combined with clinical features and artificial intelligence-based techniques (machine learning/deep learning) in identifying MRI predictors for the prediction of outcomes after lumbar disc herniation surgery. Methods We included n = 172 patients who underwent discectomy due to disc herniation with preoperative T2-weighted MRI examinations. Extracted clinical features included sex, age, alcohol and nicotine consumption, insurance type, hospital length of stay (LOS), complications, operation time, ASA score, preoperative CRP, surgical technique (microsurgical versus full-endoscopic), and information regarding the experience of the performing surgeon (years of experience with the surgical technique and the number of surgeries performed at the time of surgery). The present study employed a semiautomatic region-growing volumetric segmentation algorithm to segment herniated discs. In addition, 3D-radiomics features, which characterize phenotypic differences based on intensity, shape, and texture, were extracted from the computed magnetic resonance imaging (MRI) images. Selected features identified by feature importance analyses were utilized for both machine learning and deep learning models (n = 17 models). Results The mean accuracy over all models for training and testing in the combined feature set was 93.31 ± 4.96 and 88.17 ± 2.58. The mean accuracy for training and testing in the clinical feature set was 91.28 ± 4.56 and 87.69 ± 3.62. Conclusions Our results suggest a minimal but detectable improvement in predictive tasks when radiomics features are included. However, the extent of this advantage should be considered with caution, emphasizing the potential of exploring multimodal data inputs in future predictive modeling.