Impaired empathy and increased anger following social exclusion in non-intoxicated opioid users

• Published in: Psychopharmacology Vol. 237; no. 2; pp. 419 - 430
• Main Authors: Carlyle, Molly, Rowley, Megan, Stevens, Tobias, Karl, Anke, Morgan, Celia J. A.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2020; Springer; Springer Nature B.V
• Subjects: Adult; Aged; Analgesics, Opioid - adverse effects; Anger; Anger - physiology; Biomedical and Life Sciences; Biomedicine; Cognitive ability; Corticosteroids; Drug addiction; Emotions; Empathy; Empathy - physiology; Female; Heart beat; Heart rate; Humans; Hydrocortisone; Hydrocortisone - metabolism; Hyperalgesia; Male; Middle Aged; Mood; Narcotics; Neurosciences; Opiate Substitution Treatment - psychology; Opiate Substitution Treatment - trends; Opioid-Related Disorders - metabolism; Opioid-Related Disorders - psychology; Opioids; Original Investigation; Pain perception; Pharmacology/Toxicology; Photic Stimulation - methods; Physiological aspects; Physiology; Psychiatry; Psychological Distance; Social exclusion; Social interactions; User groups; Young Adult; Empathy; Cortisol; Addiction; Social pain; Opioids; Social cognition
• ISSN: 0033-3158; 1432-2072
• DOI: 10.1007/s00213-019-05378-x

Rationale Social functioning is modulated by the endogenous opioid system. In opioid use disorder, social functioning appears disrupted, but little research has delineated the nature of these deficits and their relationship to acute opioid use. Objectives The current study aimed to assess both emotional and cognitive empathy, along with subjective and physiological responses to social exclusion in opioid users who were either acutely intoxicated or non-intoxicated from using opioids. Methods Individuals on an opioid substitution medication (OSM) were divided into ‘intoxicated users’ (had taken their OSM the same day as testing, n = 20) and ‘non-intoxicated users’ (had taken their OSM > 12 h ago, n = 20) and compared with opioid-naïve controls ( n = 24). Empathy was assessed using the multifaceted empathy test and self-report questionnaire. Participants also underwent a period of social exclusion (Cyberball Game) and completed measures of mood and physiological responses (salivary cortisol and heart rate). Results Non-intoxicated users had significantly lower emotional empathy (the ability to experience others’ emotions), as well as greater anger after social exclusion when compared with the intoxicated users and controls. Anger did not change with social exclusion in the intoxicated user group and cortisol levels were lower overall. Conclusions Reduced ability to spontaneously share the emotions of others was reported in non-intoxicated users, particularly regarding positive emotions. There was some support for the idea of hyperalgesia to social pain, but this was restricted to an enhanced anger response in non-intoxicated users. Equivalent rates of empathy between the intoxicated users and controls could indicate some remediating effects of acute opioids.