Neuronal travelling waves explain rotational dynamics in experimental datasets and modelling

• Published in: Scientific reports Vol. 14; no. 1; pp. 3566 - 15
• Main Authors: Kuzmina, Ekaterina, Kriukov, Dmitrii, Lebedev, Mikhail
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.02.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/116/2393; 631/378/2632; 631/378/2632/1663; Datasets; Decision making; Dynamical systems; Humanities and Social Sciences; multidisciplinary; Muscle function; Neurons; Neurosciences; Science; Science (multidisciplinary)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-53907-2

Spatiotemporal properties of neuronal population activity in cortical motor areas have been subjects of experimental and theoretical investigations, generating numerous interpretations regarding mechanisms for preparing and executing limb movements. Two competing models, representational and dynamical, strive to explain the relationship between movement parameters and neuronal activity. A dynamical model uses the jPCA method that holistically characterizes oscillatory activity in neuron populations by maximizing the data rotational dynamics. Different rotational dynamics interpretations revealed by the jPCA approach have been proposed. Yet, the nature of such dynamics remains poorly understood. We comprehensively analyzed several neuronal-population datasets and found rotational dynamics consistently accounted for by a traveling wave pattern. For quantifying rotation strength, we developed a complex-valued measure, the gyration number. Additionally, we identified parameters influencing rotation extent in the data. Our findings suggest that rotational dynamics and traveling waves are typically the same phenomena, so reevaluation of the previous interpretations where they were considered separate entities is needed.