Nanoparticles advanced from preclinical studies to clinical trials for lung cancer therapy

Lung cancer is the leading cause of cancer mortality. As a heterogeneous disease, it has different subtypes and various treatment modalities. In addition to conventional surgery, radiotherapy and chemotherapy, targeted therapy and immunotherapy have also been applied in the clinics. However, drug re...

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Published inCancer nanotechnology Vol. 14; no. 1; p. 28
Main Authors Liu, Yifan, Cheng, Wenxu, Xin, HongYi, Liu, Ran, Wang, Qinqi, Cai, Wenqi, Peng, Xiaochun, Yang, Fuyuan, Xin, HongWu
Format Journal Article
LanguageEnglish
Published Vienna Springer Vienna 2023
Springer Nature B.V
BMC
Subjects
Anticancer properties
Biochemistry
Biomedical Engineering and Bioengineering
Cancer Research
Cancer therapies
Chemistry and Materials Science
Clinical trials
Dendrimers
Drug delivery systems
Immune targeted therapy
Immunotherapy
Lung cancer
Materials Science
Nanoparticle
Nanoparticles
Nanotechnology
Nanotherapy
Physical properties
Quantum dots
Radiation therapy
Review
Toxicity
Immune targeted therapy
Nanoparticle
Lung cancer
Nanotherapy
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Summary:Lung cancer is the leading cause of cancer mortality. As a heterogeneous disease, it has different subtypes and various treatment modalities. In addition to conventional surgery, radiotherapy and chemotherapy, targeted therapy and immunotherapy have also been applied in the clinics. However, drug resistance and systemic toxicity still cannot be avoided. Based on the unique properties of nanoparticles, it provides a new idea for lung cancer therapy, especially for targeted immunotherapy. When nanoparticles are used as carriers of drugs with special physical properties, the nanodrug delivery system ensures the accuracy of targeting and the stability of drugs while increasing the permeability and the aggregation of drugs in tumor tissues, showing good anti-tumor effects. This review introduces the properties of various nanoparticles including polymer nanoparticles, liposome nanoparticles, quantum dots, dendrimers, and gold nanoparticles and their applications in tumor tissues. In addition, the specific application of nanoparticle-based drug delivery for lung cancer therapy in preclinical studies and clinical trials is discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1868-6958
1868-6966
DOI:10.1186/s12645-023-00174-x