Moving closer towards a comprehensive view of tumor biology and microarchitecture using spatial transcriptomics

Spatial transcriptomic profiling of cancer has enabled spatial delineation of malignant transcriptional heterogeneity, intercellular communication, and organization of microanatomical structures within the tumor microenvironment. This technical breakthrough paves the way for the development of preci...

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Bibliographic Details
Published inNature communications Vol. 14; no. 1; p. 7017
Main Authors Park, Young Min, Lin, De-Chen
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 02.11.2023
Nature Publishing Group
Nature Portfolio
Subjects
631/67/327
631/67/69
692/4028/67/69
Biology
Breast cancer
Comment
Ecosystem biology
Fibroblasts
Gene expression
Gene Expression Profiling
Heterogeneity
Humanities and Social Sciences
Humans
Hypoxia
Lymphocytes
Medical research
Melanoma
Metabolism
multidisciplinary
Neoplasms - genetics
Science
Science (multidisciplinary)
Skin cancer
T cell receptors
Transcriptome
Transcriptomics
Tumor microenvironment
Tumors
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Summary:Spatial transcriptomic profiling of cancer has enabled spatial delineation of malignant transcriptional heterogeneity, intercellular communication, and organization of microanatomical structures within the tumor microenvironment. This technical breakthrough paves the way for the development of precision diagnostic methods and targeted therapies.
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-023-42960-6