Non-lytic expulsion/exocytosis of Candida albicans from macrophages

Candida albicans is an opportunistic pathogen and is recognised and phagocytosed by macrophages. Using live-cell imaging, non-lytic expulsion/exocytosis of C. albicans from macrophages is demonstrated for the first time. Following complete expulsion, both the phagocyte and pathogen remain intact and...

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Published inFungal genetics and biology Vol. 49; no. 9; pp. 677 - 678
Main Authors Bain, Judith M., Lewis, Leanne E., Okai, Blessing, Quinn, Janet, Gow, Neil A.R., Erwig, Lars-Peter
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.09.2012
Academic Press
Subjects
Candida albicans
Candida albicans - growth & development
Candida albicans - immunology
Candidiasis - immunology
Candidiasis - microbiology
Exocytosis
Fungal infection
Humans
hyphae
Hyphae - growth & development
Hyphae - immunology
image analysis
Innate immunology
Macrophage
macrophages
Macrophages - immunology
Macrophages - microbiology
pathogens
Phagocytosis
Video
Candida albicans
Innate immunology
Phagocytosis
Fungal infection
Macrophage
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Summary:Candida albicans is an opportunistic pathogen and is recognised and phagocytosed by macrophages. Using live-cell imaging, non-lytic expulsion/exocytosis of C. albicans from macrophages is demonstrated for the first time. Following complete expulsion, both the phagocyte and pathogen remain intact and viable. Partial engulfment of hyphal C. albicans without macrophage lysis is also demonstrated. These observations underpin the complexity of interactions between C. albicans and innate immune cells.
Bibliography:http://dx.doi.org/10.1016/j.fgb.2012.01.008
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These authors contributed equally to this work.
ISSN:1087-1845
1096-0937
DOI:10.1016/j.fgb.2012.01.008