Role of IgG avidity in eyes with active Toxoplasma retinochoroiditis

• Published in: Indian journal of ophthalmology Vol. 72; no. Suppl 4; pp. S601 - S605
• Main Authors: Lakhmawar, Pratik, Kelgaonkar, Anup, Patel, Anamika, Khalsa, Ashish, Basu, Soumyava
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer - Medknow 01.07.2024; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Edition: 2
• Subjects: Adolescent; Adult; Antibodies, Protozoan - blood; Antibodies, Protozoan - immunology; Antibody Affinity; Avidity; Child; Chorioretinitis - diagnosis; Chorioretinitis - immunology; Chorioretinitis - parasitology; Disseminated infection; Eye Infections, Parasitic - diagnosis; Eye Infections, Parasitic - immunology; Eye Infections, Parasitic - parasitology; Female; Follow-Up Studies; Humans; Immunoglobulin G; Immunoglobulin G - blood; Immunoglobulin G - immunology; Immunoglobulin M; Immunoglobulin M - blood; Immunoglobulin M - immunology; Male; Middle Aged; Original; Original Article; Retinochoroiditis; Retrospective Studies; Serology; Toxoplasma; Toxoplasma - immunology; toxoplasma igg; toxoplasma igg avidity; toxoplasma igm; toxoplasma retinochoroiditis; toxoplasma serology; Toxoplasmosis; Toxoplasmosis, Ocular - diagnosis; Toxoplasmosis, Ocular - immunology; Toxoplasmosis, Ocular - parasitology; Young Adult; Toxoplasma retinochoroiditis; Toxoplasma serology; Toxoplasma IgM; Toxoplasma IgG avidity; Toxoplasma IgG
• ISSN: 0301-4738; 1998-3689; 1998-3689
• DOI: 10.4103/IJO.IJO_3000_23

Purpose: To study the role of Toxoplasma IgG avidity in evaluating the stage of systemic infection during manifestation as toxoplasma retinochoroiditis and its clinical implications in eastern India. Methods: Retrospective chart review of Toxoplasma retinochoroiditis cases with Toxoplasma serology for IgG, IgM, and IgG avidity. Results: Included in this study were 17 eyes of 17 patients who had active retinitis located in the macula (14), mid-periphery (2), or periphery (1). They were either primary lesions (12) or reactivations (5). All the cases had Toxoplasma IgG positive; one case had IgM positivity, while all the cases had high IgG avidity values. IgG avidity had a positive correlation with the duration of symptoms. Conclusion: We observed high IgG avidity values in active retinochoroiditis in both primary ocular Toxoplasmosis and reactivation subgroups. These results indicate a late ocular manifestation after initial systemic infection with a possible incubation period ranging from 5 weeks to 5 months.