How can we establish animal models of HIV‐associated lymphoma?

• Published in: Animal models and experimental medicine Vol. 7; no. 4; pp. 484 - 496
• Main Authors: Xiao, Qing, Zhai, Liuyue, Zhang, Xiaomei, Liu, Yi, Li, Jun, Xie, Xiaoqing, Xu, Guofa, He, Sanxiu, Fu, Huihui, Tang, Yifeng, Zhang, Fujie, Liu, Yao
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.08.2024; John Wiley and Sons Inc; Wiley
• Subjects: Acquired immune deficiency syndrome; AIDS; animal model; Animal models; Animals; Cancer; Cells; Disease Models, Animal; HIV; HIV Infections - complications; HIV‐associated lymphoma (HAL); Human immunodeficiency virus; human immunodeficiency virus (HIV); Humans; Immune system; immunodeficient mice; Immunomodulation; Lymphatic system; Lymphocytes; Lymphoma; Lymphoma - etiology; Lymphoma - virology; Lymphoma, AIDS-Related; Malignancy; Mice; Nervous system; primate model; Proteins; Regular; Review; Transgenic animals; Viruses; immunodeficient mice; HIV‐associated lymphoma (HAL); human immunodeficiency virus (HIV); animal model; primate model
• ISSN: 2576-2095; 2096-5451; 2576-2095
• DOI: 10.1002/ame2.12409

Human immunodeficiency virus (HIV) infection is strongly associated with a heightened incidence of lymphomas. To mirror the natural course of human HIV infection, animal models have been developed. These models serve as valuable tools to investigate disease pathobiology, assess antiretroviral and immunomodulatory drugs, explore viral reservoirs, and develop eradication strategies. However, there are currently no validated in vivo models of HIV‐associated lymphoma (HAL), hampering progress in this crucial domain, and scant attention has been given to developing animal models dedicated to studying HAL, despite their pivotal role in advancing knowledge. This review provides a comprehensive overview of the existing animal models of HAL, which may enhance our understanding of the underlying pathogenesis and approaches for malignancies linked to HIV infection. This review provides a comprehensive overview of the existing animal models of HAL, which may enhance our understanding of the underlying pathogenesis and approaches for malignancies linked to HIV infection.