Clinical translation of cell-based pharmacogenomic discovery

The use of cell-based models has emerged as a promising means to discover and validate pharmacologic phenotype-genotype relationships. The availability of large-scale genome studies in both human and model systems is now allowing us an unprecedented opportunity to understand how well cell-based mode...

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Bibliographic Details
Published inClinical pharmacology and therapeutics Vol. 92; no. 4; p. 425
Main Authors Cox, N J, Gamazon, E R, Wheeler, H E, Dolan, M E
Format Journal Article
LanguageEnglish
Published United States 01.10.2012
Subjects
Animals
Cell Line, Tumor
Drug Discovery - methods
Drug Discovery - trends
Genomics - methods
Genomics - trends
Humans
Pharmacogenetics - methods
Pharmacogenetics - trends
Polymorphism, Single Nucleotide - genetics
Translational Research, Biomedical - methods
Translational Research, Biomedical - trends
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Summary:The use of cell-based models has emerged as a promising means to discover and validate pharmacologic phenotype-genotype relationships. The availability of large-scale genome studies in both human and model systems is now allowing us an unprecedented opportunity to understand how well cell-based models identify clinically relevant genetic variants associated with drug response and toxicity. Here we review these studies and the emerging translational information.
ISSN:1532-6535
DOI:10.1038/clpt.2012.115