New era of emerging preoperative chemotherapy in gastrointestinal cancer

The effect of neoadjuvant chemotherapy has been associated with increased expression of immune checkpoint molecules, such as PD-1, and tumor infiltrating lymphocytes profiles representing high CD8/FOXP3 ratio but has not been associated with genomic alterations in new generation sequence (NGS). [......

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Bibliographic Details
Published inAnnals of gastroenterological surgery Vol. 8; no. 2; pp. 188 - 189
Main Author Yamashita, Keishi
Format Journal Article
LanguageEnglish
Published Japan John Wiley & Sons, Inc 01.03.2024
John Wiley and Sons Inc
Wiley
Subjects
Awards & honors
Cancer therapies
Chemotherapy
Colorectal cancer
Conflicts of interest
Gastric cancer
Medical prognosis
Metastasis
Missing data
Multivariate analysis
Success
Surgeons
Surgery
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Summary:The effect of neoadjuvant chemotherapy has been associated with increased expression of immune checkpoint molecules, such as PD-1, and tumor infiltrating lymphocytes profiles representing high CD8/FOXP3 ratio but has not been associated with genomic alterations in new generation sequence (NGS). [...]rectal cancer may be expected to be susceptible to combined immunotherapy with chemotherapy. [...]preoperative chemotherapy could be utilized even as an excellent research tool to clarify the treatment response of clinical cancer cells. [...]Nakagawa et al. have reported effects of neoadjuvant chemotherapy for patients with highly conditional colon cancer (obstructive cases) in multicenter propensity score-matched analysis (YCOG2101).
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:2475-0328
2475-0328
DOI:10.1002/ags3.12785