Dying to Defend: Neutrophil Death Pathways and their Implications in Immunity

Neutrophils, accounting for ≈70% of human peripheral leukocytes, are key cells countering bacterial and fungal infections. Neutrophil homeostasis involves a balance between cell maturation, migration, aging, and eventual death. Neutrophils undergo different death pathways depending on their interact...

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Published inAdvanced science Vol. 11; no. 8; pp. e2306457 - n/a
Main Authors Tu, Haiyue, Ren, Haoyu, Jiang, Junjie, Shao, Changshun, Shi, Yufang, Li, Peishan
Format Journal Article
LanguageEnglish
Published Germany John Wiley & Sons, Inc 01.02.2024
Wiley
Subjects
Aging
Apoptosis
Bone marrow
Cell death
Cell Differentiation
Cell division
Cytochrome
Cytoplasm
Cytotoxicity
Dendritic cells
Disease
Ferroptosis
Granulocytes
Homeostasis
Humans
Inflammation
Kinases
Leukocytes
necroptosis
NETosis
neutrophil apoptosis
Neutrophils
Pathogens
Physiology
pyroptosis
Tumor necrosis factor-TNF
pyroptosis
NETosis
ferroptosis
neutrophil apoptosis
necroptosis
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Summary:Neutrophils, accounting for ≈70% of human peripheral leukocytes, are key cells countering bacterial and fungal infections. Neutrophil homeostasis involves a balance between cell maturation, migration, aging, and eventual death. Neutrophils undergo different death pathways depending on their interactions with microbes and external environmental cues. Neutrophil death has significant physiological implications and leads to distinct immunological outcomes. This review discusses the multifarious neutrophil death pathways, including apoptosis, NETosis, pyroptosis, necroptosis, and ferroptosis, and outlines their effects on immune responses and disease progression. Understanding the multifaceted aspects of neutrophil death, the intersections among signaling pathways and ramifications of immunity will help facilitate the development of novel therapeutic methods. This review discusses the multifarious neutrophil death pathways, including apoptosis, NETosis, pyroptosis, necroptosis, and ferroptosis, and outlines their effects on immune responses and disease progression. Understanding the multifaceted aspects of neutrophil death, the intersections among signaling pathways and ramifications of immunity will help facilitate the development of novel therapeutic methods.
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ISSN:2198-3844
2198-3844
DOI:10.1002/advs.202306457