Complex Investigation of the Effects of Lambertianic Acid Amide in Female Mice under Conditions of Social Discomfort

The effects of chronic administration of a new substance lambertianic acid amide and previously synthesized methyl ester of this acid were compared in female mice living under conditions of social discomfort. For modeling social discomfort, female mouse was housed for 30 days in a cage with aggressi...

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Published inBulletin of experimental biology and medicine Vol. 157; no. 5; pp. 583 - 587
Main Authors Avgustinovich, D. F., Fomina, M. K., Sorokina, I. V., Tolstikova, T. G.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.09.2014
Springer
Springer Nature B.V
Subjects
Amides - chemistry
Animals
Biomedical and Life Sciences
Biomedicine
Blood Glucose - analysis
Blood Proteins - analysis
Carboxylic Acids - chemistry
Carboxylic Acids - pharmacology
Cell Biology
Cholesterol - blood
Enzyme-Linked Immunosorbent Assay
Female
Internal Medicine
Laboratory Medicine
Male
Mice
Naphthalenes - chemistry
Naphthalenes - pharmacology
Pathology
Social Behavior Disorders - prevention & control
Triglycerides - blood
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Summary:The effects of chronic administration of a new substance lambertianic acid amide and previously synthesized methyl ester of this acid were compared in female mice living under conditions of social discomfort. For modeling social discomfort, female mouse was housed for 30 days in a cage with aggressive male mouse kept behind a transparent perforated partition and observed its confrontations with another male mouse daily placed to the cage. The new agent more effectively than lambertianic acid methyl ester improved communicativeness and motor activity of animals, reduced hypertrophy of the adrenal glands, and enhanced catalase activity in the blood. These changes suggest that lambertianic acid amide produces a pronounced stress-protective effect under conditions of social discomfort.
Bibliography:ObjectType-Article-1
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2621-y