DNA G-quadruplex and its potential as anticancer drug target

G-quadruplex secondary structures are four-stranded globular nucleic acid structures form in the specific DNA and RNA G-rich sequences with biological significance such as human telomeres, oncogene-promoter regions, replication initiation sites, and 5′ and 3′-untranslated (UTR) regions. The non-cano...

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Bibliographic Details
Published inScience China. Chemistry Vol. 57; no. 12; pp. 1605 - 1614
Main Authors Onel, Buket, Lin, Clement, Yang, DanZhou
Format Journal Article
LanguageEnglish
Published Heidelberg Science China Press 01.12.2014
Springer Nature B.V
Subjects
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Deoxyribonucleic acid
DNA
Gene sequencing
Nucleic acids
Reviews
human telomeres
anticancer drug target
oncogene promoters
G-quadruplex-targeted small molecules
DNA G-quadruplexes
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Summary:G-quadruplex secondary structures are four-stranded globular nucleic acid structures form in the specific DNA and RNA G-rich sequences with biological significance such as human telomeres, oncogene-promoter regions, replication initiation sites, and 5′ and 3′-untranslated (UTR) regions. The non-canonical G-quadruplex secondary structures can readily form under physiologically relevant ionic conditions and are considered to be new molecular target for cancer therapeutics. This review discusses the essential progress in our lab related to the structures and functions of biologically relevant DNA G-quadruplexes in human gene promoters and telomeres, and the opportunities presented for the development of G-quadruplex-targeted small-molecule drugs.
ISSN:1674-7291
1869-1870
1862-2771
DOI:10.1007/s11426-014-5235-3