Exploring the role of the posterior middle temporal gyrus in semantic cognition: Integration of anterior temporal lobe with executive processes

• Published in: NeuroImage (Orlando, Fla.) Vol. 137; pp. 165 - 177
• Main Authors: Davey, James, Thompson, Hannah E., Hallam, Glyn, Karapanagiotidis, Theodoros, Murphy, Charlotte, De Caso, Irene, Krieger-Redwood, Katya, Bernhardt, Boris C., Smallwood, Jonathan, Jefferies, Elizabeth
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.08.2016; Elsevier Limited; Academic Press
• Subjects: Adolescent; Adult; Brain Mapping - methods; Brain research; Cognition; Cognition & reasoning; Cognition - physiology; Concept Formation - physiology; Cortex (frontal); Cortex (temporal); Default mode network; Executive Function - physiology; Female; Frontal gyrus; Humans; Information processing; Integration; Intraparietal sulcus; Male; Memory retrieval; Mental Recall - physiology; Multidemand network; Nerve Net - physiology; Neural networks; Neuroimaging; Posterior middle temporal gyrus; Semantic control; Semantics; Structure-function relationships; Systematic review; Task Performance and Analysis; Temporal gyrus; Temporal lobe; Temporal Lobe - physiology; Transcranial magnetic stimulation; Verbal Learning - physiology; Young Adult; Posterior middle temporal gyrus; Memory retrieval; Default mode network; Semantic control; Multidemand network
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2016.05.051

Making sense of the world around us depends upon selectively retrieving information relevant to our current goal or context. However, it is unclear whether selective semantic retrieval relies exclusively on general control mechanisms recruited in demanding non-semantic tasks, or instead on systems specialised for the control of meaning. One hypothesis is that the left posterior middle temporal gyrus (pMTG) is important in the controlled retrieval of semantic (not non-semantic) information; however this view remains controversial since a parallel literature links this site to event and relational semantics. In a functional neuroimaging study, we demonstrated that an area of pMTG implicated in semantic control by a recent meta-analysis was activated in a conjunction of (i) semantic association over size judgements and (ii) action over colour feature matching. Under these circumstances the same region showed functional coupling with the inferior frontal gyrus — another crucial site for semantic control. Structural and functional connectivity analyses demonstrated that this site is at the nexus of networks recruited in automatic semantic processing (the default mode network) and executively demanding tasks (the multiple-demand network). Moreover, in both task and task-free contexts, pMTG exhibited functional properties that were more similar to ventral parts of inferior frontal cortex, implicated in controlled semantic retrieval, than more dorsal inferior frontal sulcus, implicated in domain-general control. Finally, the pMTG region was functionally correlated at rest with other regions implicated in control-demanding semantic tasks, including inferior frontal gyrus and intraparietal sulcus. We suggest that pMTG may play a crucial role within a large-scale network that allows the integration of automatic retrieval in the default mode network with executively-demanding goal-oriented cognition, and that this could support our ability to understand actions and non-dominant semantic associations, allowing semantic retrieval to be ‘shaped’ to suit a task or context. [Display omitted] •Posterior middle temporal gyrus supports semantic control and event semantics.•pMTG is at nexus of the default mode and multiple-demand networks.•It links anterior temporal and prefrontal regions for representation and control.•pMTG connects with inferior frontal gyrus during tasks and at rest.•These sites form a semantic control network distinct from executive control.