Extracellular vesicle-derived miR-320a targets ZC3H12B to inhibit tumorigenesis, invasion, and angiogenesis in ovarian cancer

• Published in: Discover. Oncology Vol. 12; no. 1; p. 51
• Main Authors: Huang, Yan, Xu, Midie, Jing, Chuyu, Wu, Xiaohua, Chen, Xiaojun, Zhang, Wei
• Format: Journal Article
• Language: English
• Published: New York Springer US 17.11.2021; Springer Nature B.V; Springer
• Subjects: Amino acids; Angiogenesis; Antibiotics; Biomarkers; Cancer Research; Cell culture; Extracellular vesicles; Gene expression; Internal Medicine; Medical prognosis; Medicine; Medicine & Public Health; Metastasis; miR-320a; Molecular Medicine; Oncology; Ovarian cancer; Proteins; Radiotherapy; Surgical Oncology; Tumorigenesis; ZC3H12B; United States > US; Japan; Germany; Extracellular vesicles; miR-320a; Tumorigenesis; ZC3H12B; Ovarian cancer
• ISSN: 2730-6011; 2730-6011
• DOI: 10.1007/s12672-021-00437-2

Extracellular vesicles (EVs) play crucial roles in intercellular communication. miRNAs derived from EVs emerge as promising diagnostic indicators and therapeutic targets in a variety of malignancies. Tremendous studies have revealed the function of miRNAs derived from EVs in tumorigenesis, metastasis and other aspects. The mechanism of action of EV-derived miRNAs, however, in ovarian cancer remains largely unknown. In this study, EVs were enriched from the ovarian cancer cell lines. EVs as a whole could promote cell proliferation, invasion and new vasculature formation. However, the down-regulated EV-derived miR-320a was demonstrated to potentially suppress tumorigenesis, metastasis and angiogenesis. Moreover, EV-derived miR-320a has been proved to directly regulate a previously unknown target, ZC3H12B. An unreported role of ZC3H12B in promoting ovarian cancer cell proliferation has been elucidated and miR-320a could mediate the expression of ZC3H12B, thereby inhibiting the downstream response. As for the practical clinic values, lower expression of EV-derived miR-320a correlates with shorter survival period, indicating that EV-derived miR-320a may also serve as a prognostic biomarker in ovarian cancer. This research provides new insight into the molecular mechanism of EV-derived miR-320a in ovarian cancer and may provide new therapeutic and prognostic strategies for ovarian cancer treatment.