Long-lasting renewable antibacterial porous polymeric coatings enable titanium biomaterials to prevent and treat peri-implant infection

• Published in: Nature communications Vol. 12; no. 1; p. 3303
• Main Authors: Wu, Shuyi, Xu, Jianmeng, Zou, Leiyan, Luo, Shulu, Yao, Run, Zheng, Bingna, Liang, Guobin, Wu, Dingcai, Li, Yan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.06.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/22; 639/301/54; 639/301/54/993; 639/638/263; Amines - administration & dosage; Amines - chemistry; Amines - pharmacology; Animal models; Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial materials; Bacteria; Biocides; Biocompatibility; Biofilms - drug effects; Biofilms - growth & development; Biomaterials; Biomedical materials; Coated Materials, Biocompatible - administration & dosage; Coated Materials, Biocompatible - chemistry; Coated Materials, Biocompatible - pharmacology; Coatings; Dental Implants; Dental materials; Dental prosthetics; Drug Stability; Humanities and Social Sciences; Humans; In Vitro Techniques; Infections; Male; Materials Testing; multidisciplinary; Oral cavity; Osseointegration; Osseointegration - drug effects; Peri-Implantitis - microbiology; Peri-Implantitis - prevention & control; Peri-Implantitis - therapy; Polymer coatings; Porosity; Rabbits; Science; Science (multidisciplinary); Surface Properties; Titanium; Titanium - administration & dosage; Titanium - chemistry; Titanium - pharmacology
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-021-23069-0

Peri-implant infection is one of the biggest threats to the success of dental implant. Existing coatings on titanium surfaces exhibit rapid decrease in antibacterial efficacy, which is difficult to promisingly prevent peri-implant infection. Herein, we report an N-halamine polymeric coating on titanium surface that simultaneously has long-lasting renewable antibacterial efficacy with good stability and biocompatibility. Our coating is powerfully biocidal against both main pathogenic bacteria of peri-implant infection and complex bacteria from peri-implantitis patients. More importantly, its antibacterial efficacy can persist for a long term (e.g., 12~16 weeks) in vitro, in animal model, and even in human oral cavity, which generally covers the whole formation process of osseointegrated interface. Furthermore, after consumption, it can regain its antibacterial ability by facile rechlorination, highlighting a valuable concept of renewable antibacterial coating in dental implant. These findings indicate an appealing application prospect for prevention and treatment of peri-implant infection. Infection is a major problem for dental implants with current antibacterial coatings losing efficacy quickly. Here, the authors report on the N-halamine polymeric coating of titanium implants to create a long-lasting renewable antibacterial layer and demonstrate application in vivo.