Molecular implications of HOX genes targeting multiple signaling pathways in cancer

Homeobox ( HOX ) genes encode highly conserved homeotic transcription factors that play a crucial role in organogenesis and tissue homeostasis. Their deregulation impacts the function of several regulatory molecules contributing to tumor initiation and progression. A functional bridge exists between...

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Published inCell biology and toxicology Vol. 38; no. 1; pp. 1 - 30
Main Authors Shenoy, U Sangeetha, Adiga, Divya, Kabekkodu, Shama Prasada, Hunter, Keith D, Radhakrishnan, Raghu
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.02.2022
Springer Nature B.V
Subjects
Biochemistry
Biomarkers
Biomedical and Life Sciences
Cancer
Carcinogenesis - genetics
Cell Biology
Cell Transformation, Neoplastic - genetics
Deregulation
Gene expression
Genes
Genes, Homeobox - genetics
Homeobox
Homeostasis
HOX gene
Humans
Life Sciences
Medical diagnosis
Metastases
Neoplasms - metabolism
Organogenesis
Pharmacology/Toxicology
Review
Signal transduction
Signal Transduction - genetics
Signaling
Transcription factors
Tumorigenesis
Signaling pathways
Diagnostic and prognostic significance
Metastasis
genes
Cancer
HOX genes
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Abstract Homeobox ( HOX ) genes encode highly conserved homeotic transcription factors that play a crucial role in organogenesis and tissue homeostasis. Their deregulation impacts the function of several regulatory molecules contributing to tumor initiation and progression. A functional bridge exists between altered gene expression of individual HOX genes and tumorigenesis. This review focuses on how deregulation in the HOX-associated signaling pathways contributes to the metastatic progression in cancer. We discuss their functional significance, clinical implications and ascertain their role as a diagnostic and prognostic biomarker in the various cancer types. Besides, the mechanism of understanding the theoretical underpinning that affects HOX -mediated therapy resistance in cancers has been outlined. The knowledge gained shall pave the way for newer insights into the treatment of cancer. Graphical abstract
AbstractList Homeobox ( HOX ) genes encode highly conserved homeotic transcription factors that play a crucial role in organogenesis and tissue homeostasis. Their deregulation impacts the function of several regulatory molecules contributing to tumor initiation and progression. A functional bridge exists between altered gene expression of individual HOX genes and tumorigenesis. This review focuses on how deregulation in the HOX-associated signaling pathways contributes to the metastatic progression in cancer. We discuss their functional significance, clinical implications and ascertain their role as a diagnostic and prognostic biomarker in the various cancer types. Besides, the mechanism of understanding the theoretical underpinning that affects HOX -mediated therapy resistance in cancers has been outlined. The knowledge gained shall pave the way for newer insights into the treatment of cancer. Graphical abstract
Homeobox (HOX) genes encode highly conserved homeotic transcription factors that play a crucial role in organogenesis and tissue homeostasis. Their deregulation impacts the function of several regulatory molecules contributing to tumor initiation and progression. A functional bridge exists between altered gene expression of individual HOX genes and tumorigenesis. This review focuses on how deregulation in the HOX-associated signaling pathways contributes to the metastatic progression in cancer. We discuss their functional significance, clinical implications and ascertain their role as a diagnostic and prognostic biomarker in the various cancer types. Besides, the mechanism of understanding the theoretical underpinning that affects HOX-mediated therapy resistance in cancers has been outlined. The knowledge gained shall pave the way for newer insights into the treatment of cancer.
Homeobox (HOX) genes encode highly conserved homeotic transcription factors that play a crucial role in organogenesis and tissue homeostasis. Their deregulation impacts the function of several regulatory molecules contributing to tumor initiation and progression. A functional bridge exists between altered gene expression of individual HOX genes and tumorigenesis. This review focuses on how deregulation in the HOX-associated signaling pathways contributes to the metastatic progression in cancer. We discuss their functional significance, clinical implications and ascertain their role as a diagnostic and prognostic biomarker in the various cancer types. Besides, the mechanism of understanding the theoretical underpinning that affects HOX-mediated therapy resistance in cancers has been outlined. The knowledge gained shall pave the way for newer insights into the treatment of cancer.Homeobox (HOX) genes encode highly conserved homeotic transcription factors that play a crucial role in organogenesis and tissue homeostasis. Their deregulation impacts the function of several regulatory molecules contributing to tumor initiation and progression. A functional bridge exists between altered gene expression of individual HOX genes and tumorigenesis. This review focuses on how deregulation in the HOX-associated signaling pathways contributes to the metastatic progression in cancer. We discuss their functional significance, clinical implications and ascertain their role as a diagnostic and prognostic biomarker in the various cancer types. Besides, the mechanism of understanding the theoretical underpinning that affects HOX-mediated therapy resistance in cancers has been outlined. The knowledge gained shall pave the way for newer insights into the treatment of cancer.
Homeobox ( HOX ) genes encode highly conserved homeotic transcription factors that play a crucial role in organogenesis and tissue homeostasis. Their deregulation impacts the function of several regulatory molecules contributing to tumor initiation and progression. A functional bridge exists between altered gene expression of individual HOX genes and tumorigenesis. This review focuses on how deregulation in the HOX-associated signaling pathways contributes to the metastatic progression in cancer. We discuss their functional significance, clinical implications and ascertain their role as a diagnostic and prognostic biomarker in the various cancer types. Besides, the mechanism of understanding the theoretical underpinning that affects HOX -mediated therapy resistance in cancers has been outlined. The knowledge gained shall pave the way for newer insights into the treatment of cancer.
Author Adiga, Divya
Hunter, Keith D
Shenoy, U Sangeetha
Radhakrishnan, Raghu
Kabekkodu, Shama Prasada
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  organization: Department of Oral Pathology, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34617205$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/j.prp.2020.153117
10.1158/0008-5472.CAN-09-2189
10.21147/j.issn.1000-9604.2017.06.12
10.1158/1078-0432.CCR-18-0444
10.1038/s41419-018-0497-x
10.1039/C5MB00253B
10.1038/sj.onc.1205126
10.1158/0008-5472.CAN-03-2614
10.1038/s41375-018-0361-0
10.1007/s12253-017-0243-1
10.1158/0008-5472.CAN-06-0458
10.1159/000134320
10.3390/cancers12113299
10.1038/sj.onc.1210056
10.1182/blood-2011-07-328880
10.1016/j.bbrc.2018.08.071
10.1186/s12882-019-1322-1
10.1158/0008-5472.CAN-13-1178
10.1158/0008-5472.CAN-16-2797
10.1038/nrc2826
10.1002/gcc.10139
10.3390/jcm8091500
10.1166/ch.2013.1007
10.3727/096504017X14900530835262
10.2147/OTT.S196986
10.3390/cells9071613
10.1186/s12885-016-2106-7
10.3892/mmr.2015.4331
10.3892/ijo.2013.1935
10.1038/onc.2013.404
10.1186/s13148-019-0634-0
10.1186/s13148-017-0412-9
10.1073/pnas.1920860117
10.1186/s12943-019-0955-9
10.1016/j.leukres.2015.04.012
10.1016/j.cell.2011.02.013
10.1016/j.canep.2013.03.003
10.1007/s11914-014-0241-0
10.1016/j.ejso.2019.12.009
10.1016/j.stem.2016.05.003
10.2147/OTT.S234829
10.3892/ijo.2012.1660
10.1111/1440-1681.13278
10.1101/gr.700503
10.1620/tjem.234.209
10.1126/scitranslmed.3008326
10.1590/1806-9282.66.6.794
10.4143/crt.2016.106
10.1038/s41598-019-46064-4
10.1074/jbc.M116.772780
10.18632/oncotarget.14216
10.1371/journal.pone.0130551
10.1016/j.dld.2018.08.018
10.1155/2017/3680305
10.1097/CAD.0000000000000948
10.1016/j.ydbio.2005.10.032
10.1016/j.lfs.2018.12.011
10.1172/JCI62229
10.1158/1078-0432.CCR-10-2533
10.1016/j.ejphar.2019.04.004
10.1073/pnas.1102300108
10.1038/s41389-017-0016-4
10.7150/thno.52199
10.18632/oncotarget.1306
10.1038/labinvest.2017.107
10.1158/0008-5472.CAN-16-0774
10.1172/JCI39104
10.1002/jez.b.21021
10.1152/ajpcell.00238.2015
10.1016/j.canlet.2017.09.019
10.1016/j.tig.2017.11.007
10.3389/fonc.2020.00368
10.1002/1878-0261.12155
10.1089/gtmb.2017.0240
10.1158/2159-8290.CD-17-0583
10.1038/nm.2609
10.1038/bjc.2015.233
10.1016/j.ymgme.2013.10.012
10.1007/s00239-010-9396-1
10.1053/j.gastro.2009.08.065
10.1002/cbin.11568
10.1038/sj.bjc.6602631
10.7150/thno.27310
10.1038/35016125
10.1002/mc.22793
10.1074/jbc.M112.361675
10.1186/s12885-020-07088-6
10.1016/j.cell.2007.05.022
10.1007/s10620-014-3033-6
10.1002/wdev.78
10.1016/j.ebiom.2017.09.029
10.1371/journal.pone.0124191
10.1016/j.cell.2013.08.015
10.1038/sj.onc.1210180
10.1002/jcp.27036
10.3892/ijo.2016.3738
10.1038/s41598-018-31030-3
10.1016/j.febslet.2014.02.005
10.15171/apb.2019.024
10.1002/humu.20155
10.1245/s10434-019-07166-5
10.1038/onc.2013.30
10.2147/CMAR.S209904
10.1002/hep.26740
10.1002/jcb.25496
10.4103/sjg.SJG_105_18
10.7314/APJCP.2015.16.9.3941
10.3390/cancers13010010
10.7314/APJCP.2016.17.3.1037
10.1111/1759-7714.12758
10.3389/fonc.2019.00394
10.3892/or.2015.4085
10.1186/1471-2407-12-348
10.1016/j.molmed.2016.03.002
10.1038/cddis.2013.84
10.1152/ajpcell.00291.2017
10.1093/neuonc/nov281
10.1016/j.prp.2018.09.001
10.1073/pnas.0912710107
10.7150/jca.38728
10.1242/dev.109785
10.1042/BJ20150213
10.1126/science.1085753
10.1073/pnas.1018859108
10.1186/1475-2867-6-10
10.1111/febs.14476
10.1002/ijc.33494
10.1186/s12964-018-0316-0
10.1128/MCB.24.2.924-935.2004
10.1016/j.biocel.2017.04.011
10.1186/s13046-017-0559-4
10.7150/jca.18893
10.1186/s13046-018-0941-x
10.1158/2159-8290.CD-12-0095
10.1158/0008-5472.CAN-14-3100
10.1074/jbc.M110.183251
10.1371/journal.pone.0236811
10.1007/s10147-020-01772-0
10.1111/1759-7714.13142
10.1007/s00508-016-1108-4
10.1126/scisignal.2004088
10.1016/j.bbrc.2018.05.019
10.1080/1061186X.2018.1473408
10.1016/j.ydbio.2014.07.004
10.1007/s13277-014-2909-6
10.1002/jcb.27423
10.1046/j.1432-0436.2003.7108004.x
10.1038/35047605
10.18632/oncotarget.4813
10.1016/0959-437X(95)80031-X
10.1002/ijc.32984
10.1159/000489249
10.1101/cshperspect.a006098
10.1128/MCB.22.9.3157-3173.2002
10.3389/fonc.2020.01152
10.1039/C8RA06860G
10.18632/oncotarget.17004
10.1007/s13277-016-5356-8
10.1245/s10434-012-2252-3
10.18632/oncotarget.3150
10.1007/s10585-012-9524-y
10.1186/s41016-018-0132-9
10.1007/s10238-014-0276-7
10.1186/s13148-017-0373-z
10.1038/s41580-018-0080-4
10.1186/s13059-018-1492-3
10.3390/cancers11040528
10.1186/1479-5876-10-91
10.1387/ijdb.180162sg
10.15171/apb.2017.041
10.2147/vhrm.2006.2.3.213
10.18632/aging.103824
10.1210/en.2007-1320
10.5483/BMBRep.2018.51.9.020
10.2147/OTT.S161109
10.3892/or.2015.4194
10.1002/jcla.22873
10.3390/cells8111360
10.1038/s41419-020-2629-3
10.1056/NEJMoa1110000
10.21873/cgp.20026
10.1038/s41392-020-0134-x
10.18632/oncotarget.13604
10.1016/j.trecan.2020.02.007
10.1038/cr.2009.5
10.1186/s13046-016-0294-2
10.1155/2018/3569493
10.1387/ijdb.180192sz
10.1007/s00427-015-0518-z
10.1016/j.ccell.2015.11.001
10.1002/mc.22180
10.1158/1055-9965.EPI-15-0247
10.1007/s00432-020-03259-x
10.1038/s41388-019-1013-1
10.1007/s13277-014-2988-4
10.1038/leu.2010.270
10.1186/s12935-018-0717-6
10.7150/thno.41712
10.3390/cancers11040512
10.1016/j.ccell.2016.10.019
10.7150/ijbs.11431
10.1002/mc.21947
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IEDL.DBID 7X7
ISSN 0742-2091
1573-6822
IngestDate Thu Aug 21 14:07:42 EDT 2025
Fri Jul 11 01:17:56 EDT 2025
Wed Aug 13 05:12:43 EDT 2025
Mon Jul 21 06:04:33 EDT 2025
Tue Jul 01 02:08:58 EDT 2025
Thu Apr 24 23:02:04 EDT 2025
Fri Feb 21 02:47:26 EST 2025
IsDoiOpenAccess true
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Issue 1
Keywords Signaling pathways
Diagnostic and prognostic significance
Metastasis
genes
Cancer
HOX genes
Language English
License 2021. The Author(s).
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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content type line 14
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ORCID 0000-0003-0088-4777
OpenAccessLink https://link.springer.com/10.1007/s10565-021-09657-2
PMID 34617205
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crossref_primary_10_1007_s10565_021_09657_2
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  year: 2022
  text: 2022-02-01
  day: 01
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PublicationSubtitle An International Journal Devoted to Research at the Cellular Level
PublicationTitle Cell biology and toxicology
PublicationTitleAbbrev Cell Biol Toxicol
PublicationTitleAlternate Cell Biol Toxicol
PublicationYear 2022
Publisher Springer Netherlands
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References Hu, Ou-Yang, Jing, Chen (CR69) 2019; 65
Mohankumar, Perry, Kannan, Kohno, Gluckman, Emerald (CR125) 2008; 149
Arce, Yokoyama, Waterman (CR8) 2006; 25
Shields, Slape, Vo, Jackson, Pliego-Zamora, Ranasinghe (CR165) 2019; 33
Botti, De, Di, Malzone, Collina, Cantile (CR13) 2018; 234
Morgan, Simpson, Gray, Gillett, Tabi, Spicer (CR128) 2016; 16
Brumatti, Salmanidis, Kok, Bilardi, Sandow, Silke (CR14) 2013; 4
Marra, Cantile, Scognamiglio, Perdonà, La Mantia, Cerrone (CR118) 2013; 20
Shah, Sukumar (CR160) 2010; 10
Paço, de Bessa, Garcia, Leitão Castro, Costa-Pinto, Freitas (CR134) 2020; 13
Xia, Tan, Zhou, Lin, Wang, Oyang (CR201) 2018; 11
Zhao, Tan, Ruan, Wei, Zheng, Zheng (CR228) 2015; 16
Li, Jia, Wang, Li, Xie (CR94) 2015; 12
Zhang, Li, Zhang (CR224) 2018; 26
Dongre, Weinberg (CR36) 2019; 20
Sever, Brugge (CR158) 2015; 5
Nakayama, Shibazaki, Yashima-Abo, Miura, Sugiyama, Masuda (CR129) 2013; 43
Li, Wu, Mai, Zhen, Li, Chen (CR101) 2019; 120
Mohankumar, Xu, Zhu, Kannan, Miller, Liu (CR124) 2007; 26
Yuan, Sun, Jiao, Shu, Zhang (CR219) 2018; 22
Guo, Pan, Liu, Shen, Xu, Hu (CR56) 2020; 19
Bhan, Mandal (CR10) 2015; 1856
Liu, Jin, Hui, Fu, Jie, Feng (CR108) 2015; 75
Liang, Wang, Li, Cao, Feng, You (CR105) 2018; 4
Guo, Hou, Ao, Deng, Lyu (CR52) 2017; 29
Chong, Jeon, Han, Son, Lee, Hong (CR24) 2017; 14
Chen, Fan, Xu, Chen, Xu, Wei (CR20) 2016; 31
Syed (CR179) 2016; 117
Pan, Jia, Yao, Sun, Ren, Huang (CR136) 2014; 234
Weiss, Marques, Woltering, Vlecken, Aghdassi, Partecke (CR199) 2009; 137
Wang, Wang, Liu, Hou, Xiao, Wang (CR192) 2019; 33
Shi, Shen, Dong, Fu, Kang, Dai (CR164) 2018; 9
Wang, Yu, Wang (CR193) 2019; 41
Weiner, Faisal, Davicioni, Karnes, Vander, Lotan (CR198) 2020; 12
Beebe-Dimmer, Hathcock, Yee, Okoth, Ewing, Isaacs (CR9) 2015; 24
Guo, Peng, Gao, Zhang, Yang, Linghu (CR53) 2017; 9
Li, Wang, Liu, Wang (CR104) 2020; 66
Li, Shen, Yan, Dong, Kang, Dai (CR93) 2015; 10
Li, Huang, Wei (CR99) 2019; 11
Liu, Zhang, Xu, Zhang, Zou, Yang (CR110) 2018; 7
Cantile, Scognamiglio, Anniciello, Farina, Gentilcore, Santonastaso (CR15) 2012; 10
Zhong, Zhang, Ma, Ren, Xu, Wan (CR230) 2019; 218
Wasenang, Chaiyarit, Proungvitaya, Limpaiboon (CR195) 2019; 11
Huan, Yang, Wen, Chen, Zhang, Wu (CR70) 2017; 36
Peng, Zha, Chen, Wang (CR140) 2018; 40
Smith, Sen, Weeks, Eccles, Chatterjee (CR171) 2020; 6
Kim, Bae, Kim, Song, Kim, Kim (CR83) 2019; 42
Ko, Barengo, Ladanyi, Lee, Marini, Lengyel (CR86) 2012; 122
Xiong, Yin, Gao, Yuan (CR202) 2020; 13
Pojo, Gonçalves, Xavier-Magalhães, Oliveira, Gonçalves, Correia (CR143) 2015; 6
Qin, Chen, Weng, Li, Rong, Zhou (CR144) 2019; 12
Bhatlekar, Fields, Boman (CR11) 2018; 2018
Chiang, Cabrera, Segall (CR23) 2016; 311
Nishida, Yano, Nishida, Kamura, Kojiro (CR130) 2006; 2
Fares, Fares, Khachfe, Salhab, Fares (CR39) 2020; 5
Zhao, Yang, Park (CR229) 2020; 25
Taminiau, Draime, Tys, Lambert, Vandeputte, Nguyen (CR181) 2016; 44
Yuan, Wang, Lai, Zhong, Liang, Yan (CR220) 2019; 17
Xu, Lamouille, Derynck (CR203) 2009; 19
Mallo (CR115) 2018; 34
Wang, Xu, Wang, Sun, Sun, He (CR190) 2017; 8
Li, Cui, Zou, Zhu, Wei (CR102) 2020; 19
Malek, Gajula, Williams, Nghiem, Simons, Nugent (CR114) 2017; 77
Raman, Martensen, Reisman, Evron, Odenwald, Jaffee (CR149) 2000; 405
Han, Song, Wang, Tang, Peng, Lu (CR57) 2018; 57
Lee, Hur, Yun, Kim, Yang, Kim (CR89) 2015; 11
Quagliata, Matter, Piscuoglio, Arabi, Ruiz, Procino (CR146) 2014; 59
Haria, Naora (CR60) 2013; 1
Jin, Kong, Shah, Penet, Wildes, Sgroi (CR77) 2012; 109
Wang, Su, Chen, Chang, Shen, Hsieh (CR187) 2015; 10
Cui, Yan, Zhang, Xue, Zhang, Ma (CR29) 2020; 146
Qu, Zhong, Zheng, Zhao (CR145) 2017; 21
He, Liu, Xia, Xu, Lv, Wang (CR62) 2017; 8
Liao, Jiang, Yuan, Cui, Shi, Chen (CR106) 2011; 17
Su, Zhang, Luo (CR175) 2020; 47
Zhang, Wu, He, Liang, Yi, Shi (CR226) 2019; 51
Zhang, Zhang, Li, Zhang, Zhao (CR227) 2020; 224
Li, Ye, Zhou (CR103) 2020; 10
Miwa, Kanda, Umeda, Tanaka, Tanaka, Kobayashi (CR121) 2019; 26
Ma, Cui, Zheng (CR113) 2020; 11
Feng, Li, Liu, Shi, Peng (CR40) 2015; 11
Shah, Wang, Bei, Platanias, Eklund (CR161) 2011; 286
Cheng, Qian, Huang, Wei, Fu, Du (CR22) 2018; 9
Ohuchida, Mizumoto, Lin, Yamaguchi, Ohtsuka, Sato (CR132) 2012; 19
Zhang, Deng, Zhang, Zhai, He, Hu (CR223) 2017; 10
Gao, Fei, Kong, Tan (CR47) 2020; 31
Kmita, Duboule (CR85) 2003; 301
Cerami, Gao, Dogrusoz, Gross, Sumer, Aksoy (CR17) 2012; 2
Costa, Smith, Chen, Chen, Phillips, Aldape (CR27) 2010; 70
Xuan, Huang, Liu, Ding, Yang, Cui (CR207) 2016; 18
Sadik, Korangath, Nguyen, Gyorffy, Kumar, Hedayati (CR153) 2016; 76
Duan, Han, Wang, Wei, Chen, Zhang (CR37) 2015; 6
Curradi, Izzo, Badaracco, Landsberger (CR31) 2002; 22
Zhou, Li, Li, Liu, Ye, Wu (CR231) 2019; 33
Smith, Zyoud, Allegrucci (CR170) 2019; 11
Liu, Zhu, Yuan, Zhang, Guo, Lin (CR109) 2015; 36
Zhuang, Li, Li, Mao, Gao, Zhang (CR233) 2015; 29
Panagopoulos, Isaksson, Billström, Strömbeck, Mitelman, Johansson (CR137) 2003; 36
Tsuboi, Taniuchi, Shimizu, Saito, Saibara (CR185) 2017; 292
de Barros, Lima Bueno, Ramão, Pinheiro, Alves, Kannen, Jungbluth (CR33) 2016; 37
Liu, Ge, Ma, Zhang, Zhao, Cui (CR111) 2019; 18
Shaoqiang, Yue, Yang, Hong, Lina, Da (CR163) 2013; 30
Holland (CR64) 2013; 2
van Scherpenzeel, Remacle, Picard, Cornu, Gofflot, Rezsohazy (CR186) 2005; 25
Yao, Chen, Nguyen, Thompson, Eroshkin, Nerlakanti (CR215) 2019; 9
He, Chen, Li, Yang, Zeng, Cui (CR63) 2019; 20
Liu, Lu, Wang, Sun, Zhang, Yang (CR107) 2012; 12
Ying, Wang, Huang, Sun, Zhang, Li (CR216) 2020; 39
Giancotti (CR49) 2014; 588
Cui, Zhang, Li, Ma, Cao, Guan (CR30) 2021; 45
Sun, Ge, Ren, Sun, Xie (CR177) 2018; 8
Li, Li, Xiong, Tian, Ru (CR97) 2019; 17
Huang, Chen, Guo (CR72) 2018; 15
Sarno, Cerrone, Gigantino, Scognamiglio, Cantile, Botti (CR155) 2020; 13
Cildir, Low, Tergaonkar (CR25) 2016; 22
Cui, Qin, Zhang, Su, Liu, Wang (CR28) 2014; 59
Ewing, Ray, Lange, Zuhlke, Robbins, Tembe (CR38) 2012; 366
Wang, Liu, Shen, Ye, Huang, Jiao (CR188) 2015; 34
Wardwell-Ozgo, Dogruluk, Gifford, Zhang, Heffernan, van Doorn (CR194) 2014; 33
Sigismund, Avanzato, Lanzetti (CR167) 2018; 12
Yuan, Zhu, Han, Song, Liu, Lu (CR218) 2016; 35
Paço, de Bessa Garcia, Freitas (CR135) 2020; 9
Storti, Donofrio, Colla, Airoldi, Bolzoni, Agnelli (CR173) 2011; 25
Song, Pineault, Dones, Raines, Wellik (CR172) 2020; 117
Hombría, Lovegrove (CR65) 2003; 71
Shah, Jin, Cruz, Park, Sadik, Cho (CR162) 2013; 73
Gao, Aksoy, Dogrusoz, Dresdner, Gross, Sumer (CR46) 2013; 6
Hyman, Kauraniemi, Hautaniemi, Wolf, Mousses, Rozenblum (CR75) 2002; 62
Rezsohazy, Saurin, Maurel-Zaffran, Graba (CR150) 2015; 142
Quagliata, Quintavalle, Lanzafame, Matter, Novello, di Tommaso (CR147) 2018; 98
Montagut, Dalmases, Bellosillo, Crespo, Pairet, Iglesias (CR126) 2012; 18
Thomas, Snowden, Zeidler, Danson (CR184) 2015; 113
Yang, Kang, Pan, Zhao, Duan (CR213) 2019; 11
Kalluri, Weinberg (CR81) 2009; 119
Rinn, Kertesz, Wang, Squazzo, Xu, Brugmann (CR151) 2007; 129
Pineault, Wellik (CR142) 2014; 12
Shin, Lim, Reddy, Malakhova, Liu, Wang (CR166) 2017; 25
Hayashida, Takahashi, Chiba, Brachtel, Takahashi, Godin-Heymann (CR61) 2010; 107
Tan, Chen, Wu, Zhou, Zhu, Wu (CR182) 2018; 8
Moon, Kim, Yoon, Ahn (CR127) 2012; 287
Abbaszadegan, Moghbeli (CR2) 2018; 24
Nunes, Diniz, Moreira-Barbosa, Constâncio, Silva, Oliveira (CR131) 2019; 8
Tanzer, Amemiya, Kim, Stadler (CR183) 2005; 304
Ordóñez-Morán, Dafflon, Imajo, Nishida, Huelsken (CR133) 2015; 28
Matsunami, Sumiyama, Saitou (CR119) 2010; 71
Xu, Valerio, Eisold, Sinha, Koche, Hu (CR204) 2016; 30
Takeda, Goolsby, Yaseen (CR180) 2006; 66
Li, Dong, Cui, Wang, Hong (CR95) 2018; 37
Feng, Huang, Chen, Qiao, Liu, Ji (CR41) 2021; 11
Derakhshani, Rostami, Taefehshokr, Safarpour, Vaezi (CR35) 2020; 26
Fu, Chen, Zhou, Wang, Zhao, Zhao (CR43) 2017; 410
Li, Zhang, Wu, Gao, Yu, Wang (CR96) 2018; 285
Yan, Wu, Xiao, Hu, Fan, Zhu (CR209) 2018; 214
Kocak, Ackermann, Hero, Kahlert, Oberthuer, Juraeva (CR87) 2013; 4
Xia, Shan, Wang, Zhong, Geng, He (CR200) 2017; 8
Zagozewski, Zhang, Pinto, Wigle, Eisenstat (CR221) 2014; 393
Santini, Boore, Meyer (CR154) 2003; 13
Adamaki, Lambrou, Athanasiadou, Vlahopoulos, Papavassiliou, Moschovi (CR3) 2015; 39
Alvarado-Ruiz, Martinez-Silva, Torres-Reyes, Pina-Sanchez, Ortiz-Lazareno, Bravo-Cuellar (CR5) 2016; 17
Dang, Chen, Feng, Qiao, Han, Nie (CR32) 2020; 10
Carè, Felicetti, Meccia, Bottero, Parenza, Stoppacciaro (CR16) 2001; 61
Se, Kim, Kim, Kim, Dho, Kim (CR157) 2017; 49
Gaunt (CR48) 2018; 62
Ferrier, Holland (CR42) 2001; 2
Romero-Garcia, Prado-Garcia, Carlos-Reyes (CR152) 2020; 10
Mansoori, Mohammadi, Davudian, Shirjang, Baradaran (CR116) 2017; 7
Yang, Zhao, Wang, Ou-Yang, Hu, Li (CR212) 2019; 18
Liu, Tian, Zhao, Jia (CR112) 2019; 25
Sun, Han, Wang, Jin, Sun, Qu (CR176) 2017; 2017
Apiou, Flagiello, Cillo, Malfoy, Poupon, Dutrillaux (CR7) 1996; 73
Peng, Li, Li, Wu, Fan, Huang (CR141) 2020; 12
Pathiraja, Nayak, Xi, Jiang, Garee, Edwards (CR139) 2014; 6
Zhang, Nie, Sun, Xia, Xie, Lu (CR222) 2015; 36
Chen, Chung, Sukumar (CR19) 2004; 24
Hong, Jeong, Piao, Guo, Jung, Choi (CR66) 2015; 472
Singh, Gupta, Badarukhiya, Sachan (CR168) 2020; 147
Yang, Lee, Hur, Oh, Kim (CR211) 2018; 51
Guo, Zhang, Dou (CR54) 2019; 854
Li, Bai, Feng, Li, Yang, Guo (CR100) 2019; 9
Lee, Kim, Jeong, Kim (CR90) 2018; 503
Chen, Yang, Zhou, Yang, Feng, Wang (CR21) 2019; 689
Han, Li, Liang, Zhou (CR58) 2019; 8
Hu, Chen, Cheng, Li, Zhang (CR68) 2017; 129
Moens, Selleri (CR123) 2006; 291
Chang, Chan, Chen, Lee, Lin, Win (CR18) 2017; 8
Jan, Chaudhry (CR76) 2019; 9
Huo, Zhang, Yuan, Zhao, You (CR73) 2019; 23
Lescroart, Zaffran (CR92) 2018; 62
Abbasi (CR1) 2015; 225
Guan, He, Lv, Hou, Li, Song (CR51) 2019; 27
Mansour, Senga (CR117) 2017; 88
Park, Choi, Bae, Choi, Kim (CR138) 2017; 9
Wei, Zou, Becker, Anderson, Sumpter, Xiao (CR197) 2013; 154
de Bock, Demeyer, Degryse, Verbeke, Sweron, Gielen (CR34) 2018; 8
Wang, Jia, Chen, Yi, Wang, Li (CR189) 2016; 49
Gan, He, Zhang, Wei, Hu, Chen (CR44) 2018; 53
Zhang, Zhang, Cao, Huang, Cheng, Pang (CR225) 2018; 46
Hwang, Bin, Kim, Hong, Kim, Han (CR74) 2015; 54
Jung, Kim, Zhang, Lee, Sheng, Loehrer (CR79) 2005; 92
Sau, Lau, Cabrita, Nolan, Crooks, Visvader (CR156) 2016; 19
Sipeky, Gao, Zhang, Wang, Ettala, Talala (CR169) 2018; 24
Xue, Zhu, Chen, Wang (CR208) 2017; 9
Yang, Zhou, Mi, Ma, Fan, N
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M Matsunami (9657_CR119) 2010; 71
S Cheng (9657_CR22) 2018; 9
B Mansoori (9657_CR116) 2017; 7
J Gao (9657_CR46) 2013; 6
SP Nunes (9657_CR131) 2019; 8
H Liu (9657_CR110) 2018; 7
DE Ferrier (9657_CR42) 2001; 2
A Derakhshani (9657_CR35) 2020; 26
A Tanzer (9657_CR183) 2005; 304
C Li (9657_CR102) 2020; 19
X Peng (9657_CR140) 2018; 40
H Yang (9657_CR210) 2015; 34
G Cildir (9657_CR25) 2016; 22
T-F Yan (9657_CR209) 2018; 214
MA Mansour (9657_CR117) 2017; 88
J Yao (9657_CR215) 2019; 9
L Zhang (9657_CR226) 2019; 51
S-Y Li (9657_CR101) 2019; 120
H Sadik (9657_CR153) 2016; 76
J Guo (9657_CR54) 2019; 854
Y Guan (9657_CR51) 2019; 27
JL Beebe-Dimmer (9657_CR9) 2015; 24
J-P Sun (9657_CR177) 2018; 8
S-M Moon (9657_CR127) 2012; 287
N Nishida (9657_CR130) 2006; 2
Y Zhang (9657_CR225) 2018; 46
Q Li (9657_CR95) 2018; 37
M Hu (9657_CR69) 2019; 65
M Mallo (9657_CR115) 2018; 34
Y Cui (9657_CR29) 2020; 146
F Apiou (9657_CR7) 1996; 73
M Tsuboi (9657_CR185) 2017; 292
H Liu (9657_CR112) 2019; 25
SJ Thomas (9657_CR184) 2015; 113
Y-H Yuan (9657_CR220) 2019; 17
D Haria (9657_CR60) 2013; 1
H Chen (9657_CR20) 2016; 31
TN Pathiraja (9657_CR139) 2014; 6
S Santini (9657_CR154) 2003; 13
J Zhang (9657_CR227) 2020; 224
S Han (9657_CR58) 2019; 8
AA Abbasi (9657_CR1) 2015; 225
M-H Yang (9657_CR212) 2019; 18
Y Wang (9657_CR192) 2019; 33
V Raman (9657_CR149) 2000; 405
C Shaoqiang (9657_CR163) 2013; 30
J Wardwell-Ozgo (9657_CR194) 2014; 33
L Hou (9657_CR67) 2012; 41
Y-R Kim (9657_CR82) 2014; 33
SC Quinonez (9657_CR148) 2014; 111
S-L Chang (9657_CR18) 2017; 8
X-Y Huo (9657_CR73) 2019; 23
K Lee (9657_CR91) 2020; 46
K Jin (9657_CR77) 2012; 109
YJ Miyazaki (9657_CR122) 2002; 21
J Li (9657_CR103) 2020; 10
A Paço (9657_CR134) 2020; 13
C Yuan (9657_CR218) 2016; 35
Y Peng (9657_CR141) 2020; 12
M Zhang (9657_CR222) 2015; 36
MR Abbaszadegan (9657_CR2) 2018; 24
Y Guo (9657_CR53) 2017; 9
P Storti (9657_CR173) 2011; 25
J-Y Lee (9657_CR89) 2015; 11
W Li (9657_CR97) 2019; 17
Z Fu (9657_CR43) 2017; 410
L Marra (9657_CR118) 2013; 20
Y Zhong (9657_CR230) 2019; 218
T Zhou (9657_CR232) 2020; 11
P Yang (9657_CR213) 2019; 11
T-T Pan (9657_CR136) 2014; 234
R Kalluri (9657_CR81) 2009; 119
C Montagut (9657_CR126) 2012; 18
X Liu (9657_CR107) 2012; 12
SPH Chiang (9657_CR23) 2016; 311
SY Ko (9657_CR86) 2012; 122
BJ Shields (9657_CR165) 2019; 33
JY Song (9657_CR172) 2020; 117
B-L Gan (9657_CR44) 2018; 53
B Li (9657_CR99) 2019; 11
BM Costa (9657_CR27) 2010; 70
S-M Park (9657_CR138) 2017; 9
C-S Hong (9657_CR66) 2015; 472
J Xu (9657_CR203) 2009; 19
Y Dang (9657_CR32) 2020; 10
J Su (9657_CR174) 2018; 19
W Wasenang (9657_CR195) 2019; 11
Y-J Guo (9657_CR56) 2020; 19
H Kocak (9657_CR87) 2013; 4
D Gao (9657_CR45) 2018; 315
M Kmita (9657_CR85) 2003; 301
S Romero-Garcia (9657_CR152) 2020; 10
I Panagopoulos (9657_CR137) 2003; 36
Z Tan (9657_CR182) 2018; 8
B Zhang (9657_CR224) 2018; 26
I Nakayama (9657_CR129) 2013; 43
K Ohuchida (9657_CR132) 2012; 19
M Pojo (9657_CR143) 2015; 6
L Quagliata (9657_CR146) 2014; 59
C Guo (9657_CR52) 2017; 29
P Zhao (9657_CR228) 2015; 16
FU Weiss (9657_CR199) 2009; 137
L Zhuang (9657_CR233) 2015; 29
S Liu (9657_CR108) 2015; 75
H Xu (9657_CR205) 2018; 10
JC-G Hombría (9657_CR65) 2003; 71
L Alvarado-Ruiz (9657_CR5) 2016; 17
R Jan (9657_CR76) 2019; 9
B Xia (9657_CR200) 2017; 8
E Cerami (9657_CR17) 2012; 2
X-F Zhao (9657_CR229) 2020; 25
R Rezsohazy (9657_CR150) 2015; 142
S Bhatlekar (9657_CR11) 2018; 2018
M Adamaki (9657_CR3) 2015; 39
A Dongre (9657_CR36) 2019; 20
C Guo (9657_CR55) 2020; 20
JL Rinn (9657_CR151) 2007; 129
CB Moens (9657_CR123) 2006; 291
S Yao (9657_CR214) 2018; 501
R Zhang (9657_CR223) 2017; 10
X-P Cui (9657_CR28) 2014; 59
AB Weiner (9657_CR198) 2020; 12
CA Shah (9657_CR161) 2011; 286
F Xuan (9657_CR207) 2016; 18
H Hu (9657_CR68) 2017; 129
A Takeda (9657_CR180) 2006; 66
TV van Scherpenzeel (9657_CR186) 2005; 25
H Wang (9657_CR189) 2016; 49
A Carè (9657_CR16) 2001; 61
M Cantile (9657_CR15) 2012; 10
J Smith (9657_CR171) 2020; 6
MR Akbari (9657_CR4) 2013; 37
R Sever (9657_CR158) 2015; 5
S Sigismund (9657_CR167) 2018; 12
CE de Bock (9657_CR34) 2018; 8
Y Han (9657_CR57) 2018; 57
KM Pineault (9657_CR142) 2014; 12
Y Huang (9657_CR72) 2018; 15
References_xml – volume: 12
  start-page: 348
  year: 2012
  ident: CR107
  article-title: MicroRNA-196a promotes non-small cell lung cancer cell proliferation and invasion through targeting HOXA5
  publication-title: BMC Cancer
– volume: 18
  start-page: 31
  issue: 1
  year: 2019
  ident: CR212
  article-title: Nuclear lncRNA HOXD-AS1 suppresses colorectal carcinoma growth and metastasis via inhibiting HOXD3-induced integrin β3 transcriptional activating and MAPK/AKT signalling
  publication-title: Mol Cancer
– volume: 12
  start-page: 3
  issue: 1
  year: 2018
  end-page: 20
  ident: CR167
  article-title: Emerging functions of the EGFR in cancer
  publication-title: Mol Oncol
– volume: 19
  start-page: 1997
  issue: 3
  year: 2020
  end-page: 2007
  ident: CR56
  article-title: ERK/MAPK signalling pathway and tumorigenesis
  publication-title: Exp Ther Med
– volume: 25
  start-page: 711
  year: 2019
  end-page: 720
  ident: CR98
  article-title: Knock-down of HOXB8 prohibits proliferation and migration of colorectal cancer cells via Wnt/β-catenin signaling pathway
  publication-title: Med Sci Monit Int Med J Exp Clin Res
– volume: 39
  start-page: 1004
  issue: 5
  year: 2020
  end-page: 17
  ident: CR216
  article-title: Oncogenic HOXB8 is driven by MYC-regulated super-enhancer and potentiates colorectal cancer invasiveness via BACH1
  publication-title: Oncogene
– volume: 12
  start-page: 6861
  issue: 5
  year: 2015
  end-page: 6866
  ident: CR94
  article-title: Knockdown of homeobox A5 by small hairpin RNA inhibits proliferation and enhances cytarabine chemosensitivity of acute myeloid leukemia cells
  publication-title: Mol Med Rep
– volume: 218
  start-page: 1
  year: 2019
  end-page: 7
  ident: CR230
  article-title: Inhibition of HOXB7 suppresses p27-mediated acute lymphoblastic leukemia by regulating basic fibroblast growth factor and ERK1/2
  publication-title: Life Sci Netherlands
– volume: 51
  start-page: 157
  issue: 1
  year: 2019
  end-page: 65
  ident: CR226
  article-title: HOXB9 inhibits proliferation in gastric carcinoma cells via suppression of phosphorylated-Akt and NF-κB-dependent Snail expression
  publication-title: Dig. liver Dis
– volume: 62
  start-page: 6240
  issue: 21
  year: 2002
  end-page: 6245
  ident: CR75
  article-title: Impact of DNA amplification on gene expression patterns in breast cancer
  publication-title: Cancer Res
– volume: 154
  start-page: 1269
  issue: 6
  year: 2013
  end-page: 1284
  ident: CR197
  article-title: EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance
  publication-title: Cell
– volume: 34
  start-page: 1681
  issue: 4
  year: 2015
  end-page: 1691
  ident: CR210
  article-title: HOXD10 acts as a tumor-suppressive factor via inhibition of the RHOC/AKT/MAPK pathway in human cholangiocellular carcinoma
  publication-title: Oncol Rep
– volume: 10
  start-page: e0124191
  issue: 4
  year: 2015
  ident: CR187
  article-title: HOXA5 inhibits metastasis via regulating cytoskeletal remodelling and associates with prolonged survival in non-small-cell lung carcinoma
  publication-title: PLoS One
– volume: 25
  start-page: 22
  year: 2017
  end-page: 31
  ident: CR166
  article-title: A small molecule inhibitor of the β-catenin-TCF4 interaction suppresses colorectal cancer growth in vitro and in vivo
  publication-title: EBioMedicine
– volume: 5
  start-page: 619
  issue: 5
  year: 1995
  end-page: 627
  ident: CR12
  article-title: Homeobox genes in vertebrate gastrulation
  publication-title: Curr Opin. Genet. Dev
– volume: 2017
  start-page: 3680305
  year: 2017
  ident: CR176
  article-title: HOXB9 expression correlates with histological grade and prognosis in LSCC
  publication-title: Biomed Res Int
– volume: 30
  start-page: 863
  issue: 6
  year: 2016
  end-page: 878
  ident: CR204
  article-title: NUP98 fusion proteins interact with the NSL and MLL1 complexes to drive leukemogenesis
  publication-title: Cancer Cell
– volume: 366
  start-page: 141
  issue: 2
  year: 2012
  end-page: 149
  ident: CR38
  article-title: Germline mutations in HOXB13 and prostate-cancer risk
  publication-title: N Engl J Med
– volume: 9
  start-page: 836
  issue: 7
  year: 2018
  end-page: 846
  ident: CR164
  article-title: Downregulation of HOXA13 sensitizes human esophageal squamous cell carcinoma to chemotherapy
  publication-title: Thorac Cancer
– volume: 33
  start-page: 1868
  issue: 8
  year: 2019
  end-page: 1880
  ident: CR165
  article-title: The NUP98-HOXD13 fusion oncogene induces thymocyte self-renewal via Lmo2/Lyl1
  publication-title: Leukemia
– volume: 73
  start-page: 5449
  issue: 17
  year: 2013
  end-page: 5458
  ident: CR162
  article-title: HOXB13 mediates tamoxifen resistance and invasiveness in human breast cancer by suppressing ERα and inducing IL-6 expression
  publication-title: Cancer Res
– volume: 47
  start-page: 1058
  issue: 6
  year: 2020
  end-page: 1066
  ident: CR175
  article-title: Homeobox B5 suppression attenuates proliferation and elevates apoptosis in hepatoma cell lines through ERK/MDM2 signalling
  publication-title: Clin Exp Pharmacol Physiol
– volume: 21
  start-page: 798
  issue: 5
  year: 2002
  end-page: 808
  ident: CR122
  article-title: HOXD3 enhances motility and invasiveness through the TGF-beta-dependent and -independent pathways in A549 cells
  publication-title: Oncogene
– volume: 41
  start-page: 1122
  issue: 2
  year: 2019
  end-page: 30
  ident: CR193
  article-title: HOXA5 inhibits the proliferation and induces the apoptosis of cervical cancer cells via regulation of protein kinase B and p27
  publication-title: Oncol Rep
– volume: 59
  start-page: 911
  issue: 3
  year: 2014
  end-page: 923
  ident: CR146
  article-title: Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients
  publication-title: Hepatology
– volume: 33
  start-page: 1017
  issue: 8
  year: 2014
  end-page: 1026
  ident: CR194
  article-title: HOXA1 drives melanoma tumor growth and metastasis and elicits an invasion gene expression signature that prognosticates clinical outcome
  publication-title: Oncogene
– volume: 17
  start-page: 9
  issue: 1
  year: 2019
  ident: CR220
  article-title: Epigenetic inactivation of HOXD10 is associated with human colon cancer via inhibiting the RHOC/AKT/MAPK signaling pathway
  publication-title: Cell Commun Signal
– volume: 11
  start-page: 420
  issue: 6
  year: 2020
  ident: CR113
  article-title: HOXA5 inhibits the proliferation and neoplasia of cervical cancer cells via downregulating the activity of the Wnt/β-catenin pathway and transactivating TP53
  publication-title: Cell Death Dis
– volume: 49
  start-page: 387
  issue: 2
  year: 2017
  end-page: 398
  ident: CR157
  article-title: Underexpression of HOXA11 is associated with treatment resistance and poor prognosis in glioblastoma
  publication-title: Cancer Res Treat
– volume: 147
  start-page: 1740
  issue: 6
  year: 2020
  end-page: 1752
  ident: CR168
  article-title: Detection of aberrant methylation of HOXA9 and HIC1 through multiplex MethyLight assay in serum DNA for the early detection of epithelial ovarian cancer
  publication-title: Int J Cancer
– volume: 64
  start-page: 3046
  issue: 9
  year: 2004
  end-page: 3051
  ident: CR78
  article-title: HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4
  publication-title: Cancer Res
– volume: 25
  start-page: 7492
  issue: 57
  year: 2006
  end-page: 7504
  ident: CR8
  article-title: Diversity of LEF/TCF action in development and disease
  publication-title: Oncogene England
– volume: 10
  start-page: 368
  year: 2020
  ident: CR103
  article-title: Expression profile and prognostic values of HOXA family members in laryngeal squamous cell cancer
  publication-title: Front Oncol
– volume: 25
  start-page: 384
  issue: 4
  year: 2005
  end-page: 395
  ident: CR186
  article-title: Mutation analysis of the HOX paralogous 4–13 genes in children with acute lymphoid malignancies: identification of a novel germline mutation of HOXD4 leading to a partial loss-of-function
  publication-title: Hum Mutat
– volume: 9
  start-page: 465
  issue: 5
  year: 2018
  ident: CR22
  article-title: HOXA4, down-regulated in lung cancer, inhibits the growth, motility and invasion of lung cancer cells
  publication-title: Cell Death Dis
– volume: 12
  start-page: 1803
  year: 2019
  end-page: 1813
  ident: CR144
  article-title: Elevated HOXA13 expression promotes the proliferation and metastasis of gastric cancer partly via activating Erk1/2
  publication-title: Onco Targets Ther
– volume: 15
  start-page: 2756
  issue: 3
  year: 2018
  end-page: 2762
  ident: CR196
  article-title: Upregulated HOXA9 expression is associated with lymph node metastasis in colorectal cancer
  publication-title: Oncol Lett
– volume: 11
  start-page: 701
  issue: 6
  year: 2015
  end-page: 711
  ident: CR89
  article-title: HOXB5 promotes the proliferation and invasion of breast cancer cells
  publication-title: Int J Biol Sci
– volume: 11
  start-page: 2612
  issue: 6
  year: 2021
  end-page: 2633
  ident: CR41
  article-title: CXCL12-mediated HOXB5 overexpression facilitates colorectal cancer metastasis through transactivating CXCR4 and ITGB3
  publication-title: Theranostics
– volume: 11
  start-page: 2063
  year: 2018
  end-page: 2073
  ident: CR201
  article-title: Role of the NFκB-signaling pathway in cancer
  publication-title: Onco Targets Ther
– volume: 26
  start-page: 1
  issue: 8
  year: 2020
  end-page: 24
  ident: CR35
  article-title: An overview of the oncogenic signaling pathways in different types of cancers
  publication-title: Cancer
– volume: 36
  start-page: 3521
  issue: 5
  year: 2015
  end-page: 31
  ident: CR222
  article-title: HOXA5 indicates poor prognosis and suppresses cell proliferation by regulating p21 expression in non small cell lung cancer
  publication-title: Tumour Biol
– volume: 13
  start-page: 1111
  issue: 6A
  year: 2003
  end-page: 1122
  ident: CR154
  article-title: Evolutionary conservation of regulatory elements in vertebrate Hox gene clusters
  publication-title: Genome Res
– volume: 9
  start-page: 116
  year: 2017
  ident: CR53
  article-title: Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma
  publication-title: Clin Epigenetics
– volume: 286
  start-page: 3161
  issue: 4
  year: 2011
  end-page: 3176
  ident: CR161
  article-title: HoxA10 regulates transcription of the gene encoding transforming growth factor beta2 (TGFbeta2) in myeloid cells
  publication-title: J Biol Chem
– volume: 66
  start-page: 6628
  issue: 13
  year: 2006
  end-page: 6637
  ident: CR180
  article-title: NUP98-HOXA9 induces long-term proliferation and blocks differentiation of primary human CD34+ hematopoietic cells
  publication-title: Cancer Res
– volume: 8
  start-page: 5143
  issue: 18
  year: 2018
  end-page: 5158
  ident: CR182
  article-title: Overexpression of HOXC10 promotes angiogenesis in human glioma via interaction with PRMT5 and upregulation of VEGFA expression
  publication-title: Theranostics
– volume: 292
  start-page: 17681
  issue: 43
  year: 2017
  end-page: 17702
  ident: CR185
  article-title: The transcription factor HOXB7 regulates ERK kinase activity and thereby stimulates the motility and invasiveness of pancreatic cancer cells
  publication-title: J Biol Chem
– volume: 98
  start-page: 95
  issue: 1
  year: 2018
  end-page: 105
  ident: CR147
  article-title: High expression of HOXA13 correlates with poorly differentiated hepatocellular carcinomas and modulates sorafenib response in in vitro models
  publication-title: Lab Invest
– volume: 16
  start-page: 85
  year: 2016
  ident: CR128
  article-title: HOX transcription factors are potential targets and markers in malignant mesothelioma
  publication-title: BMC Cancer
– volume: 501
  start-page: 628
  issue: 3
  year: 2018
  end-page: 35
  ident: CR214
  article-title: HOXC10 promotes gastric cancer cell invasion and migration via regulation of the NF-κB pathway
  publication-title: Biochem Biophys Res Commun
– volume: 33
  start-page: 4558
  issue: 37
  year: 2014
  end-page: 4567
  ident: CR82
  article-title: HOXB13 downregulates intracellular zinc and increases NF-κB signaling to promote prostate cancer metastasis
  publication-title: Oncogene
– volume: 109
  start-page: 2736
  issue: 8
  year: 2012
  end-page: 2741
  ident: CR77
  article-title: The HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathway
  publication-title: Proc Natl Acad Sci U S A
– volume: 410
  start-page: 68
  year: 2017
  end-page: 81
  ident: CR43
  article-title: LncRNA HOTTIP modulates cancer stem cell properties in human pancreatic cancer by regulating HOXA9
  publication-title: Cancer Lett Ireland
– volume: 29
  start-page: 572
  issue: 6
  year: 2017
  end-page: 580
  ident: CR52
  article-title: HOXC10 up-regulation promotes gastric cancer cell proliferation and metastasis through MAPK pathway
  publication-title: Chin J Cancer Res
– volume: 108
  start-page: 4914
  issue: 12
  year: 2011
  end-page: 4919
  ident: CR6
  article-title: T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis
  publication-title: Proc Natl Acad Sci U S A
– volume: 88
  start-page: 1
  year: 2017
  end-page: 13
  ident: CR117
  article-title: HOXD8 exerts a tumor-suppressing role in colorectal cancer as an apoptotic inducer
  publication-title: Int J Biochem Cell Biol Netherlands
– volume: 113
  start-page: 365
  issue: 3
  year: 2015
  end-page: 371
  ident: CR184
  article-title: The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours
  publication-title: Br J Cancer
– volume: 2
  start-page: 33
  issue: 1
  year: 2001
  end-page: 38
  ident: CR42
  article-title: Ancient origin of the Hox gene cluster
  publication-title: Nat Rev Genet
– volume: 8
  start-page: 1247
  issue: 1
  year: 2017
  end-page: 1261
  ident: CR62
  article-title: HOXB7 overexpression promotes cell proliferation and correlates with poor prognosis in gastric cancer patients by inducing expression of both AKT and MARKs
  publication-title: Oncotarget
– volume: 62
  start-page: 673
  issue: 11–12
  year: 2018
  end-page: 683
  ident: CR48
  article-title: Hox cluster genes and collinearities throughout the tree of animal life
  publication-title: Int J Dev Biol
– volume: 122
  start-page: 3603
  issue: 10
  year: 2012
  end-page: 3617
  ident: CR86
  article-title: HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts
  publication-title: J Clin Invest
– volume: 214
  start-page: 1818
  issue: 11
  year: 2018
  end-page: 24
  ident: CR209
  article-title: Knockdown of HOXC6 inhibits glioma cell proliferation and induces cell cycle arrest by targeting WIF-1 in vitro and vivo
  publication-title: Pathol Res Pract
– volume: 22
  start-page: 414
  issue: 5
  year: 2016
  end-page: 429
  ident: CR25
  article-title: Noncanonical NF-κB signaling in health and disease
  publication-title: Trends Mol Med
– volume: 9
  start-page: 73
  year: 2017
  ident: CR138
  article-title: A long-range interactive DNA methylation marker panel for the promoters of HOXA9 and HOXA10 predicts survival in breast cancer patients
  publication-title: Clin Epigenetics
– volume: 37
  start-page: 15087
  issue: 11
  year: 2016
  end-page: 15096
  ident: CR33
  article-title: HOX genes: potential candidates for the progression of laryngeal squamous cell carcinoma
  publication-title: Tumour Biol J Int Soc Oncodev Biol Med Netherlands
– volume: 26
  start-page: 3998
  issue: 27
  year: 2007
  end-page: 4008
  ident: CR124
  article-title: HOXA1-stimulated oncogenicity is mediated by selective upregulation of components of the p44/42 MAP kinase pathway in human mammary carcinoma cells
  publication-title: Oncogene
– volume: 62
  start-page: 837
  issue: 11–12
  year: 2018
  end-page: 846
  ident: CR92
  article-title: Hox and Tale transcription factors in heart development and disease
  publication-title: Int J Dev Biol
– volume: 146
  start-page: 1993
  issue: 8
  year: 2020
  end-page: 2006
  ident: CR29
  article-title: Comprehensive analysis of the HOXA gene family identifies HOXA13 as a novel oncogenic gene in kidney renal clear cell carcinoma
  publication-title: J Cancer Res Clin Oncol.
– volume: 53
  start-page: 1557
  issue: 4
  year: 2018
  end-page: 1579
  ident: CR44
  article-title: Downregulation of HOXA3 in lung adenocarcinoma and its relevant molecular mechanism analysed by RT-qPCR, TCGA and in silico analysis
  publication-title: Int J Oncol
– volume: 144
  start-page: 646
  issue: 5
  year: 2011
  end-page: 674
  ident: CR59
  article-title: Hallmarks of cancer: the next generation
  publication-title: Cell
– volume: 234
  start-page: 395
  issue: 1
  year: 2018
  end-page: 413
  ident: CR13
  article-title: Noncoding RNAs within the HOX gene network in tumor pathogenesis and progression
  publication-title: J Cell Physiol
– volume: 20
  start-page: 127
  issue: 1
  year: 2019
  ident: CR63
  article-title: miR-10b suppresses cell invasion and metastasis through targeting HOXA3 regulated by FAK/YAP signaling pathway in clear-cell renal cell carcinoma
  publication-title: BMC Nephrol
– volume: 129
  start-page: 1311
  issue: 7
  year: 2007
  end-page: 1323
  ident: CR151
  article-title: Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs
  publication-title: Cell
– volume: 28
  start-page: 815
  issue: 6
  year: 2015
  end-page: 829
  ident: CR133
  article-title: HOXA5 counteracts stem cell traits by inhibiting Wnt signaling in colorectal cancer
  publication-title: Cancer Cell
– volume: 46
  start-page: 1737
  issue: 4
  year: 2018
  end-page: 47
  ident: CR225
  article-title: HOXD3 plays a critical role in breast cancer stemness and drug resistance
  publication-title: Cell. Physiol. Biochem
– volume: 6
  start-page: 1
  issue: 269
  year: 2013
  ident: CR46
  article-title: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
  publication-title: Sci Signal.
– volume: 75
  start-page: 709
  issue: 4
  year: 2015
  end-page: 719
  ident: CR108
  article-title: HOXB7 promotes malignant progression by activating the TGFβ signaling pathway
  publication-title: Cancer Res
– volume: 12
  start-page: 19375
  issue: 19
  year: 2020
  end-page: 19398
  ident: CR141
  article-title: HOXC10 promotes tumour metastasis by regulating the EMT-related gene Slug in ovarian cancer
  publication-title: Aging
– volume: 77
  start-page: 3181
  issue: 12
  year: 2017
  end-page: 3193
  ident: CR114
  article-title: TWIST1-WDR5-Hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis
  publication-title: Cancer Res
– volume: 8
  start-page: 1500
  issue: 9
  year: 2019
  ident: CR131
  article-title: Subtyping lung cancer using DNA methylation in liquid biopsies
  publication-title: J Clin Med
– volume: 25
  start-page: 2044
  issue: 12
  year: 2020
  end-page: 54
  ident: CR229
  article-title: HOXC9 overexpression is associated with gastric cancer progression and a prognostic marker for poor survival in gastric cancer patients
  publication-title: Int J Clin Oncol
– volume: 24
  start-page: 6265
  issue: 24
  year: 2018
  end-page: 6276
  ident: CR169
  article-title: Synergistic interaction of HOXB13 and CIP2A predisposes to aggressive prostate cancer
  publication-title: Clin Cancer Res
– volume: 10
  start-page: 1703
  issue: 6
  year: 2018
  end-page: 1712
  ident: CR205
  article-title: HOXB5 promotes retinoblastoma cell migration and invasion via ERK1/2 pathway-mediated MMPs production
  publication-title: Am J Transl Res
– volume: 46
  start-page: 1066
  issue: 6
  year: 2020
  end-page: 1073
  ident: CR91
  article-title: HOXB5 acts as an oncogenic driver in head and neck squamous cell carcinoma via EGFR/Akt/Wnt/β-catenin signaling axis
  publication-title: Eur. J. Surg. Oncol. J. Eur. Soc.
– volume: 92
  start-page: 2233
  issue: 12
  year: 2005
  end-page: 2239
  ident: CR79
  article-title: HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation
  publication-title: Br J Cancer
– volume: 61
  start-page: 6532
  issue: 17
  year: 2001
  end-page: 6539
  ident: CR16
  article-title: HOXB7: a key factor for tumor-associated angiogenic switch
  publication-title: Cancer Res
– volume: 37
  start-page: 265
  issue: 1
  year: 2018
  ident: CR95
  article-title: Over-expressed lncRNA HOTAIRM1 promotes tumor growth and invasion through up-regulating HOXA1 and sequestering G9a/EZH2/Dnmts away from the HOXA1 gene in glioblastoma multiforme
  publication-title: J Exp Clin Cancer Res
– volume: 10
  start-page: 361
  issue: 5
  year: 2010
  end-page: 371
  ident: CR160
  article-title: The Hox genes and their roles in oncogenesis
  publication-title: Nat Rev Cancer
– volume: 2
  start-page: 401
  issue: 5
  year: 2012
  end-page: 404
  ident: CR17
  article-title: The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data
  publication-title: Cancer Discov
– volume: 8
  start-page: 1647
  issue: 9
  year: 2017
  end-page: 1654
  ident: CR18
  article-title: HOXC6 overexpression is associated with Ki-67 expression and poor survival in NPC patients
  publication-title: J Cancer
– volume: 24
  start-page: 1366
  issue: 9
  year: 2015
  end-page: 1372
  ident: CR9
  article-title: The HOXB13 G84E mutation is associated with an increased risk for prostate cancer and other malignancies
  publication-title: Cancer Epidemiol Biomarkers Prev
– volume: 59
  start-page: 1442
  issue: 7
  year: 2014
  end-page: 1451
  ident: CR28
  article-title: HOXA10 promotes cell invasion and MMP-3 expression via TGFβ2-mediated activation of the p38 MAPK pathway in pancreatic cancer cells
  publication-title: Dig Dis Sci
– volume: 225
  start-page: 353
  issue: 6
  year: 2015
  end-page: 357
  ident: CR1
  article-title: Diversification of four human HOX gene clusters by step-wise evolution rather than ancient whole-genome duplications
  publication-title: Dev Genes Evol Germany
– volume: 26
  start-page: 1535
  issue: 5
  year: 2019
  end-page: 1543
  ident: CR121
  article-title: Homeobox C10 influences on the malignant phenotype of gastric cancer cell lines and its elevated expression positively correlates with recurrence and poor survival
  publication-title: Ann Surg Oncol
– volume: 22
  start-page: 390
  issue: 6
  year: 2018
  end-page: 7
  ident: CR219
  article-title: Upregulation of HOXA10 protein expression predicts poor prognosis for colorectal cancer
  publication-title: Genet Test Mol Biomarkers
– volume: 11
  start-page: 3071
  issue: 11
  year: 2020
  end-page: 3085
  ident: CR232
  article-title: HOXB7 mediates cisplatin resistance in esophageal squamous cell carcinoma through involvement of DNA damage repair
  publication-title: Thorac Cancer
– volume: 129
  start-page: 391
  issue: 11–12
  year: 2017
  end-page: 397
  ident: CR68
  article-title: Dysregulated expression of homebox gene HOXA13 is correlated with the poor prognosis in bladder cancer
  publication-title: Wien Klin. Wochenschr
– volume: 12
  start-page: 420
  issue: 4
  year: 2014
  end-page: 427
  ident: CR142
  article-title: Hox genes and limb musculoskeletal development
  publication-title: Curr Osteoporos Rep
– volume: 11
  start-page: 528
  issue: 4
  year: 2019
  ident: CR99
  article-title: The role of HOX transcription factors in cancer predisposition and progression
  publication-title: Cancers (basel).
– volume: 71
  start-page: 427
  issue: 5–6
  year: 2010
  end-page: 436
  ident: CR119
  article-title: Evolution of conserved non-coding sequences within the vertebrate Hox clusters through the two-round whole genome duplications revealed by phylogenetic footprinting analysis
  publication-title: J Mol Evol
– volume: 37
  start-page: 424
  issue: 4
  year: 2013
  end-page: 427
  ident: CR4
  article-title: Germline HOXB13 p.Gly84Glu mutation and risk of colorectal cancer
  publication-title: Cancer Epidemiol
– volume: 21
  start-page: 1234
  issue: 6
  year: 2017
  end-page: 1241
  ident: CR145
  article-title: CDH17 is a downstream effector of HOXA13 in modulating the Wnt/β-catenin signaling pathway in gastric cancer
  publication-title: Eur Rev Med Pharmacol Sci
– volume: 15
  start-page: e0236811
  issue: 8
  year: 2020
  ident: CR80
  article-title: Increased HOXC6 mRNA expression is a novel biomarker of gastric cancer
  publication-title: PLoS ONE
– volume: 36
  start-page: 2821
  issue: 4
  year: 2015
  end-page: 2829
  ident: CR109
  article-title: Overexpression of HOXC11 homeobox gene in clear cell renal cell carcinoma induces cellular proliferation and is associated with poor prognosis
  publication-title: Tumour Biol J Int Soc Oncodevelopmental Biol Med
– volume: 18
  start-page: 819
  issue: 6
  year: 2016
  end-page: 829
  ident: CR207
  article-title: Homeobox C9 suppresses Beclin1-mediated autophagy in glioblastoma by directly inhibiting the transcription of death-associated protein kinase 1
  publication-title: Neuro Oncol
– volume: 33
  start-page: e22873
  issue: 5
  year: 2019
  ident: CR231
  article-title: The clinical significance of HOXA9 promoter hypermethylation in head and neck squamous cell carcinoma
  publication-title: J Clin Lab Anal
– volume: 6
  start-page: 27778
  issue: 29
  year: 2015
  end-page: 27793
  ident: CR37
  article-title: HOXA13 is a potential GBM diagnostic marker and promotes glioma invasion by activating the Wnt and TGF-β pathways
  publication-title: Oncotarget
– volume: 111
  start-page: 4
  issue: 1
  year: 2014
  end-page: 15
  ident: CR148
  article-title: Human HOX gene disorders
  publication-title: Mol Genet Metab
– volume: 25
  start-page: 527
  issue: 3
  year: 2011
  end-page: 537
  ident: CR173
  article-title: HOXB7 expression by myeloma cells regulates their pro-angiogenic properties in multiple myeloma patients
  publication-title: Leukemia
– volume: 11
  start-page: 3416
  issue: 12
  year: 2020
  end-page: 3423
  ident: CR84
  article-title: The LncRNA HOTAIRM1 promotes tamoxifen resistance by mediating HOXA1 expression in ER+ breast cancer cells
  publication-title: J Cancer
– volume: 65
  start-page: 190
  issue: 8
  year: 2019
  ident: CR69
  article-title: Clinical prognostic significance of HOXC9 expression in patients with colorectal cancer
  publication-title: Clin Lab.
– volume: 31
  start-page: 828
  issue: 8
  year: 2020
  end-page: 835
  ident: CR47
  article-title: HOXB5 promotes proliferation, migration, and invasion of pancreatic cancer cell through the activation of the GSK3β/β-catenin pathway
  publication-title: Anticancer Drugs
– volume: 20
  start-page: 69
  issue: 2
  year: 2019
  end-page: 84
  ident: CR36
  article-title: New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer
  publication-title: Nat Rev Mol Cell Biol
– volume: 234
  start-page: 209
  issue: 3
  year: 2014
  end-page: 219
  ident: CR136
  article-title: Overexpression of HOXA13 as a potential marker for diagnosis and poor prognosis of hepatocellular carcinoma
  publication-title: Tohoku J Exp Med
– volume: 8
  start-page: 47121
  issue: 29
  year: 2017
  end-page: 47135
  ident: CR190
  article-title: HOXB7 promotes tumor progression via bFGF-induced activation of MAPK/ERK pathway and indicated poor prognosis in hepatocellular carcinoma
  publication-title: Oncotarget
– volume: 118
  start-page: 6247
  issue: 24
  year: 2011
  end-page: 6257
  ident: CR50
  article-title: NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights
  publication-title: Blood
– volume: 41
  start-page: 2285
  issue: 6
  year: 2012
  end-page: 2295
  ident: CR67
  article-title: The prolactin receptor mediates HOXA1-stimulated oncogenicity in mammary carcinoma cells
  publication-title: Int J Oncol
– volume: 142
  start-page: 1212
  issue: 7
  year: 2015
  end-page: 1227
  ident: CR150
  article-title: Cellular and molecular insights into Hox protein action
  publication-title: Development
– volume: 8
  start-page: 41415
  year: 2018
  end-page: 41421
  ident: CR177
  article-title: Down-regulation of HOXB5 inhibits TGF-β-induced migration and invasion in hepatocellular carcinoma cells via inactivation of the PI3K/Akt pathway
  publication-title: RSC Adv
– volume: 2018
  start-page: 3569493
  year: 2018
  ident: CR11
  article-title: Role of HOX genes in stem cell differentiation and cancer
  publication-title: Stem Cells Int
– volume: 35
  start-page: 15
  year: 2016
  ident: CR218
  article-title: Elevated HOXA1 expression correlates with accelerated tumor cell proliferation and poor prognosis in gastric cancer partly via cyclin D1
  publication-title: J Exp Clin Cancer Res
– volume: 23
  start-page: 2476
  issue: 6
  year: 2019
  end-page: 2485
  ident: CR73
  article-title: HOXB7 promotes proliferation and metastasis of glioma by regulating the Wnt/β-catenin pathway
  publication-title: Eur Rev Med Pharmacol Sci
– volume: 30
  start-page: 155
  issue: 2
  year: 2013
  end-page: 163
  ident: CR163
  article-title: Expression of HOXD3 correlates with shorter survival in patients with invasive breast cancer
  publication-title: Clin Exp Metastasis
– volume: 8
  start-page: 13483
  issue: 1
  year: 2018
  ident: CR178
  article-title: Potential role of the HOXD8 transcription factor in cisplatin resistance and tumour metastasis in advanced epithelial ovarian cancer
  publication-title: Sci Rep
– volume: 71
  start-page: 461
  issue: 8
  year: 2003
  end-page: 476
  ident: CR65
  article-title: Beyond homeosis-HOX function in morphogenesis and organogenesis
  publication-title: Differentiation
– volume: 17
  start-page: 1037
  issue: 3
  year: 2016
  end-page: 1047
  ident: CR5
  article-title: HOXA9 is underexpressed in cervical cancer cells and its restoration decreases proliferation, migration and expression of epithelial-to-mesenchymal transition genes
  publication-title: Asian Pac. J. Cancer Prev. Thailand
– volume: 11
  start-page: 512
  issue: 4
  year: 2019
  ident: CR170
  article-title: A case of identity: HOX genes in normal and cancer stem cells
  publication-title: Cancers (basel).
– volume: 9
  start-page: 1151
  issue: 3
  year: 2017
  end-page: 1161
  ident: CR208
  article-title: HoxB9 promotes the migration and invasion via TGF-β1/Smad2/Slug signaling pathway in oral squamous cell carcinoma
  publication-title: Am J Transl Res
– volume: 75
  start-page: 23
  issue: 1
  year: 2006
  end-page: 31
  ident: CR88
  article-title: HOX genes: seductive science, mysterious mechanisms
  publication-title: Ulster Med J
– volume: 148
  start-page: 3060
  issue: 15
  year: 2021
  end-page: 3070
  ident: CR206
  article-title: HOXD13 suppresses prostate cancer metastasis and BMP4-induced epithelial-mesenchymal transition by inhibiting SMAD1
  publication-title: Int J cancer
– volume: 10
  start-page: 1152
  year: 2020
  ident: CR152
  article-title: Role of DNA methylation in the resistance to therapy in solid tumors
  publication-title: Front Oncol
– volume: 9
  start-page: 394
  year: 2019
  ident: CR100
  article-title: Study of promoter methylation patterns of HOXA2, HOXA5, and HOXA6 and its clinicopathological characteristics in colorectal cancer
  publication-title: Front Oncol
– volume: 393
  start-page: 195
  issue: 2
  year: 2014
  end-page: 208
  ident: CR221
  article-title: The role of homeobox genes in retinal development and disease
  publication-title: Dev Biol
– volume: 17
  start-page: 3569
  issue: 11
  year: 2011
  end-page: 3578
  ident: CR106
  article-title: HOXB7 as a prognostic factor and mediator of colorectal cancer progression
  publication-title: Clin Cancer Res
– volume: 117
  start-page: 1279
  issue: 6
  year: 2016
  end-page: 1287
  ident: CR179
  article-title: TGF-β Signaling in cancer
  publication-title: J Cell Biochem.
– volume: 2
  start-page: 213
  issue: 3
  year: 2006
  end-page: 219
  ident: CR130
  article-title: Angiogenesis in cancer
  publication-title: Vasc Health Risk Manag
– volume: 7
  start-page: 339
  issue: 3
  year: 2017
  end-page: 348
  ident: CR116
  article-title: The different mechanisms of cancer drug resistance: a brief review
  publication-title: Adv Pharm Bull
– volume: 149
  start-page: 2219
  issue: 5
  year: 2008
  end-page: 2229
  ident: CR125
  article-title: Transcriptional activation of signal transducer and activator of transcription (STAT) 3 and STAT5B partially mediate homeobox A1-stimulated oncogenic transformation of the immortalized human mammary epithelial cell
  publication-title: Endocrinology
– volume: 18
  start-page: 49
  issue: 1
  year: 2019
  end-page: 56
  ident: CR111
  article-title: Homeobox A10 promotes the proliferation and invasion of bladder cancer cells via regulation of matrix metalloproteinase-3
  publication-title: Oncol Lett
– volume: 2
  start-page: 31
  issue: 1
  year: 2013
  end-page: 45
  ident: CR64
  article-title: Evolution of homeobox genes
  publication-title: Wiley Interdiscip Rev Dev Biol
– volume: 15
  start-page: 7291
  issue: 5
  year: 2018
  end-page: 7296
  ident: CR72
  article-title: Upregulated expression of HOXC8 is associated with poor prognosis of cervical cancer
  publication-title: Oncol Lett
– volume: 36
  start-page: 86
  issue: 1
  year: 2017
  ident: CR70
  article-title: HOXB7 accelerates the malignant progression of hepatocellular carcinoma by promoting stemness and epithelial-mesenchymal transition
  publication-title: J Exp Clin Cancer Res
– volume: 11
  start-page: 8167
  year: 2019
  end-page: 8179
  ident: CR213
  article-title: Overexpression of HOXC6 promotes cell proliferation and migration via MAPK signaling and predicts a poor prognosis in glioblastoma
  publication-title: Cancer Manag Res
– volume: 6
  start-page: 10
  year: 2006
  ident: CR71
  article-title: Decreased intracellular zinc in human tumorigenic prostate epithelial cells: a possible role in prostate cancer progression
  publication-title: Cancer Cell Int
– volume: 19
  start-page: 899
  issue: 1
  year: 2020
  end-page: 907
  ident: CR102
  article-title: Bioinformatics analysis of the expression of HOXC13 and its role in the prognosis of breast cancer
  publication-title: Oncol Lett
– volume: 14
  start-page: 137
  issue: 2
  year: 2017
  end-page: 141
  ident: CR24
  article-title: Overexpression of microRNA-196b accelerates invasiveness of cancer cells in recurrent epithelial ovarian cancer through regulation of homeobox A9
  publication-title: Cancer Genomics Proteomics
– volume: 24
  start-page: 245
  issue: 2
  year: 2018
  end-page: 250
  ident: CR2
  article-title: Role of MAML1 and MEIS1 in esophageal squamous cell carcinoma depth of invasion
  publication-title: Pathol Oncol Res Switzerland
– volume: 137
  start-page: 2136
  issue: 6
  year: 2009
  end-page: 7
  ident: CR199
  article-title: Retinoic acid receptor antagonists inhibit miR-10a expression and block metastatic behavior of pancreatic cancer
  publication-title: Gastroenterology
– volume: 5
  start-page: 28
  issue: 1
  year: 2020
  ident: CR39
  article-title: Molecular principles of metastasis: a hallmark of cancer revisited
  publication-title: Signal Transduct Target Ther
– volume: 11
  start-page: 39
  issue: 1
  year: 2019
  ident: CR195
  article-title: Serum cell-free DNA methylation of OPCML and HOXD9 as a biomarker that may aid in differential diagnosis between cholangiocarcinoma and other biliary diseases
  publication-title: Clin Epigenetics
– volume: 8
  start-page: 616
  issue: 5
  year: 2018
  end-page: 631
  ident: CR34
  article-title: HOXA9 cooperates with activated JAK/STAT signaling to drive leukemia development
  publication-title: Cancer Discov
– volume: 9
  start-page: 205
  issue: 2
  year: 2019
  end-page: 218
  ident: CR76
  article-title: Understanding apoptosis and apoptotic pathways targeted cancer therapeutics
  publication-title: Adv. Pharm. Bull
– volume: 311
  start-page: C1
  issue: 1
  year: 2016
  end-page: 14
  ident: CR23
  article-title: Tumor cell intravasation
  publication-title: Am J Physiol Cell Physiol
– volume: 13
  start-page: 10
  issue: 1
  year: 2020
  ident: CR134
  article-title: Roles of the HOX proteins in cancer invasion and metastasis
  publication-title: Cancers
– volume: 6
  start-page: 392
  issue: 5
  year: 2020
  end-page: 406
  ident: CR171
  article-title: Promoter DNA hypermethylation and paradoxical gene activation
  publication-title: Trends in Cancer
– volume: 42
  start-page: 202
  issue: 1
  year: 2019
  end-page: 212
  ident: CR83
  article-title: HOXC10 overexpression promotes cell proliferation and migration in gastric cancer
  publication-title: Oncol Rep
– volume: 31
  start-page: 225
  issue: 6
  year: 2016
  end-page: 231
  ident: CR20
  article-title: miR-10b inhibits apoptosis and promotes proliferation and invasion of endometrial cancer cells via targeting HOXB3
  publication-title: Cancer Biother Radiopharm
– volume: 301
  start-page: 331
  issue: 5631
  year: 2003
  end-page: 333
  ident: CR85
  article-title: Organizing axes in time and space; 25 years of colinear tinkering
  publication-title: Science
– volume: 49
  start-page: 2529
  issue: 6
  year: 2016
  end-page: 37
  ident: CR189
  article-title: HOXB4 knockdown reverses multidrug resistance of human myelogenous leukemia K562/ADM cells by downregulating P-gp, MRP1 and BCRP expression via PI3K/Akt signaling pathway
  publication-title: Int. J. Oncol.
– volume: 119
  start-page: 1420
  issue: 6
  year: 2009
  end-page: 1428
  ident: CR81
  article-title: The basics of epithelial-mesenchymal transition
  publication-title: J Clin Invest
– volume: 19
  start-page: 2394
  issue: 7
  year: 2012
  end-page: 2402
  ident: CR132
  article-title: MicroRNA-10a is overexpressed in human pancreatic cancer and involved in its invasiveness partially via suppression of the HOXA1 gene
  publication-title: Ann Surg Oncol
– volume: 405
  start-page: 974
  issue: 6789
  year: 2000
  end-page: 978
  ident: CR149
  article-title: Compromised HOXA5 function can limit p53 expression in human breast tumours
  publication-title: Nature
– volume: 26
  start-page: 37
  issue: 1
  year: 2018
  end-page: 44
  ident: CR224
  article-title: Knockdown of homeobox B5 (HOXB5) inhibits cell proliferation, migration, and invasion in non-small cell lung cancer cells through inactivation of the Wnt/β-catenin pathway
  publication-title: Oncol Res
– volume: 472
  start-page: 393
  issue: 3
  year: 2015
  end-page: 403
  ident: CR66
  article-title: HOXB5 induces invasion and migration through direct transcriptional up-regulation of β-catenin in human gastric carcinoma
  publication-title: Biochem J
– volume: 5
  start-page: a006098
  issue: 4
  year: 2015
  ident: CR158
  article-title: Signal transduction in cancer
  publication-title: Cold Spring Harb Perspect. Med.
– volume: 10
  start-page: 10650
  issue: 10
  year: 2017
  end-page: 10665
  ident: CR223
  article-title: Upregulation of HOXA13 as a potential tumorigenesis and progression promoter of LUSC based on qRT-PCR and bioinformatics
  publication-title: Int J Clin Exp Pathol
– volume: 24
  start-page: 924
  issue: 2
  year: 2004
  end-page: 935
  ident: CR19
  article-title: HOXA5-induced apoptosis in breast cancer cells is mediated by caspases 2 and 8
  publication-title: Mol Cell Biol
– volume: 149
  start-page: 155
  issue: 1
  year: 2018
  end-page: 162
  ident: CR120
  article-title: HOXA4/HOXB3 gene expression signature as a biomarker of recurrence in patients with high-grade serous ovarian cancer following primary cytoreductive surgery and first-line adjuvant chemotherapy
  publication-title: Gynecol
– volume: 19
  start-page: 108
  issue: 1
  year: 2018
  ident: CR174
  article-title: Homeobox oncogene activation by pan-cancer DNA hypermethylation
  publication-title: Genome Biol
– volume: 36
  start-page: 107
  issue: 1
  year: 2003
  end-page: 112
  ident: CR137
  article-title: Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13)
  publication-title: Genes Chromosomes Cancer
– volume: 315
  start-page: C675
  issue: 5
  year: 2018
  end-page: C686
  ident: CR45
  article-title: Specific knockdown of HOXB7 inhibits cutaneous squamous cell carcinoma cell migration and invasion while inducing apoptosis via the Wnt/β-catenin signaling pathway
  publication-title: Am J Physiol Cell Physiol
– volume: 10
  start-page: 91
  year: 2012
  ident: CR15
  article-title: Increased HOX C13 expression in metastatic melanoma progression
  publication-title: J Transl Med
– volume: 19
  start-page: 156
  issue: 2
  year: 2009
  end-page: 172
  ident: CR203
  article-title: TGF-beta-induced epithelial to mesenchymal transition
  publication-title: Cell Res
– volume: 120
  start-page: 658
  issue: 1
  year: 2019
  end-page: 670
  ident: CR101
  article-title: Microarray-based analysis of whole-genome DNA methylation profiling in early detection of breast cancer
  publication-title: J Cell Biochem
– volume: 287
  start-page: 35678
  issue: 42
  year: 2012
  end-page: 35688
  ident: CR127
  article-title: HOXC6 is deregulated in human head and neck squamous cell carcinoma and modulates Bcl-2 expression
  publication-title: J Biol Chem
– volume: 39
  start-page: 874
  issue: 8
  year: 2015
  end-page: 882
  ident: CR3
  article-title: HOXA9 and MEIS1 gene overexpression in the diagnosis of childhood acute leukemias: significant correlation with relapse and overall survival
  publication-title: Leuk. Res. England
– volume: 73
  start-page: 114
  issue: 1-2
  year: 1996
  end-page: 115
  ident: CR7
  article-title: Fine mapping of human HOX gene clusters
  publication-title: Sytogenetics Cell Genet
– volume: 9
  start-page: 1613
  issue: 7
  year: 2020
  ident: CR135
  article-title: Methylation in HOX clusters and its applications in cancer therapy
  publication-title: Cells
– volume: 15
  start-page: 55
  issue: 1
  year: 2015
  end-page: 64
  ident: CR159
  article-title: HOXB9 promotes epithelial-to-mesenchymal transition via transforming growth factor-β1 pathway in hepatocellular carcinoma cells
  publication-title: Clin Exp Med
– volume: 285
  start-page: 2278
  issue: 12
  year: 2018
  end-page: 2291
  ident: CR96
  article-title: HOXC10 promotes proliferation and invasion and induces immunosuppressive gene expression in glioma
  publication-title: FEBS J
– volume: 7
  start-page: 1
  issue: 2
  year: 2018
  ident: CR110
  article-title: HOXC8 promotes proliferation and migration through transcriptional up-regulation of TGFβ1 in non-small cell lung cancer
  publication-title: Oncogenesis
– volume: 34
  start-page: 1203
  issue: 3
  year: 2015
  end-page: 10
  ident: CR188
  article-title: HOXA1 enhances the cell proliferation, invasion and metastasis of prostate cancer cells
  publication-title: Oncol. Rep.
– volume: 43
  start-page: 63
  issue: 1
  year: 2013
  end-page: 71
  ident: CR129
  article-title: Loss of HOXD10 expression induced by upregulation of miR-10b accelerates the migration and invasion activities of ovarian cancer cells
  publication-title: Int J Oncol
– volume: 27
  start-page: 60
  issue: 1
  year: 2019
  end-page: 66
  ident: CR51
  article-title: Overexpression of HOXC10 promotes glioblastoma cell progression to a poor prognosis via the PI3K/AKT signalling pathway
  publication-title: J Drug Target
– volume: 10
  start-page: e0130551
  issue: 6
  year: 2015
  ident: CR93
  article-title: Deregulated HOXB7 expression predicts poor prognosis of patients with esophageal squamous cell carcinoma and regulates cancer cell proliferation in vitro and in vivo
  publication-title: PLoS ONE
– volume: 6
  start-page: 229ra41
  issue: 229
  year: 2014
  ident: CR139
  article-title: Epigenetic reprogramming of HOXC10 in endocrine-resistant breast cancer
  publication-title: Sci. Transl. Med.
– volume: 10
  start-page: 3833
  issue: 8
  year: 2020
  end-page: 3848
  ident: CR32
  article-title: Interleukin 1β-mediated HOXC10 overexpression promotes hepatocellular carcinoma metastasis by upregulating PDPK1 and VASP
  publication-title: Theranostics
– volume: 304
  start-page: 75
  issue: 1
  year: 2005
  end-page: 85
  ident: CR183
  article-title: Evolution of microRNAs located within Hox gene clusters
  publication-title: J Exp Zool B Mol Dev Evol
– volume: 34
  start-page: 209
  issue: 3
  year: 2018
  end-page: 217
  ident: CR115
  article-title: Reassessing the role of Hox genes during vertebrate development and evolution
  publication-title: Trends Genet
– volume: 25
  start-page: 46
  issue: 1
  year: 2019
  end-page: 54
  ident: CR112
  article-title: High HOXD4 protein expression in gastric adenocarcinoma tissues indicates unfavorable clinical outcomes
  publication-title: Saudi J. Gastroenterol. off.
– volume: 689
  start-page: 18
  year: 2019
  end-page: 23
  ident: CR21
  article-title: HOXA5 overexpression promotes osteosarcoma cell apoptosis through the p53 and p38α MAPK pathway
  publication-title: Gene Netherlands
– volume: 8
  start-page: 9794
  issue: 6
  year: 2017
  end-page: 9805
  ident: CR200
  article-title: Homeobox A11 hypermethylation indicates unfavorable prognosis in breast cancer
  publication-title: Oncotarget
– volume: 17
  start-page: 4577
  issue: 6
  year: 2019
  end-page: 4585
  ident: CR97
  article-title: MicroRNA-10b-5p downregulation inhibits the invasion of glioma cells via modulating homeobox B3 expression
  publication-title: Exp Ther Med
– volume: 12
  start-page: S2588
  year: 2020
  ident: CR198
  article-title: Somatic HOXB13 expression correlates with metastatic progression in men with localized prostate cancer following radical prostatectomy
  publication-title: Eur Urol Oncol
– volume: 16
  start-page: 3941
  issue: 9
  year: 2015
  end-page: 4
  ident: CR228
  article-title: Aberrant expression of HOXA5 and HOXA9 in AML
  publication-title: Asian Pac J Cancer Prev
– volume: 1856
  start-page: 151
  issue: 1
  year: 2015
  end-page: 164
  ident: CR10
  article-title: LncRNA HOTAIR: a master regulator of chromatin dynamics and cancer
  publication-title: Biochim Biophys Acta
– volume: 4
  start-page: e586
  issue: 4
  year: 2013
  ident: CR87
  article-title: Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma
  publication-title: Cell Death Dis
– volume: 224
  start-page: 153117
  year: 2020
  ident: CR227
  article-title: HOXB5 promotes the progression of breast cancer through wnt/beta-catenin pathway
  publication-title: Pathol Res Pract
– volume: 29
  start-page: 601
  issue: 3
  year: 2015
  end-page: 8
  ident: CR233
  article-title: Hoxb7 promotes growth and metastasis of lung adenocarcinoma cells through regulation of the tgf-β/smad3 signaling
  publication-title: J Biol Regul Homeost Agents
– volume: 8
  start-page: 1360
  issue: 11
  year: 2019
  ident: CR58
  article-title: HOXA9 transcriptionally promotes apoptosis and represses autophagy by targeting NF-κB in cutaneous squamous cell carcinoma
  publication-title: Cells
– volume: 44
  start-page: 7331
  issue: 15
  year: 2016
  end-page: 7349
  ident: CR181
  article-title: HOXA1 binds RBCK1/HOIL-1 and TRAF2 and modulates the TNF/NF-κB pathway in a transcription-independent manner
  publication-title: Nucleic Acids Res
– volume: 18
  start-page: 221
  issue: 2
  year: 2012
  end-page: 223
  ident: CR126
  article-title: Identification of a mutation in the extracellular domain of the epidermal growth factor receptor conferring cetuximab resistance in colorectal cancer
  publication-title: Nat Med
– volume: 19
  start-page: 3
  year: 2019
  ident: CR191
  article-title: HOXB8 enhances the proliferation and metastasis of colorectal cancer cells by promoting EMT via STAT3 activation
  publication-title: Cancer Cell Int
– volume: 9
  start-page: 9715
  issue: 1
  year: 2019
  ident: CR215
  article-title: The homeobox gene, HOXB13, regulates a mitotic protein-kinase interaction network in metastatic prostate cancers
  publication-title: Sci Rep
– volume: 4
  start-page: 24
  year: 2018
  ident: CR105
  article-title: HOXC8: a predictive glioma biomarker that induces epithelia-mesenchymal transition
  publication-title: Chinese Neurosurg J
– volume: 12
  start-page: 3299
  issue: 11
  year: 2020
  ident: CR26
  article-title: HOX genes family and cancer: a novel role for homeobox B9 in the resistance to anti-angiogenic therapies
  publication-title: Cancers (basel).
– volume: 54
  start-page: E72
  issue: Suppl 1
  year: 2015
  end-page: 80
  ident: CR74
  article-title: HOXA9 inhibits migration of lung cancer cells and its hypermethylation is associated with recurrence in non-small cell lung cancer
  publication-title: Mol Carcinog
– volume: 51
  start-page: 450
  issue: 9
  year: 2018
  end-page: 5
  ident: CR211
  article-title: Up-regulation of HOXB cluster genes are epigenetically regulated in tamoxifen-resistant MCF7 breast cancer cells
  publication-title: BMB Rep.
– volume: 4
  start-page: 1933
  issue: 11
  year: 2013
  end-page: 1947
  ident: CR14
  article-title: HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia
  publication-title: Oncotarget
– volume: 1
  start-page: 67
  issue: 2–3
  year: 2013
  end-page: 76
  ident: CR60
  article-title: Homeobox gene deregulation: impact on the hallmarks of cancer
  publication-title: Cancer Hallm
– volume: 70
  start-page: 453
  issue: 2
  year: 2010
  end-page: 462
  ident: CR27
  article-title: Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma
  publication-title: Cancer Res
– volume: 291
  start-page: 193
  issue: 2
  year: 2006
  end-page: 206
  ident: CR123
  article-title: Hox cofactors in vertebrate development
  publication-title: Dev Biol
– volume: 503
  start-page: 2924
  issue: 4
  year: 2018
  end-page: 2930
  ident: CR90
  article-title: Transcriptional activation of EGFR by HOXB5 and its role in breast cancer cell invasion
  publication-title: Biochem Biophys. Res. Commun.
– volume: 13
  start-page: 2163
  year: 2020
  end-page: 2172
  ident: CR202
  article-title: HOXD9 activates the TGF-β/Smad signaling pathway to promote gastric cancer
  publication-title: Onco Targets Ther
– volume: 117
  start-page: 7296
  issue: 13
  year: 2020
  end-page: 7304
  ident: CR172
  article-title: Hox genes maintain critical roles in the adult skeleton
  publication-title: Proc Natl Acad Sci U S A
– volume: 107
  start-page: 1100
  issue: 3
  year: 2010
  end-page: 1105
  ident: CR61
  article-title: HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis
  publication-title: Proc Natl Acad Sci U S A
– volume: 22
  start-page: 3157
  issue: 9
  year: 2002
  end-page: 3173
  ident: CR31
  article-title: Molecular mechanisms of gene silencing mediated by DNA methylation
  publication-title: Mol Cell Biol
– volume: 76
  start-page: 4443
  issue: 15
  year: 2016
  end-page: 4456
  ident: CR153
  article-title: HOXC10 expression supports the development of chemotherapy resistance by fine tuning DNA repair in breast cancer cells
  publication-title: Cancer Res
– volume: 53
  start-page: 49
  issue: 1
  year: 2014
  end-page: 57
  ident: CR217
  article-title: Role of HOXB7 in regulation of progression and metastasis of human lung adenocarcinoma
  publication-title: Mol Carcinog
– volume: 13
  start-page: 2348
  issue: 9
  year: 2020
  end-page: 2351
  ident: CR155
  article-title: Immunohistochemical detection of paralogous 13 HOX genes in phyllodes tumor of the breast as a useful diagnostic tool
  publication-title: Int J Clin Exp Pathol
– volume: 66
  start-page: 794
  issue: 6
  year: 2020
  end-page: 799
  ident: CR104
  article-title: Homeobox B2 is a potential prognostic biomarker of glioblastoma
  publication-title: Rev Assoc Med Bras
– volume: 854
  start-page: 22
  year: 2019
  end-page: 27
  ident: CR54
  article-title: Knockdown of HOXB8 inhibits tumor growth and metastasis by the inactivation of Wnt/β-catenin signaling pathway in osteosarcoma
  publication-title: Eur J Pharmacol Netherlands
– volume: 33
  start-page: 3901
  issue: 3
  year: 2019
  end-page: 11
  ident: CR192
  article-title: HOXC6 promotes cervical cancer progression via regulation of Bcl-2
  publication-title: FASEB J Off Publ Fed Am Soc Exp Biol
– volume: 11
  start-page: 2946
  issue: 11
  year: 2015
  end-page: 2954
  ident: CR40
  article-title: HOXC10 up-regulation contributes to human thyroid cancer and indicates poor survival outcome
  publication-title: Mol Biosyst
– volume: 588
  start-page: 2558
  issue: 16
  year: 2014
  end-page: 2570
  ident: CR49
  article-title: Deregulation of cell signaling in cancer
  publication-title: FEBS Lett
– volume: 40
  start-page: 1317
  issue: 3
  year: 2018
  end-page: 1329
  ident: CR140
  article-title: HOXA5 is a tumor suppressor gene that is decreased in gastric cancer
  publication-title: Oncol Rep
– volume: 20
  start-page: 586
  issue: 1
  year: 2020
  ident: CR55
  article-title: Overexpression of HOXA10 is associated with unfavorable prognosis of acute myeloid leukemia
  publication-title: BMC Cancer
– volume: 57
  start-page: 722
  issue: 6
  year: 2018
  end-page: 734
  ident: CR57
  article-title: HOXA13 contributes to gastric carcinogenesis through DHRS2 interacting with MDM2 and confers 5-FU resistance by a p53-dependent pathway
  publication-title: Mol Carcinog
– volume: 45
  start-page: 1246
  issue: 6
  year: 2021
  end-page: 1259
  ident: CR30
  article-title: HOXD1 functions as a novel tumor suppressor in kidney renal clear cell carcinoma
  publication-title: Cell Biol Int
– volume: 6
  start-page: 7657
  issue: 10
  year: 2015
  end-page: 7674
  ident: CR143
  article-title: A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide
  publication-title: Oncotarget
– volume: 19
  start-page: 52
  issue: 1
  year: 2016
  end-page: 65
  ident: CR156
  article-title: Persistent activation of NF-κB in BRCA1-deficient mammary progenitors drives aberrant proliferation and accumulation of DNA damage
  publication-title: Cell Stem Cell
– volume: 20
  start-page: 833
  issue: 6
  year: 2013
  end-page: 839
  ident: CR118
  article-title: Deregulation of HOX B13 expression in urinary bladder cancer progression
  publication-title: Curr Med Chem
– volume: 13
  start-page: 2348
  issue: 9
  year: 2020
  ident: 9657_CR155
  publication-title: Int J Clin Exp Pathol
– volume: 224
  start-page: 153117
  year: 2020
  ident: 9657_CR227
  publication-title: Pathol Res Pract
  doi: 10.1016/j.prp.2020.153117
– volume: 70
  start-page: 453
  issue: 2
  year: 2010
  ident: 9657_CR27
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-09-2189
– volume: 29
  start-page: 572
  issue: 6
  year: 2017
  ident: 9657_CR52
  publication-title: Chin J Cancer Res
  doi: 10.21147/j.issn.1000-9604.2017.06.12
– volume: 24
  start-page: 6265
  issue: 24
  year: 2018
  ident: 9657_CR169
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-18-0444
– volume: 9
  start-page: 465
  issue: 5
  year: 2018
  ident: 9657_CR22
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-018-0497-x
– volume: 11
  start-page: 2946
  issue: 11
  year: 2015
  ident: 9657_CR40
  publication-title: Mol Biosyst
  doi: 10.1039/C5MB00253B
– volume: 9
  start-page: 1151
  issue: 3
  year: 2017
  ident: 9657_CR208
  publication-title: Am J Transl Res
– volume: 21
  start-page: 798
  issue: 5
  year: 2002
  ident: 9657_CR122
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1205126
– volume: 64
  start-page: 3046
  issue: 9
  year: 2004
  ident: 9657_CR78
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-03-2614
– volume: 33
  start-page: 1868
  issue: 8
  year: 2019
  ident: 9657_CR165
  publication-title: Leukemia
  doi: 10.1038/s41375-018-0361-0
– volume: 24
  start-page: 245
  issue: 2
  year: 2018
  ident: 9657_CR2
  publication-title: Pathol Oncol Res Switzerland
  doi: 10.1007/s12253-017-0243-1
– volume: 66
  start-page: 6628
  issue: 13
  year: 2006
  ident: 9657_CR180
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-06-0458
– volume: 29
  start-page: 601
  issue: 3
  year: 2015
  ident: 9657_CR233
  publication-title: J Biol Regul Homeost Agents
– volume: 73
  start-page: 114
  issue: 1-2
  year: 1996
  ident: 9657_CR7
  publication-title: Sytogenetics Cell Genet
  doi: 10.1159/000134320
– volume: 12
  start-page: 3299
  issue: 11
  year: 2020
  ident: 9657_CR26
  publication-title: Cancers (basel).
  doi: 10.3390/cancers12113299
– volume: 25
  start-page: 7492
  issue: 57
  year: 2006
  ident: 9657_CR8
  publication-title: Oncogene England
  doi: 10.1038/sj.onc.1210056
– volume: 118
  start-page: 6247
  issue: 24
  year: 2011
  ident: 9657_CR50
  publication-title: Blood
  doi: 10.1182/blood-2011-07-328880
– volume: 503
  start-page: 2924
  issue: 4
  year: 2018
  ident: 9657_CR90
  publication-title: Biochem Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2018.08.071
– volume: 53
  start-page: 1557
  issue: 4
  year: 2018
  ident: 9657_CR44
  publication-title: Int J Oncol
– volume: 20
  start-page: 127
  issue: 1
  year: 2019
  ident: 9657_CR63
  publication-title: BMC Nephrol
  doi: 10.1186/s12882-019-1322-1
– volume: 73
  start-page: 5449
  issue: 17
  year: 2013
  ident: 9657_CR162
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-13-1178
– volume: 77
  start-page: 3181
  issue: 12
  year: 2017
  ident: 9657_CR114
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-16-2797
– volume: 10
  start-page: 361
  issue: 5
  year: 2010
  ident: 9657_CR160
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc2826
– volume: 36
  start-page: 107
  issue: 1
  year: 2003
  ident: 9657_CR137
  publication-title: Genes Chromosomes Cancer
  doi: 10.1002/gcc.10139
– volume: 8
  start-page: 1500
  issue: 9
  year: 2019
  ident: 9657_CR131
  publication-title: J Clin Med
  doi: 10.3390/jcm8091500
– volume: 689
  start-page: 18
  year: 2019
  ident: 9657_CR21
  publication-title: Gene Netherlands
– volume: 1
  start-page: 67
  issue: 2–3
  year: 2013
  ident: 9657_CR60
  publication-title: Cancer Hallm
  doi: 10.1166/ch.2013.1007
– volume: 20
  start-page: 833
  issue: 6
  year: 2013
  ident: 9657_CR118
  publication-title: Curr Med Chem
– volume: 26
  start-page: 37
  issue: 1
  year: 2018
  ident: 9657_CR224
  publication-title: Oncol Res
  doi: 10.3727/096504017X14900530835262
– volume: 40
  start-page: 1317
  issue: 3
  year: 2018
  ident: 9657_CR140
  publication-title: Oncol Rep
– volume: 12
  start-page: 1803
  year: 2019
  ident: 9657_CR144
  publication-title: Onco Targets Ther
  doi: 10.2147/OTT.S196986
– volume: 9
  start-page: 1613
  issue: 7
  year: 2020
  ident: 9657_CR135
  publication-title: Cells
  doi: 10.3390/cells9071613
– volume: 16
  start-page: 85
  year: 2016
  ident: 9657_CR128
  publication-title: BMC Cancer
  doi: 10.1186/s12885-016-2106-7
– volume: 12
  start-page: 6861
  issue: 5
  year: 2015
  ident: 9657_CR94
  publication-title: Mol Med Rep
  doi: 10.3892/mmr.2015.4331
– volume: 43
  start-page: 63
  issue: 1
  year: 2013
  ident: 9657_CR129
  publication-title: Int J Oncol
  doi: 10.3892/ijo.2013.1935
– volume: 75
  start-page: 23
  issue: 1
  year: 2006
  ident: 9657_CR88
  publication-title: Ulster Med J
– volume: 33
  start-page: 4558
  issue: 37
  year: 2014
  ident: 9657_CR82
  publication-title: Oncogene
  doi: 10.1038/onc.2013.404
– volume: 11
  start-page: 39
  issue: 1
  year: 2019
  ident: 9657_CR195
  publication-title: Clin Epigenetics
  doi: 10.1186/s13148-019-0634-0
– volume: 9
  start-page: 116
  year: 2017
  ident: 9657_CR53
  publication-title: Clin Epigenetics
  doi: 10.1186/s13148-017-0412-9
– volume: 117
  start-page: 7296
  issue: 13
  year: 2020
  ident: 9657_CR172
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1920860117
– volume: 18
  start-page: 31
  issue: 1
  year: 2019
  ident: 9657_CR212
  publication-title: Mol Cancer
  doi: 10.1186/s12943-019-0955-9
– volume: 39
  start-page: 874
  issue: 8
  year: 2015
  ident: 9657_CR3
  publication-title: Leuk. Res. England
  doi: 10.1016/j.leukres.2015.04.012
– volume: 144
  start-page: 646
  issue: 5
  year: 2011
  ident: 9657_CR59
  publication-title: Cell
  doi: 10.1016/j.cell.2011.02.013
– volume: 37
  start-page: 424
  issue: 4
  year: 2013
  ident: 9657_CR4
  publication-title: Cancer Epidemiol
  doi: 10.1016/j.canep.2013.03.003
– volume: 12
  start-page: 420
  issue: 4
  year: 2014
  ident: 9657_CR142
  publication-title: Curr Osteoporos Rep
  doi: 10.1007/s11914-014-0241-0
– volume: 46
  start-page: 1066
  issue: 6
  year: 2020
  ident: 9657_CR91
  publication-title: Eur. J. Surg. Oncol. J. Eur. Soc.
  doi: 10.1016/j.ejso.2019.12.009
– volume: 19
  start-page: 52
  issue: 1
  year: 2016
  ident: 9657_CR156
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2016.05.003
– volume: 13
  start-page: 2163
  year: 2020
  ident: 9657_CR202
  publication-title: Onco Targets Ther
  doi: 10.2147/OTT.S234829
– volume: 41
  start-page: 2285
  issue: 6
  year: 2012
  ident: 9657_CR67
  publication-title: Int J Oncol
  doi: 10.3892/ijo.2012.1660
– volume: 47
  start-page: 1058
  issue: 6
  year: 2020
  ident: 9657_CR175
  publication-title: Clin Exp Pharmacol Physiol
  doi: 10.1111/1440-1681.13278
– volume: 13
  start-page: 1111
  issue: 6A
  year: 2003
  ident: 9657_CR154
  publication-title: Genome Res
  doi: 10.1101/gr.700503
– volume: 234
  start-page: 209
  issue: 3
  year: 2014
  ident: 9657_CR136
  publication-title: Tohoku J Exp Med
  doi: 10.1620/tjem.234.209
– volume: 6
  start-page: 229ra41
  issue: 229
  year: 2014
  ident: 9657_CR139
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3008326
– volume: 66
  start-page: 794
  issue: 6
  year: 2020
  ident: 9657_CR104
  publication-title: Rev Assoc Med Bras
  doi: 10.1590/1806-9282.66.6.794
– volume: 49
  start-page: 387
  issue: 2
  year: 2017
  ident: 9657_CR157
  publication-title: Cancer Res Treat
  doi: 10.4143/crt.2016.106
– volume: 9
  start-page: 9715
  issue: 1
  year: 2019
  ident: 9657_CR215
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-46064-4
– volume: 292
  start-page: 17681
  issue: 43
  year: 2017
  ident: 9657_CR185
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M116.772780
– volume: 8
  start-page: 9794
  issue: 6
  year: 2017
  ident: 9657_CR200
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.14216
– volume: 10
  start-page: e0130551
  issue: 6
  year: 2015
  ident: 9657_CR93
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0130551
– volume: 51
  start-page: 157
  issue: 1
  year: 2019
  ident: 9657_CR226
  publication-title: Dig. liver Dis
  doi: 10.1016/j.dld.2018.08.018
– volume: 2017
  start-page: 3680305
  year: 2017
  ident: 9657_CR176
  publication-title: Biomed Res Int
  doi: 10.1155/2017/3680305
– volume: 31
  start-page: 828
  issue: 8
  year: 2020
  ident: 9657_CR47
  publication-title: Anticancer Drugs
  doi: 10.1097/CAD.0000000000000948
– volume: 291
  start-page: 193
  issue: 2
  year: 2006
  ident: 9657_CR123
  publication-title: Dev Biol
  doi: 10.1016/j.ydbio.2005.10.032
– volume: 218
  start-page: 1
  year: 2019
  ident: 9657_CR230
  publication-title: Life Sci Netherlands
  doi: 10.1016/j.lfs.2018.12.011
– volume: 122
  start-page: 3603
  issue: 10
  year: 2012
  ident: 9657_CR86
  publication-title: J Clin Invest
  doi: 10.1172/JCI62229
– volume: 17
  start-page: 3569
  issue: 11
  year: 2011
  ident: 9657_CR106
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-10-2533
– volume: 854
  start-page: 22
  year: 2019
  ident: 9657_CR54
  publication-title: Eur J Pharmacol Netherlands
  doi: 10.1016/j.ejphar.2019.04.004
– volume: 108
  start-page: 4914
  issue: 12
  year: 2011
  ident: 9657_CR6
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1102300108
– volume: 7
  start-page: 1
  issue: 2
  year: 2018
  ident: 9657_CR110
  publication-title: Oncogenesis
  doi: 10.1038/s41389-017-0016-4
– volume: 11
  start-page: 2612
  issue: 6
  year: 2021
  ident: 9657_CR41
  publication-title: Theranostics
  doi: 10.7150/thno.52199
– volume: 4
  start-page: 1933
  issue: 11
  year: 2013
  ident: 9657_CR14
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.1306
– volume: 44
  start-page: 7331
  issue: 15
  year: 2016
  ident: 9657_CR181
  publication-title: Nucleic Acids Res
– volume: 98
  start-page: 95
  issue: 1
  year: 2018
  ident: 9657_CR147
  publication-title: Lab Invest
  doi: 10.1038/labinvest.2017.107
– volume: 76
  start-page: 4443
  issue: 15
  year: 2016
  ident: 9657_CR153
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-16-0774
– volume: 119
  start-page: 1420
  issue: 6
  year: 2009
  ident: 9657_CR81
  publication-title: J Clin Invest
  doi: 10.1172/JCI39104
– volume: 304
  start-page: 75
  issue: 1
  year: 2005
  ident: 9657_CR183
  publication-title: J Exp Zool B Mol Dev Evol
  doi: 10.1002/jez.b.21021
– volume: 311
  start-page: C1
  issue: 1
  year: 2016
  ident: 9657_CR23
  publication-title: Am J Physiol Cell Physiol
  doi: 10.1152/ajpcell.00238.2015
– volume: 410
  start-page: 68
  year: 2017
  ident: 9657_CR43
  publication-title: Cancer Lett Ireland
  doi: 10.1016/j.canlet.2017.09.019
– volume: 34
  start-page: 209
  issue: 3
  year: 2018
  ident: 9657_CR115
  publication-title: Trends Genet
  doi: 10.1016/j.tig.2017.11.007
– volume: 10
  start-page: 368
  year: 2020
  ident: 9657_CR103
  publication-title: Front Oncol
  doi: 10.3389/fonc.2020.00368
– volume: 12
  start-page: 3
  issue: 1
  year: 2018
  ident: 9657_CR167
  publication-title: Mol Oncol
  doi: 10.1002/1878-0261.12155
– volume: 22
  start-page: 390
  issue: 6
  year: 2018
  ident: 9657_CR219
  publication-title: Genet Test Mol Biomarkers
  doi: 10.1089/gtmb.2017.0240
– volume: 8
  start-page: 616
  issue: 5
  year: 2018
  ident: 9657_CR34
  publication-title: Cancer Discov
  doi: 10.1158/2159-8290.CD-17-0583
– volume: 23
  start-page: 2476
  issue: 6
  year: 2019
  ident: 9657_CR73
  publication-title: Eur Rev Med Pharmacol Sci
– volume: 18
  start-page: 221
  issue: 2
  year: 2012
  ident: 9657_CR126
  publication-title: Nat Med
  doi: 10.1038/nm.2609
– volume: 113
  start-page: 365
  issue: 3
  year: 2015
  ident: 9657_CR184
  publication-title: Br J Cancer
  doi: 10.1038/bjc.2015.233
– volume: 111
  start-page: 4
  issue: 1
  year: 2014
  ident: 9657_CR148
  publication-title: Mol Genet Metab
  doi: 10.1016/j.ymgme.2013.10.012
– volume: 18
  start-page: 49
  issue: 1
  year: 2019
  ident: 9657_CR111
  publication-title: Oncol Lett
– volume: 71
  start-page: 427
  issue: 5–6
  year: 2010
  ident: 9657_CR119
  publication-title: J Mol Evol
  doi: 10.1007/s00239-010-9396-1
– volume: 137
  start-page: 2136
  issue: 6
  year: 2009
  ident: 9657_CR199
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2009.08.065
– volume: 45
  start-page: 1246
  issue: 6
  year: 2021
  ident: 9657_CR30
  publication-title: Cell Biol Int
  doi: 10.1002/cbin.11568
– volume: 92
  start-page: 2233
  issue: 12
  year: 2005
  ident: 9657_CR79
  publication-title: Br J Cancer
  doi: 10.1038/sj.bjc.6602631
– volume: 8
  start-page: 5143
  issue: 18
  year: 2018
  ident: 9657_CR182
  publication-title: Theranostics
  doi: 10.7150/thno.27310
– volume: 61
  start-page: 6532
  issue: 17
  year: 2001
  ident: 9657_CR16
  publication-title: Cancer Res
– volume: 405
  start-page: 974
  issue: 6789
  year: 2000
  ident: 9657_CR149
  publication-title: Nature
  doi: 10.1038/35016125
– volume: 10
  start-page: 10650
  issue: 10
  year: 2017
  ident: 9657_CR223
  publication-title: Int J Clin Exp Pathol
– volume: 57
  start-page: 722
  issue: 6
  year: 2018
  ident: 9657_CR57
  publication-title: Mol Carcinog
  doi: 10.1002/mc.22793
– volume: 287
  start-page: 35678
  issue: 42
  year: 2012
  ident: 9657_CR127
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M112.361675
– volume: 20
  start-page: 586
  issue: 1
  year: 2020
  ident: 9657_CR55
  publication-title: BMC Cancer
  doi: 10.1186/s12885-020-07088-6
– volume: 129
  start-page: 1311
  issue: 7
  year: 2007
  ident: 9657_CR151
  publication-title: Cell
  doi: 10.1016/j.cell.2007.05.022
– volume: 59
  start-page: 1442
  issue: 7
  year: 2014
  ident: 9657_CR28
  publication-title: Dig Dis Sci
  doi: 10.1007/s10620-014-3033-6
– volume: 2
  start-page: 31
  issue: 1
  year: 2013
  ident: 9657_CR64
  publication-title: Wiley Interdiscip Rev Dev Biol
  doi: 10.1002/wdev.78
– volume: 25
  start-page: 22
  year: 2017
  ident: 9657_CR166
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2017.09.029
– volume: 10
  start-page: e0124191
  issue: 4
  year: 2015
  ident: 9657_CR187
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0124191
– volume: 154
  start-page: 1269
  issue: 6
  year: 2013
  ident: 9657_CR197
  publication-title: Cell
  doi: 10.1016/j.cell.2013.08.015
– volume: 62
  start-page: 6240
  issue: 21
  year: 2002
  ident: 9657_CR75
  publication-title: Cancer Res
– volume: 26
  start-page: 3998
  issue: 27
  year: 2007
  ident: 9657_CR124
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1210180
– volume: 234
  start-page: 395
  issue: 1
  year: 2018
  ident: 9657_CR13
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.27036
– volume: 49
  start-page: 2529
  issue: 6
  year: 2016
  ident: 9657_CR189
  publication-title: Int. J. Oncol.
  doi: 10.3892/ijo.2016.3738
– volume: 8
  start-page: 13483
  issue: 1
  year: 2018
  ident: 9657_CR178
  publication-title: Sci Rep
  doi: 10.1038/s41598-018-31030-3
– volume: 588
  start-page: 2558
  issue: 16
  year: 2014
  ident: 9657_CR49
  publication-title: FEBS Lett
  doi: 10.1016/j.febslet.2014.02.005
– volume: 9
  start-page: 205
  issue: 2
  year: 2019
  ident: 9657_CR76
  publication-title: Adv. Pharm. Bull
  doi: 10.15171/apb.2019.024
– volume: 25
  start-page: 384
  issue: 4
  year: 2005
  ident: 9657_CR186
  publication-title: Hum Mutat
  doi: 10.1002/humu.20155
– volume: 26
  start-page: 1535
  issue: 5
  year: 2019
  ident: 9657_CR121
  publication-title: Ann Surg Oncol
  doi: 10.1245/s10434-019-07166-5
– volume: 33
  start-page: 1017
  issue: 8
  year: 2014
  ident: 9657_CR194
  publication-title: Oncogene
  doi: 10.1038/onc.2013.30
– volume: 11
  start-page: 8167
  year: 2019
  ident: 9657_CR213
  publication-title: Cancer Manag Res
  doi: 10.2147/CMAR.S209904
– volume: 59
  start-page: 911
  issue: 3
  year: 2014
  ident: 9657_CR146
  publication-title: Hepatology
  doi: 10.1002/hep.26740
– volume: 117
  start-page: 1279
  issue: 6
  year: 2016
  ident: 9657_CR179
  publication-title: J Cell Biochem.
  doi: 10.1002/jcb.25496
– volume: 25
  start-page: 46
  issue: 1
  year: 2019
  ident: 9657_CR112
  publication-title: Saudi J. Gastroenterol. off.
  doi: 10.4103/sjg.SJG_105_18
– volume: 15
  start-page: 7291
  issue: 5
  year: 2018
  ident: 9657_CR72
  publication-title: Oncol Lett
– volume: 16
  start-page: 3941
  issue: 9
  year: 2015
  ident: 9657_CR228
  publication-title: Asian Pac J Cancer Prev
  doi: 10.7314/APJCP.2015.16.9.3941
– volume: 13
  start-page: 10
  issue: 1
  year: 2020
  ident: 9657_CR134
  publication-title: Cancers
  doi: 10.3390/cancers13010010
– volume: 17
  start-page: 1037
  issue: 3
  year: 2016
  ident: 9657_CR5
  publication-title: Asian Pac. J. Cancer Prev. Thailand
  doi: 10.7314/APJCP.2016.17.3.1037
– volume: 9
  start-page: 836
  issue: 7
  year: 2018
  ident: 9657_CR164
  publication-title: Thorac Cancer
  doi: 10.1111/1759-7714.12758
– volume: 9
  start-page: 394
  year: 2019
  ident: 9657_CR100
  publication-title: Front Oncol
  doi: 10.3389/fonc.2019.00394
– volume: 34
  start-page: 1203
  issue: 3
  year: 2015
  ident: 9657_CR188
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2015.4085
– volume: 12
  start-page: 348
  year: 2012
  ident: 9657_CR107
  publication-title: BMC Cancer
  doi: 10.1186/1471-2407-12-348
– volume: 33
  start-page: 3901
  issue: 3
  year: 2019
  ident: 9657_CR192
  publication-title: FASEB J Off Publ Fed Am Soc Exp Biol
– volume: 22
  start-page: 414
  issue: 5
  year: 2016
  ident: 9657_CR25
  publication-title: Trends Mol Med
  doi: 10.1016/j.molmed.2016.03.002
– volume: 4
  start-page: e586
  issue: 4
  year: 2013
  ident: 9657_CR87
  publication-title: Cell Death Dis
  doi: 10.1038/cddis.2013.84
– volume: 315
  start-page: C675
  issue: 5
  year: 2018
  ident: 9657_CR45
  publication-title: Am J Physiol Cell Physiol
  doi: 10.1152/ajpcell.00291.2017
– volume: 18
  start-page: 819
  issue: 6
  year: 2016
  ident: 9657_CR207
  publication-title: Neuro Oncol
  doi: 10.1093/neuonc/nov281
– volume: 214
  start-page: 1818
  issue: 11
  year: 2018
  ident: 9657_CR209
  publication-title: Pathol Res Pract
  doi: 10.1016/j.prp.2018.09.001
– volume: 31
  start-page: 225
  issue: 6
  year: 2016
  ident: 9657_CR20
  publication-title: Cancer Biother Radiopharm
– volume: 107
  start-page: 1100
  issue: 3
  year: 2010
  ident: 9657_CR61
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0912710107
– volume: 21
  start-page: 1234
  issue: 6
  year: 2017
  ident: 9657_CR145
  publication-title: Eur Rev Med Pharmacol Sci
– volume: 11
  start-page: 3416
  issue: 12
  year: 2020
  ident: 9657_CR84
  publication-title: J Cancer
  doi: 10.7150/jca.38728
– volume: 41
  start-page: 1122
  issue: 2
  year: 2019
  ident: 9657_CR193
  publication-title: Oncol Rep
– volume: 142
  start-page: 1212
  issue: 7
  year: 2015
  ident: 9657_CR150
  publication-title: Development
  doi: 10.1242/dev.109785
– volume: 472
  start-page: 393
  issue: 3
  year: 2015
  ident: 9657_CR66
  publication-title: Biochem J
  doi: 10.1042/BJ20150213
– volume: 301
  start-page: 331
  issue: 5631
  year: 2003
  ident: 9657_CR85
  publication-title: Science
  doi: 10.1126/science.1085753
– volume: 109
  start-page: 2736
  issue: 8
  year: 2012
  ident: 9657_CR77
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1018859108
– volume: 6
  start-page: 10
  year: 2006
  ident: 9657_CR71
  publication-title: Cancer Cell Int
  doi: 10.1186/1475-2867-6-10
– volume: 285
  start-page: 2278
  issue: 12
  year: 2018
  ident: 9657_CR96
  publication-title: FEBS J
  doi: 10.1111/febs.14476
– volume: 148
  start-page: 3060
  issue: 15
  year: 2021
  ident: 9657_CR206
  publication-title: Int J cancer
  doi: 10.1002/ijc.33494
– volume: 17
  start-page: 9
  issue: 1
  year: 2019
  ident: 9657_CR220
  publication-title: Cell Commun Signal
  doi: 10.1186/s12964-018-0316-0
– volume: 24
  start-page: 924
  issue: 2
  year: 2004
  ident: 9657_CR19
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.24.2.924-935.2004
– volume: 88
  start-page: 1
  year: 2017
  ident: 9657_CR117
  publication-title: Int J Biochem Cell Biol Netherlands
  doi: 10.1016/j.biocel.2017.04.011
– volume: 36
  start-page: 86
  issue: 1
  year: 2017
  ident: 9657_CR70
  publication-title: J Exp Clin Cancer Res
  doi: 10.1186/s13046-017-0559-4
– volume: 8
  start-page: 1647
  issue: 9
  year: 2017
  ident: 9657_CR18
  publication-title: J Cancer
  doi: 10.7150/jca.18893
– volume: 37
  start-page: 265
  issue: 1
  year: 2018
  ident: 9657_CR95
  publication-title: J Exp Clin Cancer Res
  doi: 10.1186/s13046-018-0941-x
– volume: 2
  start-page: 401
  issue: 5
  year: 2012
  ident: 9657_CR17
  publication-title: Cancer Discov
  doi: 10.1158/2159-8290.CD-12-0095
– volume: 17
  start-page: 4577
  issue: 6
  year: 2019
  ident: 9657_CR97
  publication-title: Exp Ther Med
– volume: 75
  start-page: 709
  issue: 4
  year: 2015
  ident: 9657_CR108
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-14-3100
– volume: 19
  start-page: 1997
  issue: 3
  year: 2020
  ident: 9657_CR56
  publication-title: Exp Ther Med
– volume: 286
  start-page: 3161
  issue: 4
  year: 2011
  ident: 9657_CR161
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M110.183251
– volume: 15
  start-page: e0236811
  issue: 8
  year: 2020
  ident: 9657_CR80
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0236811
– volume: 25
  start-page: 2044
  issue: 12
  year: 2020
  ident: 9657_CR229
  publication-title: Int J Clin Oncol
  doi: 10.1007/s10147-020-01772-0
– volume: 11
  start-page: 3071
  issue: 11
  year: 2020
  ident: 9657_CR232
  publication-title: Thorac Cancer
  doi: 10.1111/1759-7714.13142
– volume: 129
  start-page: 391
  issue: 11–12
  year: 2017
  ident: 9657_CR68
  publication-title: Wien Klin. Wochenschr
  doi: 10.1007/s00508-016-1108-4
– volume: 6
  start-page: 1
  issue: 269
  year: 2013
  ident: 9657_CR46
  publication-title: Sci Signal.
  doi: 10.1126/scisignal.2004088
– volume: 501
  start-page: 628
  issue: 3
  year: 2018
  ident: 9657_CR214
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2018.05.019
– volume: 27
  start-page: 60
  issue: 1
  year: 2019
  ident: 9657_CR51
  publication-title: J Drug Target
  doi: 10.1080/1061186X.2018.1473408
– volume: 393
  start-page: 195
  issue: 2
  year: 2014
  ident: 9657_CR221
  publication-title: Dev Biol
  doi: 10.1016/j.ydbio.2014.07.004
– volume: 36
  start-page: 2821
  issue: 4
  year: 2015
  ident: 9657_CR109
  publication-title: Tumour Biol J Int Soc Oncodevelopmental Biol Med
  doi: 10.1007/s13277-014-2909-6
– volume: 120
  start-page: 658
  issue: 1
  year: 2019
  ident: 9657_CR101
  publication-title: J Cell Biochem
  doi: 10.1002/jcb.27423
– volume: 71
  start-page: 461
  issue: 8
  year: 2003
  ident: 9657_CR65
  publication-title: Differentiation
  doi: 10.1046/j.1432-0436.2003.7108004.x
– volume: 2
  start-page: 33
  issue: 1
  year: 2001
  ident: 9657_CR42
  publication-title: Nat Rev Genet
  doi: 10.1038/35047605
– volume: 15
  start-page: 2756
  issue: 3
  year: 2018
  ident: 9657_CR196
  publication-title: Oncol Lett
– volume: 6
  start-page: 27778
  issue: 29
  year: 2015
  ident: 9657_CR37
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.4813
– volume: 5
  start-page: 619
  issue: 5
  year: 1995
  ident: 9657_CR12
  publication-title: Curr Opin. Genet. Dev
  doi: 10.1016/0959-437X(95)80031-X
– volume: 147
  start-page: 1740
  issue: 6
  year: 2020
  ident: 9657_CR168
  publication-title: Int J Cancer
  doi: 10.1002/ijc.32984
– volume: 46
  start-page: 1737
  issue: 4
  year: 2018
  ident: 9657_CR225
  publication-title: Cell. Physiol. Biochem
  doi: 10.1159/000489249
– volume: 5
  start-page: a006098
  issue: 4
  year: 2015
  ident: 9657_CR158
  publication-title: Cold Spring Harb Perspect. Med.
  doi: 10.1101/cshperspect.a006098
– volume: 22
  start-page: 3157
  issue: 9
  year: 2002
  ident: 9657_CR31
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.22.9.3157-3173.2002
– volume: 10
  start-page: 1152
  year: 2020
  ident: 9657_CR152
  publication-title: Front Oncol
  doi: 10.3389/fonc.2020.01152
– volume: 8
  start-page: 41415
  year: 2018
  ident: 9657_CR177
  publication-title: RSC Adv
  doi: 10.1039/C8RA06860G
– volume: 42
  start-page: 202
  issue: 1
  year: 2019
  ident: 9657_CR83
  publication-title: Oncol Rep
– volume: 8
  start-page: 47121
  issue: 29
  year: 2017
  ident: 9657_CR190
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.17004
– volume: 37
  start-page: 15087
  issue: 11
  year: 2016
  ident: 9657_CR33
  publication-title: Tumour Biol J Int Soc Oncodev Biol Med Netherlands
  doi: 10.1007/s13277-016-5356-8
– volume: 19
  start-page: 2394
  issue: 7
  year: 2012
  ident: 9657_CR132
  publication-title: Ann Surg Oncol
  doi: 10.1245/s10434-012-2252-3
– volume: 6
  start-page: 7657
  issue: 10
  year: 2015
  ident: 9657_CR143
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.3150
– volume: 30
  start-page: 155
  issue: 2
  year: 2013
  ident: 9657_CR163
  publication-title: Clin Exp Metastasis
  doi: 10.1007/s10585-012-9524-y
– volume: 4
  start-page: 24
  year: 2018
  ident: 9657_CR105
  publication-title: Chinese Neurosurg J
  doi: 10.1186/s41016-018-0132-9
– volume: 15
  start-page: 55
  issue: 1
  year: 2015
  ident: 9657_CR159
  publication-title: Clin Exp Med
  doi: 10.1007/s10238-014-0276-7
– volume: 9
  start-page: 73
  year: 2017
  ident: 9657_CR138
  publication-title: Clin Epigenetics
  doi: 10.1186/s13148-017-0373-z
– volume: 20
  start-page: 69
  issue: 2
  year: 2019
  ident: 9657_CR36
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/s41580-018-0080-4
– volume: 12
  start-page: S2588
  year: 2020
  ident: 9657_CR198
  publication-title: Eur Urol Oncol
– volume: 19
  start-page: 108
  issue: 1
  year: 2018
  ident: 9657_CR174
  publication-title: Genome Biol
  doi: 10.1186/s13059-018-1492-3
– volume: 25
  start-page: 711
  year: 2019
  ident: 9657_CR98
  publication-title: Med Sci Monit Int Med J Exp Clin Res
– volume: 11
  start-page: 528
  issue: 4
  year: 2019
  ident: 9657_CR99
  publication-title: Cancers (basel).
  doi: 10.3390/cancers11040528
– volume: 10
  start-page: 91
  year: 2012
  ident: 9657_CR15
  publication-title: J Transl Med
  doi: 10.1186/1479-5876-10-91
– volume: 26
  start-page: 1
  issue: 8
  year: 2020
  ident: 9657_CR35
  publication-title: Cancer
– volume: 62
  start-page: 673
  issue: 11–12
  year: 2018
  ident: 9657_CR48
  publication-title: Int J Dev Biol
  doi: 10.1387/ijdb.180162sg
– volume: 7
  start-page: 339
  issue: 3
  year: 2017
  ident: 9657_CR116
  publication-title: Adv Pharm Bull
  doi: 10.15171/apb.2017.041
– volume: 2
  start-page: 213
  issue: 3
  year: 2006
  ident: 9657_CR130
  publication-title: Vasc Health Risk Manag
  doi: 10.2147/vhrm.2006.2.3.213
– volume: 12
  start-page: 19375
  issue: 19
  year: 2020
  ident: 9657_CR141
  publication-title: Aging
  doi: 10.18632/aging.103824
– volume: 149
  start-page: 2219
  issue: 5
  year: 2008
  ident: 9657_CR125
  publication-title: Endocrinology
  doi: 10.1210/en.2007-1320
– volume: 51
  start-page: 450
  issue: 9
  year: 2018
  ident: 9657_CR211
  publication-title: BMB Rep.
  doi: 10.5483/BMBRep.2018.51.9.020
– volume: 11
  start-page: 2063
  year: 2018
  ident: 9657_CR201
  publication-title: Onco Targets Ther
  doi: 10.2147/OTT.S161109
– volume: 34
  start-page: 1681
  issue: 4
  year: 2015
  ident: 9657_CR210
  publication-title: Oncol Rep
  doi: 10.3892/or.2015.4194
– volume: 33
  start-page: e22873
  issue: 5
  year: 2019
  ident: 9657_CR231
  publication-title: J Clin Lab Anal
  doi: 10.1002/jcla.22873
– volume: 8
  start-page: 1360
  issue: 11
  year: 2019
  ident: 9657_CR58
  publication-title: Cells
  doi: 10.3390/cells8111360
– volume: 11
  start-page: 420
  issue: 6
  year: 2020
  ident: 9657_CR113
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-020-2629-3
– volume: 366
  start-page: 141
  issue: 2
  year: 2012
  ident: 9657_CR38
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1110000
– volume: 1856
  start-page: 151
  issue: 1
  year: 2015
  ident: 9657_CR10
  publication-title: Biochim Biophys Acta
– volume: 14
  start-page: 137
  issue: 2
  year: 2017
  ident: 9657_CR24
  publication-title: Cancer Genomics Proteomics
  doi: 10.21873/cgp.20026
– volume: 5
  start-page: 28
  issue: 1
  year: 2020
  ident: 9657_CR39
  publication-title: Signal Transduct Target Ther
  doi: 10.1038/s41392-020-0134-x
– volume: 8
  start-page: 1247
  issue: 1
  year: 2017
  ident: 9657_CR62
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.13604
– volume: 6
  start-page: 392
  issue: 5
  year: 2020
  ident: 9657_CR171
  publication-title: Trends in Cancer
  doi: 10.1016/j.trecan.2020.02.007
– volume: 19
  start-page: 156
  issue: 2
  year: 2009
  ident: 9657_CR203
  publication-title: Cell Res
  doi: 10.1038/cr.2009.5
– volume: 35
  start-page: 15
  year: 2016
  ident: 9657_CR218
  publication-title: J Exp Clin Cancer Res
  doi: 10.1186/s13046-016-0294-2
– volume: 2018
  start-page: 3569493
  year: 2018
  ident: 9657_CR11
  publication-title: Stem Cells Int
  doi: 10.1155/2018/3569493
– volume: 62
  start-page: 837
  issue: 11–12
  year: 2018
  ident: 9657_CR92
  publication-title: Int J Dev Biol
  doi: 10.1387/ijdb.180192sz
– volume: 19
  start-page: 899
  issue: 1
  year: 2020
  ident: 9657_CR102
  publication-title: Oncol Lett
– volume: 225
  start-page: 353
  issue: 6
  year: 2015
  ident: 9657_CR1
  publication-title: Dev Genes Evol Germany
  doi: 10.1007/s00427-015-0518-z
– volume: 28
  start-page: 815
  issue: 6
  year: 2015
  ident: 9657_CR133
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2015.11.001
– volume: 54
  start-page: E72
  issue: Suppl 1
  year: 2015
  ident: 9657_CR74
  publication-title: Mol Carcinog
  doi: 10.1002/mc.22180
– volume: 24
  start-page: 1366
  issue: 9
  year: 2015
  ident: 9657_CR9
  publication-title: Cancer Epidemiol Biomarkers Prev
  doi: 10.1158/1055-9965.EPI-15-0247
– volume: 146
  start-page: 1993
  issue: 8
  year: 2020
  ident: 9657_CR29
  publication-title: J Cancer Res Clin Oncol.
  doi: 10.1007/s00432-020-03259-x
– volume: 39
  start-page: 1004
  issue: 5
  year: 2020
  ident: 9657_CR216
  publication-title: Oncogene
  doi: 10.1038/s41388-019-1013-1
– volume: 10
  start-page: 1703
  issue: 6
  year: 2018
  ident: 9657_CR205
  publication-title: Am J Transl Res
– volume: 36
  start-page: 3521
  issue: 5
  year: 2015
  ident: 9657_CR222
  publication-title: Tumour Biol
  doi: 10.1007/s13277-014-2988-4
– volume: 25
  start-page: 527
  issue: 3
  year: 2011
  ident: 9657_CR173
  publication-title: Leukemia
  doi: 10.1038/leu.2010.270
– volume: 149
  start-page: 155
  issue: 1
  year: 2018
  ident: 9657_CR120
  publication-title: Gynecol
– volume: 19
  start-page: 3
  year: 2019
  ident: 9657_CR191
  publication-title: Cancer Cell Int
  doi: 10.1186/s12935-018-0717-6
– volume: 10
  start-page: 3833
  issue: 8
  year: 2020
  ident: 9657_CR32
  publication-title: Theranostics
  doi: 10.7150/thno.41712
– volume: 11
  start-page: 512
  issue: 4
  year: 2019
  ident: 9657_CR170
  publication-title: Cancers (basel).
  doi: 10.3390/cancers11040512
– volume: 65
  start-page: 190
  issue: 8
  year: 2019
  ident: 9657_CR69
  publication-title: Clin Lab.
– volume: 30
  start-page: 863
  issue: 6
  year: 2016
  ident: 9657_CR204
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2016.10.019
– volume: 11
  start-page: 701
  issue: 6
  year: 2015
  ident: 9657_CR89
  publication-title: Int J Biol Sci
  doi: 10.7150/ijbs.11431
– volume: 53
  start-page: 49
  issue: 1
  year: 2014
  ident: 9657_CR217
  publication-title: Mol Carcinog
  doi: 10.1002/mc.21947
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Snippet Homeobox ( HOX ) genes encode highly conserved homeotic transcription factors that play a crucial role in organogenesis and tissue homeostasis. Their...
Homeobox (HOX) genes encode highly conserved homeotic transcription factors that play a crucial role in organogenesis and tissue homeostasis. Their...
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SubjectTerms Biochemistry
Biomarkers
Biomedical and Life Sciences
Cancer
Carcinogenesis - genetics
Cell Biology
Cell Transformation, Neoplastic - genetics
Deregulation
Gene expression
Genes
Genes, Homeobox - genetics
Homeobox
Homeostasis
HOX gene
Humans
Life Sciences
Medical diagnosis
Metastases
Neoplasms - metabolism
Organogenesis
Pharmacology/Toxicology
Review
Signal transduction
Signal Transduction - genetics
Signaling
Transcription factors
Tumorigenesis
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Title Molecular implications of HOX genes targeting multiple signaling pathways in cancer
URI https://link.springer.com/article/10.1007/s10565-021-09657-2
https://www.ncbi.nlm.nih.gov/pubmed/34617205
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Volume 38
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