Experimental Modeling of Proliferative Vitreoretinopathy. An Experimental Morphological Study

• Published in: Bulletin of experimental biology and medicine Vol. 159; no. 1; pp. 100 - 102
• Main Authors: Khoroshilova-Maslova, I. P., Leparskaya, N. L., Nabieva, M. M., Andreeva, L. D.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2015; Springer; Springer Nature B.V
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Blood Platelets; Cell Biology; Cell Movement; Disease Models, Animal; Epiretinal Membrane - pathology; Interleukin-1beta - pharmacology; Internal Medicine; Laboratory Medicine; Optic Nerve - pathology; Pathology; Rabbits; Recombinant Proteins - pharmacology; Retinal Detachment - pathology; Retinal Pigment Epithelium - cytology; Retinal Pigment Epithelium - pathology; Uvea - pathology; Vitreoretinopathy, Proliferative - pathology; Vitreous Body - pathology
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-015-2900-2

A model of proliferative vitreoretinopathy induced by simultaneous intravitreal injection of recombinant IL-1β and platelet concentrate is created and its main morphological manifestations are studied on Chinchilla rabbits. The model reflects pathogenesis of proliferative vitreoretinopathy: epiretinal membrane with the formation of retinal plication, traction detachment of the retina; moderate inflammatory reaction in the uveal tract, in the optic nerve infundibulum, in the vitreous body; intact structural elements of the retina, dissociation of the retinal pigmented epithelium cells with their subsequent migration. The model is adequate to the clinical picture of proliferative vitreoretinopathy in humans, which recommends it for experimental studies of the efficiency of drug therapy and prevention of this disease.