Significantly increased low shear rate viscosity, blood elastic modulus, and RBC aggregation in adults following cardiac surgery

• Published in: Scientific reports Vol. 8; no. 1; pp. 7173 - 10
• Main Authors: Wu, Yi-Fan, Hsu, Po-Shun, Tsai, Chien-Sung, Pan, Pin-Cheng, Chen, Yeng-Long
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.05.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 14/63; 631/57; 639/166/985; 692/4019/2776; Blood; Coronary artery disease; Erythrocytes; Fibrinogen; Heart diseases; Heart surgery; Hematocrit; Humanities and Social Sciences; Inflammation; Ischemia; Mechanical properties; multidisciplinary; Patients; Rheumatic heart disease; Science; Science (multidisciplinary); Viscoelasticity; Viscosity
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-018-25317-8

Open heart surgeries are common for treating ischemic and heart valve disease. During cardiac surgery, cardiopulmonary bypass (CPB) can temporarily take over the function of heart and lungs. However, elevated red blood cell (RBC) aggregation may lead to the common side-effects such as microinfarction. We investigated blood physical properties changes and the correlation between blood microstructure, viscoelastic response and biochemical changes following surgery with CPB. We examined shear-rate dependent blood viscosity, elasticity and RBC aggregate size in the pre-surgery disease state, post-surgery state and long-term recovery state of cardiac surgical patients. Within a week following surgery, the patient hematocrit was significantly lower due to CPB. Despite lower RBC concentration, the RBC aggregate shape became larger and more rounded, which is correlated to the elevated plasma fibrinogen related to systemic inflammatory response. During the same period, the hematocrit-adjusted low shear rate viscosity increased significantly, as did the yield stress, indicating more solid-like behavior for blood. Six months to one year later, all the physical and biochemical properties measured returned to baseline.