Carbon-based ruthenium nanomaterial-based electroanalytical sensors for the detection of anticancer drug Idarubicin

• Published in: Scientific reports Vol. 10; no. 1; pp. 11057 - 12
• Main Authors: Kaya, S. Irem, Kurbanoglu, Sevinc, Yavuz, Ejmer, Demiroglu Mustafov, Sibel, Sen, Fatih, Ozkan, Sibel A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.07.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 639/638/11/872; 639/638/161; Antineoplastic Agents - analysis; Antineoplastic Agents - blood; Antineoplastic drugs; Antitumor agents; Biological samples; Cancer; Carbon; Carbon - chemistry; Electrochemical Techniques; Electrochemistry; Electrodes; Electrons; Humanities and Social Sciences; Humans; Hydrogen-Ion Concentration; Idarubicin - analysis; Idarubicin - blood; Limit of Detection; Metal Nanoparticles - chemistry; Metal Nanoparticles - ultrastructure; Microscopy, Electron, Transmission; multidisciplinary; Nanomaterials; Nanoparticles; Nanostructures - chemistry; Nanostructures - ultrastructure; Nanotechnology; Particle Size; Photoelectron Spectroscopy; Ruthenium; Ruthenium - chemistry; Science; Science (multidisciplinary); Spectroscopy; Spectrum analysis; Transmission electron microscopy; X-Ray Diffraction
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-68055-6

In this work, a novel nanosensing platform was suggested based on ruthenium for the sensitive determination of Idarubicin anticancer drugs. Ruthenium/Vulcan carbon-based nanoparticles were synthesized ultrasonication method and then characterized by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD). The mean particle size of the nanoparticles calculated by the TEM analysis was found to be 1.98 nm ± 0.29 nm, and the Ru nanoparticles were mostly dispersed on the support material. Glassy carbon electrode (GCE) surface was modified with Ruthenium/Vulcan carbon-based nanomaterials (Ru@VC), and characterization of the nanosensor was performed using electrochemical impedance spectroscopy and cyclic voltammetry. The limit of detection (LOD) and limit of quantification (LOQ) values were found as 9.25 × 10 –9  M and 2.8 × 10 –8  M in buffer samples. To demonstrate the applicability and validity of developed nanosensor, it was used for the determination of Idarubicin in Idamen ® IV (10 mg/10 mL vial) and human serum sample. The results of recovery studies showed that the Ru@VC/GCE nanosensor was free from excipient interferences in the dosage forms of injection, and it can be successfully applied to biological samples.