Impact on Health-Related Quality of Life of Video-Assisted Thoracoscopic Surgery for Lung Cancer

• Published in: Annals of surgical oncology Vol. 27; no. 4; pp. 1259 - 1271
• Main Authors: Avery, Kerry N. L., Blazeby, Jane M., Chalmers, Katy A., Batchelor, Timothy J. P., Casali, Gianluca, Internullo, Eveline, Krishnadas, Rakesh, Evans, Clare, West, Doug
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.04.2020; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Appetite loss; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - surgery; Constipation; Dyspnea; Fatigue; Fatigue - etiology; Female; Humans; Lung cancer; Lung Neoplasms - pathology; Lung Neoplasms - surgery; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Staging; Non-small cell lung carcinoma; Oncology; Pain, Postoperative - etiology; Patients; Prospective Studies; Quality of Life; Respiration; Small cell lung carcinoma; Statistical analysis; Surgery; Surgical Oncology; Surveys and Questionnaires; Thoracic Oncology; Thoracic Surgery, Video-Assisted; Thoracotomy - adverse effects; United Kingdom; United Kingdom
• ISSN: 1068-9265; 1534-4681
• DOI: 10.1245/s10434-019-08090-4

Background Video-assisted thoracoscopic surgery (VATS) approaches are increasingly used in lung cancer surgery, but little is known about their impact on patients’ health-related quality of life (HRQL). This prospective study measured recovery and HRQL in the year after VATS for non-small cell lung cancer (NSCLC) and explored the feasibility of HRQL data collection in patients undergoing VATS or open lung resection. Patients and Methods Consecutive patients referred for surgical assessment (VATS or open surgery) for proven/suspected NSCLC completed HRQL and fatigue assessments before and 1, 3, 6 and 12 months post-surgery. Mean HRQL scores were calculated for patients who underwent VATS (segmental, wedge or lobectomy resection). Paired t -tests compared mean HRQL between baseline and expected worst (1 month), early (3 months) and longer-term (12 months) recovery time points. Results A total of 92 patients received VATS, and 18 open surgery. Questionnaire response rates were high (pre-surgery 96–100%; follow-up 67–85%). Pre-surgery, VATS patients reported mostly high (good) functional health scores [(European Organisation for Research and Treatment of Cancer) EORTC function scores > 80] and low (mild) symptom scores (EORTC symptom scores < 20). One-month post-surgery, patients reported clinically and statistically significant deterioration in overall health and physical, role and social function (19–36 points), and increased fatigue, pain, dyspnoea, appetite loss and constipation [EORTC 12–26; multidimensional fatigue inventory (MFI-20) 3–5]. HRQL had not fully recovered 12 months post-surgery, with reduced physical, role and social function (10–14) and persistent fatigue and dyspnoea (EORTC 12–22; MFI-20 2.7–3.2). Conclusions Lung resection has a considerable detrimental impact on patients’ HRQL that is not fully resolved 12 months post-surgery, despite a VATS approach. Graphic Abstract