Assessment of total and regional bone mineral density using bioelectrical impedance vector analysis in elderly population

• Published in: Scientific reports Vol. 11; no. 1; pp. 21161 - 8
• Main Authors: Lu, Hsueh-Kuan, Lai, Chung-Liang, Lee, Li-Wen, Chu, Lee-Ping, Hsieh, Kuen-Chang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.10.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308; 692/53/2423; Absorptiometry, Photon - methods; Aged; Aged, 80 and over; Aging - pathology; Algorithms; Bone Density; Bone mineral density; Dual energy X-ray absorptiometry; Electric Impedance; Female; Femur; Femur Neck - diagnostic imaging; Femur Neck - growth & development; Humanities and Social Sciences; Humans; Male; Middle Aged; multidisciplinary; Older people; Osteoporosis - epidemiology; Population studies; Science; Science (multidisciplinary); Spine
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-00575-1

This study aimed to investigate the relationship between bone mineral density (BMD) and height-adjusted resistance (R/H), reactance (Xc/H) and phase angle (PhA). A total of 61 male and 64 female subjects aged over 60 years were recruited from middle Taiwan. The R and Xc were measured using Bodystat Quadscan 4000 at a frequency of 50 kHz. BMD at the whole body, L2–L4 spine, and dual femur neck (DFN), denoted as BMD Total , BMD L2–L4, and BMD DFN , were calculated using a Hologic DXA scanner. The R-Xc graph was used to assess vector shift among different levels of BMD. BMD was positively correlated with Xc/H and negatively correlated with R/H ( p  < 0.001). The General Linear Model (GLM) regression results were as follows: BMD Total  = 1.473–0.002 R/H + 0.007 Xc/H, r  = 0.684; BMD L2–L4  = 1.526–0.002 R/H + 0.012 Xc/H, r  = 0.655; BMD DFN  = 1.304–0.002 R/H + Xc/H, r  = 0.680; p  < 0.0001. Distribution of vector in the R-Xc graph was significantly different for different levels of BMD Total , BMD L2–L4 and BMD DFN . R/H and Xc/H were correlated with BMD in the elderly. The linear combination of R/H and Xc/H can effectively predict the BMD of the whole body, spine and proximal femur, indicating that BIVA may be used in clinical and home-use monitoring tool for screening BMD in the elderly in the future.