Pharmacological Activities of Schiff Bases and Their Derivatives with Low and High Molecular Phosphonates

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 16; no. 7; p. 938
• Main Authors: Tsacheva, Ivelina, Todorova, Zornica, Momekova, Denitsa, Momekov, Georgi, Koseva, Neli
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.06.2023; MDPI
• Subjects: aminophophonates; anthracene-containing schiff bases; Anti-infective agents; Antimicrobial agents; Antimitotic agents; Antineoplastic agents; Antioxidants; Biological activity; Cancer; Chemical properties; Chemistry; Drugs; E coli; furan-containing Schiff bases; Furans; Health aspects; Ligands; Pharmaceuticals; pharmacological activities; Pharmacology, Experimental; Phosphonates; poly(aminophosphonate)s; Review; Schiff bases; Streptococcus infections; Bulgaria; pharmacological activities; furan-containing Schiff bases; poly(aminophosphonate)s; anthracene-containing schiff bases; aminophophonates
• ISSN: 1424-8247; 1424-8247
• DOI: 10.3390/ph16070938

This review paper is focused on the design of anthracene and furan-containing Schiff bases and their advanced properties as ligands in complex transition metal ions The paper also provides a brief overview on a variety of biological applications, namely, potent candidates with antibacterial and antifungal activity, antioxidant and chemosensing properties. These advantageous properties are enhanced upon metal complexing. The subject of the review has been extended with a brief discussion on reactivity of Schiff bases with hydrogen phosphonates and the preparation of low and high molecular phosphonates, as well as their application as pharmacological agents. This work will be of interest for scientists seeking new challenges in discovering advanced pharmacological active molecules gaining inspiration from the versatile families of imines and aminophosphonates.