Age-Related Features of Cardiomyocyte Ploidy in Patients with Hypertrophic Obstructive Cardiomyopathy

Endomyocardial biopsy samples of the interventricular septum from patients with hypertrophic cardiomyopathy isolated during myectomy were examined. We revealed significant variability of cardiomyocyte ploidy (from 2.9c to 13.5c) that directly correlated with myocyte size; the maximum ploidy was foun...

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Published inBulletin of experimental biology and medicine Vol. 159; no. 1; pp. 95 - 99
Main Authors Sukhacheva, T. V., Chudinovskikh, Yu. A., Eremeeva, M. V., Serov, R. A.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.05.2015
Springer
Springer Nature B.V
Subjects
Adolescent
Adult
Age Factors
Aging
Biomedical and Life Sciences
Biomedicine
Biopsy
Cardiomyopathy, Hypertrophic - pathology
Care and treatment
Cell Biology
DNA - genetics
Genetic aspects
Humans
Internal Medicine
Laboratory Medicine
Middle Aged
Muscle proteins
Myocardial diseases
Myocardium - pathology
Myocytes, Cardiac - cytology
Myocytes, Cardiac - pathology
Myosin
Pathology
Ploidies
Ventricular Septum - pathology
Young Adult
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Summary:Endomyocardial biopsy samples of the interventricular septum from patients with hypertrophic cardiomyopathy isolated during myectomy were examined. We revealed significant variability of cardiomyocyte ploidy (from 2.9c to 13.5c) that directly correlated with myocyte size; the maximum ploidy was found in young patients. Ultrastructural signs of increased contractile and synthetic activity of cells were observed in patients with high DNA content in cardiomyocytes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-015-2899-4