Targeting ferroptosis as a vulnerability in pulmonary diseases

• Published in: Cell death & disease Vol. 13; no. 7; pp. 649 - 14
• Main Authors: Yang, Li, Cao, Li-mian, Zhang, Xiao-ju, Chu, Bo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.07.2022; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/95; 38/39; 631/80/82; 692/699/1785; Antibiotic resistance; Antibodies; Antigens; Apoptosis; Asthma; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Cell death; Chronic obstructive pulmonary disease; Critical care; Drug resistance; Enzymes; Fatty acids; Fatty Acids, Unsaturated - metabolism; Ferroptosis; Free radicals; Hemoglobin; Homeostasis; Hospitals; Humans; Immunology; Iron; Life Sciences; Lipid Peroxidation; Lipids; Lung cancer; Lung Diseases; Metabolism; Oxidation-Reduction; Oxidative stress; Phospholipids; Phospholipids - metabolism; Polyunsaturated fatty acids; Regulation; Review; Review Article

Ferroptosis is an iron-dependent regulated cell death marked by excessive oxidative phospholipids (PLs). The polyunsaturated fatty acids-containing phospholipids (PUFA-PLs) are highly susceptible to lipid peroxidation under oxidative stress. Numerous pulmonary diseases occurrences and degenerative p...