Targeting ferroptosis as a vulnerability in pulmonary diseases

• Published in: Cell death & disease Vol. 13; no. 7; pp. 649 - 14
• Main Authors: Yang, Li, Cao, Li-mian, Zhang, Xiao-ju, Chu, Bo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.07.2022; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/95; 38/39; 631/80/82; 692/699/1785; Antibiotic resistance; Antibodies; Antigens; Apoptosis; Asthma; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Cell death; Chronic obstructive pulmonary disease; Critical care; Drug resistance; Enzymes; Fatty acids; Fatty Acids, Unsaturated - metabolism; Ferroptosis; Free radicals; Hemoglobin; Homeostasis; Hospitals; Humans; Immunology; Iron; Life Sciences; Lipid Peroxidation; Lipids; Lung cancer; Lung Diseases; Metabolism; Oxidation-Reduction; Oxidative stress; Phospholipids; Phospholipids - metabolism; Polyunsaturated fatty acids; Regulation; Review; Review Article
• ISSN: 2041-4889; 2041-4889
• DOI: 10.1038/s41419-022-05070-7

Ferroptosis is an iron-dependent regulated cell death marked by excessive oxidative phospholipids (PLs). The polyunsaturated fatty acids-containing phospholipids (PUFA-PLs) are highly susceptible to lipid peroxidation under oxidative stress. Numerous pulmonary diseases occurrences and degenerative pathologies are driven by ferroptosis. This review discusses the role of ferroptosis in the pathogenesis of pulmonary diseases including asthma, lung injury, lung cancer, fibrotic lung diseases, and pulmonary infection. Additionally, it is proposed that targeting ferroptosis is a potential treatment for pulmonary diseases, particularly drug-resistant lung cancer or antibiotic-resistant pulmonary infection, and reduces treatment-related adverse events.