Targeting ferroptosis as a vulnerability in pulmonary diseases

Ferroptosis is an iron-dependent regulated cell death marked by excessive oxidative phospholipids (PLs). The polyunsaturated fatty acids-containing phospholipids (PUFA-PLs) are highly susceptible to lipid peroxidation under oxidative stress. Numerous pulmonary diseases occurrences and degenerative p...

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Published inCell death & disease Vol. 13; no. 7; pp. 649 - 14
Main Authors Yang, Li, Cao, Li-mian, Zhang, Xiao-ju, Chu, Bo
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 26.07.2022
Springer Nature B.V
Nature Publishing Group
Subjects
13/95
38/39
631/80/82
692/699/1785
Antibiotic resistance
Antibodies
Antigens
Apoptosis
Asthma
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cell Culture
Cell death
Chronic obstructive pulmonary disease
Critical care
Drug resistance
Enzymes
Fatty acids
Fatty Acids, Unsaturated - metabolism
Ferroptosis
Free radicals
Hemoglobin
Homeostasis
Hospitals
Humans
Immunology
Iron
Life Sciences
Lipid Peroxidation
Lipids
Lung cancer
Lung Diseases
Metabolism
Oxidation-Reduction
Oxidative stress
Phospholipids
Phospholipids - metabolism
Polyunsaturated fatty acids
Regulation
Review
Review Article
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Abstract Ferroptosis is an iron-dependent regulated cell death marked by excessive oxidative phospholipids (PLs). The polyunsaturated fatty acids-containing phospholipids (PUFA-PLs) are highly susceptible to lipid peroxidation under oxidative stress. Numerous pulmonary diseases occurrences and degenerative pathologies are driven by ferroptosis. This review discusses the role of ferroptosis in the pathogenesis of pulmonary diseases including asthma, lung injury, lung cancer, fibrotic lung diseases, and pulmonary infection. Additionally, it is proposed that targeting ferroptosis is a potential treatment for pulmonary diseases, particularly drug-resistant lung cancer or antibiotic-resistant pulmonary infection, and reduces treatment-related adverse events.
AbstractList Ferroptosis is an iron-dependent regulated cell death marked by excessive oxidative phospholipids (PLs). The polyunsaturated fatty acids-containing phospholipids (PUFA-PLs) are highly susceptible to lipid peroxidation under oxidative stress. Numerous pulmonary diseases occurrences and degenerative pathologies are driven by ferroptosis. This review discusses the role of ferroptosis in the pathogenesis of pulmonary diseases including asthma, lung injury, lung cancer, fibrotic lung diseases, and pulmonary infection. Additionally, it is proposed that targeting ferroptosis is a potential treatment for pulmonary diseases, particularly drug-resistant lung cancer or antibiotic-resistant pulmonary infection, and reduces treatment-related adverse events.Ferroptosis is an iron-dependent regulated cell death marked by excessive oxidative phospholipids (PLs). The polyunsaturated fatty acids-containing phospholipids (PUFA-PLs) are highly susceptible to lipid peroxidation under oxidative stress. Numerous pulmonary diseases occurrences and degenerative pathologies are driven by ferroptosis. This review discusses the role of ferroptosis in the pathogenesis of pulmonary diseases including asthma, lung injury, lung cancer, fibrotic lung diseases, and pulmonary infection. Additionally, it is proposed that targeting ferroptosis is a potential treatment for pulmonary diseases, particularly drug-resistant lung cancer or antibiotic-resistant pulmonary infection, and reduces treatment-related adverse events.
Abstract Ferroptosis is an iron-dependent regulated cell death marked by excessive oxidative phospholipids (PLs). The polyunsaturated fatty acids-containing phospholipids (PUFA-PLs) are highly susceptible to lipid peroxidation under oxidative stress. Numerous pulmonary diseases occurrences and degenerative pathologies are driven by ferroptosis. This review discusses the role of ferroptosis in the pathogenesis of pulmonary diseases including asthma, lung injury, lung cancer, fibrotic lung diseases, and pulmonary infection. Additionally, it is proposed that targeting ferroptosis is a potential treatment for pulmonary diseases, particularly drug-resistant lung cancer or antibiotic-resistant pulmonary infection, and reduces treatment-related adverse events.
Ferroptosis is an iron-dependent regulated cell death marked by excessive oxidative phospholipids (PLs). The polyunsaturated fatty acids-containing phospholipids (PUFA-PLs) are highly susceptible to lipid peroxidation under oxidative stress. Numerous pulmonary diseases occurrences and degenerative pathologies are driven by ferroptosis. This review discusses the role of ferroptosis in the pathogenesis of pulmonary diseases including asthma, lung injury, lung cancer, fibrotic lung diseases, and pulmonary infection. Additionally, it is proposed that targeting ferroptosis is a potential treatment for pulmonary diseases, particularly drug-resistant lung cancer or antibiotic-resistant pulmonary infection, and reduces treatment-related adverse events.
ArticleNumber 649
Author Yang, Li
Zhang, Xiao-ju
Cao, Li-mian
Chu, Bo
Author_xml – sequence: 1
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  orcidid: 0000-0003-0754-7941
  surname: Yang
  fullname: Yang, Li
  organization: Department of Respiratory and Critical Care Medicine, Zhengzhou University People’s Hospital, Henan Provincial People’s Hospital
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  givenname: Li-mian
  surname: Cao
  fullname: Cao, Li-mian
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  organization: Department of Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University
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  givenname: Xiao-ju
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  surname: Zhang
  fullname: Zhang, Xiao-ju
  email: zhangxiaoju@zzu.edu.cn
  organization: Department of Respiratory and Critical Care Medicine, Zhengzhou University People’s Hospital, Henan Provincial People’s Hospital
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  givenname: Bo
  orcidid: 0000-0001-9754-2743
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  fullname: Chu, Bo
  email: chubo123@sdu.edu.cn
  organization: Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University
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OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1038/s41419-022-05070-7
PMID 35882850
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crossref_primary_10_1038_s41419_022_05070_7
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ProviderPackageCode CITATION
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PublicationCentury 2000
PublicationDate 2022-07-26
PublicationDateYYYYMMDD 2022-07-26
PublicationDate_xml – month: 07
  year: 2022
  text: 2022-07-26
  day: 26
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Cell death & disease
PublicationTitleAbbrev Cell Death Dis
PublicationTitleAlternate Cell Death Dis
PublicationYear 2022
Publisher Nature Publishing Group UK
Springer Nature B.V
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Springer Nature B.V
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Snippet Ferroptosis is an iron-dependent regulated cell death marked by excessive oxidative phospholipids (PLs). The polyunsaturated fatty acids-containing...
Abstract Ferroptosis is an iron-dependent regulated cell death marked by excessive oxidative phospholipids (PLs). The polyunsaturated fatty acids-containing...
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SubjectTerms 13/95
38/39
631/80/82
692/699/1785
Antibiotic resistance
Antibodies
Antigens
Apoptosis
Asthma
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cell Culture
Cell death
Chronic obstructive pulmonary disease
Critical care
Drug resistance
Enzymes
Fatty acids
Fatty Acids, Unsaturated - metabolism
Ferroptosis
Free radicals
Hemoglobin
Homeostasis
Hospitals
Humans
Immunology
Iron
Life Sciences
Lipid Peroxidation
Lipids
Lung cancer
Lung Diseases
Metabolism
Oxidation-Reduction
Oxidative stress
Phospholipids
Phospholipids - metabolism
Polyunsaturated fatty acids
Regulation
Review
Review Article
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Title Targeting ferroptosis as a vulnerability in pulmonary diseases
URI https://link.springer.com/article/10.1038/s41419-022-05070-7
https://www.ncbi.nlm.nih.gov/pubmed/35882850
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Volume 13
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