Synthesis of Some CC Chemokines and Their Receptors in the Synovium in Rheumatoid Arthritis

• Published in: Bulletin of experimental biology and medicine Vol. 158; no. 2; pp. 192 - 196
• Main Authors: Zhebrun, D. A., Totolyan, Areg A., Maslyanskii, A. L., Titov, A. G., Patrukhin, A. P., Kostareva, A. A., Gol’tseva, I. S.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.12.2014; Springer; Springer Nature B.V
• Subjects: Adult; Arthritis; Arthritis, Rheumatoid - metabolism; B cells; Biomedical and Life Sciences; Biomedicine; Cell Biology; Chemokines, CC - biosynthesis; Chemokines, CC - metabolism; Development and progression; Female; Humans; Internal Medicine; Laboratory Medicine; Male; Middle Aged; Nephelometry and Turbidimetry; Osteoarthritis - metabolism; Pathology; Receptors, CCR - biosynthesis; Receptors, CCR - metabolism; Rheumatoid factor; RNA; RNA, Messenger - metabolism; Statistics, Nonparametric; Synovial Membrane - metabolism; expression; synovium; chemokines; rheumatoid arthritis; angiogenesis
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-014-2720-9

We studied the expression of some CC chemokines and their receptors in the synovium of patients with rheumatoid arthritis, osteoarthrosis, and a history of joint injury. In patients with rheumatoid arthritis, the levels mRNA for some angiogenic and proinflammatory chemokines (CCL5/RANTES, CCL11/eotaxin, CCL24/eotaxin-2, and CCL26/eotaxin-3) and their receptors (CCR1, CCR2, CCR3, CCR4, and CCR5) was elevated. mRNA expression correlated with activity, stage, and serological status of rheumatoid arthritis. Obtained data confirm the importance of CC chemokines as mediators of angiogenesis and inflammation in the synovium in rheumatoid arthritis.