Immunosuppressive Sesquiterpenes from Tripterygium wilfordii

• Published in: Chemical & pharmaceutical bulletin Vol. 53; no. 6; pp. 607 - 610
• Main Authors: Wang, Xiaodong, Gao, Wenyuan, Yao, Zhi, Zhang, Shaoyu, Zhang, Yanwen, Takaishi, Yoshihisa, Duan, Hongquan
• Format: Journal Article
• Language: English
• Published: TOKYO The Pharmaceutical Society of Japan 01.06.2005; Pharmaceutical Soc Japan; Japan Science and Technology Agency
• Subjects: Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - isolation & purification; Drugs, Chinese Herbal - pharmacology; immunosuppressive activity; Immunosuppressive Agents - chemistry; Immunosuppressive Agents - isolation & purification; Immunosuppressive Agents - pharmacology; Life Sciences & Biomedicine; Lymphocytes - drug effects; Lymphocytes - immunology; Pharmacology & Pharmacy; Physical Sciences; Rhizome; Science & Technology; sesquiterpene; Sesquiterpenes - chemistry; Sesquiterpenes - isolation & purification; Sesquiterpenes - pharmacology; Tripterygium; Tripterygium wilfordii; xylem; xylem; POLYOL ESTERS; VAR REGELII; Tripterygium wilfordii; sesquiterpene; immunosuppressive activity; ALKALOIDS
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.53.607

Five new sesquiterpenes, 1β-furanoyl-2β,3α,7α,8β,11-pentaacetoxy-4α,5α-dihydroxy-dihydroagarofuran (1), 1β,2β,3α,5α,7β,8β,11-heptaacetoxy-dihydroagarofuran (2), 1β-furanoyl-2β,3α,7α,8β,11-pentaacetoxy-5α-hydroxy-dihydroagarofuran (3), 1β,7β,8α-triacetoxy-2β-furanoyl-4α-hydroxy-11-isobutyryloxy-dihydroagarofuran (4), and 1β-nicotinoyl-2β,5α,7β-triacetoxy-4α-hydroxy-11-isobutyryloxy-8α-furanoyl-dihydroagarofuran (5), were isolated from the xylem of Tripterygium wilfordii, together with a known compound (6). Their structures were elucidated on the basis of spectroscopic studies. Compounds 2—5 showed significant immunosuppressive activities.