TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination

• Published in: Nature communications Vol. 11; no. 1; p. 2193
• Main Authors: Deng, Meng, Tam, Jason W., Wang, Lufei, Liang, Kaixin, Li, Sirui, Zhang, Lu, Guo, Haitao, Luo, Xiaobo, Zhang, Yang, Petrucelli, Alex, Davis, Beckley K., Conti, Brian J., June Brickey, W., Ko, Ching-Chang, Lei, Yu L., Sun, Shaocong, Ting, Jenny P. -Y.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.05.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/106; 13/109; 13/31; 13/89; 14; 14/19; 38; 38/39; 38/77; 42; 42/44; 45; 49; 631/250; 631/250/255; 631/250/262; 692/699; 692/699/255; Animals; Antiviral agents; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell Line; Cells, Cultured; Chlorocebus aethiops; Cytosol - metabolism; Cytosol - virology; Double-stranded RNA; Gene deletion; Gene Expression Regulation; HEK293 Cells; HeLa Cells; Humanities and Social Sciences; Humans; Immune system; Immunity; Inflammatory diseases; Innate immunity; Interferon; Interferon regulatory factor 3; Interferon Type I - genetics; Interferon Type I - metabolism; Jurkat Cells; Kinases; Lysine - genetics; Lysine - metabolism; Macrophages; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mitochondria; multidisciplinary; Myeloid cells; Myeloid Cells - metabolism; Myeloid Cells - virology; Nucleic acids; Pattern recognition; Pattern recognition receptors; Polyinosinic:polycytidylic acid; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - metabolism; Proteins; Receptors; Retinoic acid; Ribonucleic acid; RNA; RNA viruses; RNA, Viral - genetics; RNA, Viral - metabolism; Science; Science (multidisciplinary); Signal transduction; Signaling; Stomatitis; THP-1 Cells; Ubiquitination; Vero Cells; Vesicular stomatitis Indiana virus - genetics; Vesicular stomatitis Indiana virus - physiology; Viruses

Innate immunity to nucleic acids forms the backbone for anti-viral immunity and several inflammatory diseases. Upon sensing cytosolic viral RNA, retinoic acid-inducible gene-I-like receptors (RLRs) interact with the mitochondrial antiviral signaling protein (MAVS) and activate TANK-binding kinase 1...