Nanocurcumin and curcumin prevent N, N'-methylenebisacrylamide-induced liver damage and promotion of hepatic cancer cell growth

• Published in: Scientific reports Vol. 12; no. 1; p. 8319
• Main Authors: Atia, Mona M., Abdel-Tawab, Hanem S., Mostafa, Amna M., Mobarak, Seham A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.05.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/67; 631/80; Acrylamide; Acrylamides; Alanine; Alanine transaminase; Animals; Apoptosis; Aspartate aminotransferase; Cancer; Caspase-3; Cell viability; Collagen (type I); Contaminants; Curcumin; Curcumin - chemistry; Cytotoxicity; Fibrosis; Glycogen; Histopathology; Humanities and Social Sciences; Liver; Liver cancer; Liver Neoplasms - drug therapy; Mice; multidisciplinary; Nanoparticles; Nanoparticles - chemistry; Phytochemicals; Science; Science (multidisciplinary)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-12406-y

Acrylamide (AC) is an environmental contaminant with cancer-promoting and cytotoxic properties, while curcumin (Cur.) is a phytochemical with documented anticancer and cytoprotective efficacy. Nanoparticle formulations can increase the efficacy of phytochemicals, so we examined the anticancer and hepatoprotective efficacies of nanocurcumin (N.Cur). Curcumin and nanocurcumin reduced HepG2 and Huh-7 cancer cell viability and increased apoptosis in the presence and absence of AC, while AC alone promoted proliferation. Furthermore, the anticancer efficacy of nanocurcumin was greater than that of curcumin. In mice, AC greatly increased hepatic expression of CYP2E1, P53, cleaved caspase-3, and COL1A1 as well as serum alanine aminotransferase and aspartate aminotransferase activities. These effects were reversed by nanocurcumin and curcumin. Nanocurcumin also reduced the histopathology and fibrosis caused by AC, and reversed AC-induced glycogen depletion. Nanoparticle formulation can increase the anticancer and hepatoprotective efficiencies of curcumin.