The human microbiome and its link in prostate cancer risk and pathogenesis

There is growing evidence of the microbiome's role in human health and disease since the human microbiome project. The microbiome plays a vital role in influencing cancer risk and pathogenesis. Several studies indicate microbial pathogens to account for over 15-20% of all cancers. Furthermore,...

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Published inInfectious agents and cancer Vol. 15; no. 1; pp. 1 - 53
Main Authors Katongole, Paul, Sande, Obondo J, Joloba, Moses, Reynolds, Steven J, Niyonzima, Nixon
Format Journal Article
LanguageEnglish
Published London BioMed Central Ltd 31.08.2020
BioMed Central
BMC
Subjects
And urinary microbiome
Atrophy
Bacteria
Cancer research
Cancer therapies
Chemotherapy
Clinical trials
Deoxyribonucleic acid
Development and progression
Digestive system
DNA
DNA damage
Etiology
Genomes
Gut microbiome
Health aspects
Human papillomavirus
Immune system
Immunotherapy
Inflammation
Intestinal microflora
Microbiome
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Pathogenesis
Prostate cancer
Radiation therapy
Radiotherapy
Review
Risk factors
Tumorigenesis
Tumors
Urogenital system
Virulence
Viruses
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Summary:There is growing evidence of the microbiome's role in human health and disease since the human microbiome project. The microbiome plays a vital role in influencing cancer risk and pathogenesis. Several studies indicate microbial pathogens to account for over 15-20% of all cancers. Furthermore, the interaction of the microbiota, especially the gut microbiota in influencing response to chemotherapy, immunotherapy, and radiotherapy remains an area of active research. Certain microbial species have been linked to the improved clinical outcome when on different cancer therapies. The recent discovery of the urinary microbiome has enabled the study to understand its connection to genitourinary malignancies, especially prostate cancer. Prostate cancer is the second most common cancer in males worldwide. Therefore research into understanding the factors and mechanisms associated with prostate cancer etiology, pathogenesis, and disease progression is of utmost importance. In this review, we explore the current literature concerning the link between the gut and urinary microbiome and prostate cancer risk and pathogenesis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1750-9378
1750-9378
DOI:10.1186/s13027-020-00319-2