Implementation of Whole-Body MRI (MY-RADS) within the OPTIMUM/MUKnine multi-centre clinical trial for patients with myeloma

• Published in: Insights into imaging Vol. 13; no. 1; p. 123
• Main Authors: Rata, Mihaela, Blackledge, Matthew, Scurr, Erica, Winfield, Jessica, Koh, Dow-Mu, Dragan, Alina, Candito, Antonio, King, Alexander, Rennie, Winston, Gaba, Suchi, Suresh, Priya, Malcolm, Paul, Davis, Amy, Nilak, Anjumara, Shah, Aarti, Gandhi, Sanjay, Albrizio, Mauro, Drury, Arnold, Roberts, Sadie, Jenner, Matthew, Brown, Sarah, Kaiser, Martin, Messiou, Christina
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 28.07.2022; Springer Nature B.V; SpringerOpen
• Subjects: Bone marrow; Clinical trials; Data acquisition; Data transfer (computers); Diagnostic Radiology; DWI; Health services; Image quality; Imaging; Internal Medicine; Interventional Radiology; Magnetic resonance imaging; Medical imaging; Medicine; Medicine & Public Health; Multi-centre clinical trial; Multiple myeloma; Myeloma; Neuroradiology; Optimization; Original; Original Article; Qualitative analysis; Quality assurance; Quantitative analysis; Radiology; Scanners; T1-w Dixon; Ultrasound; Whole-body MRI; Myeloma; Whole-body MRI; T1-w Dixon; DWI; Multi-centre clinical trial
• ISSN: 1869-4101; 1869-4101
• DOI: 10.1186/s13244-022-01253-0

Background Whole-body (WB) MRI, which includes diffusion-weighted imaging (DWI) and T 1 -w Dixon, permits sensitive detection of marrow disease in addition to qualitative and quantitative measurements of disease and response to treatment of bone marrow. We report on the first study to embed standardised WB-MRI within a prospective, multi-centre myeloma clinical trial (IMAGIMM trial, sub-study of OPTIMUM/MUKnine) to explore the use of WB-MRI to detect minimal residual disease after treatment. Methods The standardised MY-RADS WB-MRI protocol was set up on a local 1.5 T scanner. An imaging manual describing the MR protocol, quality assurance/control procedures and data transfer was produced and provided to sites. For non-identical scanners (different vendor or magnet strength), site visits from our physics team were organised to support protocol optimisation. The site qualification process included review of phantom and volunteer data acquired at each site and a teleconference to brief the multidisciplinary team. Image quality of initial patients at each site was assessed. Results WB-MRI was successfully set up at 12 UK sites involving 3 vendor systems and two field strengths. Four main protocols (1.5 T Siemens, 3 T Siemens, 1.5 T Philips and 3 T GE scanners) were generated. Scanner limitations (hardware and software) and scanning time constraint required protocol modifications for 4 sites. Nevertheless, shared methodology and imaging protocols enabled other centres to obtain images suitable for qualitative and quantitative analysis. Conclusions Standardised WB-MRI protocols can be implemented and supported in prospective multi-centre clinical trials. Trial registration NCT 03188172 clinicaltrials.gov; registration date 15th June 2017 https://clinicaltrials.gov/ct2/show/study/NCT03188172