The Relevance and Insights on 1,4-Naphthoquinones as Antimicrobial and Antitumoral Molecules: A Systematic Review

Natural product derivatives are essential in searching for compounds with important chemical, biological, and medical applications. Naphthoquinones are secondary metabolites found in plants and are used in traditional medicine to treat diverse human diseases. Considering this, the synthesis of napht...

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Published inPharmaceuticals (Basel, Switzerland) Vol. 16; no. 4; p. 496
Main Authors Navarro-Tovar, Gabriela, Vega-Rodríguez, Sarai, Leyva, Elisa, Loredo-Carrillo, Silvia, de Loera, Denisse, López-López, Lluvia Itzel
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 27.03.2023
MDPI
Subjects
Antibacterial agents
antimicrobial
Antimitotic agents
Antineoplastic agents
antitumoral
bioactive secondary metabolites
Biological activity
Cancer
Chemical properties
Chemistry
Health aspects
Malaria
naphthoquinones
Natural products
Nitrogen
Pharmaceutical sciences
Plant metabolites
Review
Testing
Mexico
antimicrobial
naphthoquinones
antitumoral
bioactive secondary metabolites
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Summary:Natural product derivatives are essential in searching for compounds with important chemical, biological, and medical applications. Naphthoquinones are secondary metabolites found in plants and are used in traditional medicine to treat diverse human diseases. Considering this, the synthesis of naphthoquinone derivatives has been explored to contain compounds with potential biological activity. It has been reported that the chemical modification of naphthoquinones improves their pharmacological properties by introducing amines, amino acids, furan, pyran, pyrazole, triazole, indole, among other chemical groups. In this systematic review, we summarized the preparation of nitrogen naphthoquinones derivatives and discussed their biological effect associated with redox properties and other mechanisms. Preclinical evaluation of antibacterial and/or antitumoral naphthoquinones derivatives is included because cancer is a worldwide health problem, and there is a lack of effective drugs against multidrug-resistant bacteria. The information presented herein indicates that naphthoquinone derivatives could be considered for further studies to provide drugs efficient in treating cancer and multidrug-resistant bacteria.
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ISSN:1424-8247
1424-8247
DOI:10.3390/ph16040496