Potential use of corneal confocal microscopy in the diagnosis of Parkinson’s disease associated neuropathy

Abstract Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disease affecting about 2–3% of population above the age of 65. In recent years, Parkinson’s research has mainly focused on motor and non-motor symptoms while there are limited studies on neurodegeneration which is associa...

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Bibliographic Details
Published inTranslational neurodegeneration Vol. 9; no. 1; pp. 1 - 28
Main Authors Che, Ning-Ning, Yang, Hong-Qi
Format Journal Article
LanguageEnglish
Published London BioMed Central 02.07.2020
BMC
Subjects
Age
Automation
Cornea
Corneal confocal microscopy
Diabetes
Diabetic neuropathy
Lasers
Microscopy
Morphology
Parkinson's disease
Pathogenesis
Peripheral neuropathy
Quality of life
Researchers
Review
Small fiber neuropathy
Software
Studies
Systemic diseases
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Summary:Abstract Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disease affecting about 2–3% of population above the age of 65. In recent years, Parkinson’s research has mainly focused on motor and non-motor symptoms while there are limited studies on neurodegeneration which is associated with balance problems and increased incidence of falls. Corneal confocal microscopy (CCM) is a real-time, non-invasive, in vivo ophthalmic imaging technique for quantifying nerve damage in peripheral neuropathies and central neurodegenerative disorders. CCM has shown significantly lower corneal nerve fiber density (CNFD) in patients with PD compared to healthy controls. Reduced CNFD is associated with decreased intraepidermal nerve fiber density in PD. This review provides an overview of the ability of CCM to detect nerve damage associated with PD.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:2047-9158
2047-9158
DOI:10.1186/s40035-020-00204-3