Topography-guided corneal surface laser ablation combined with simultaneous accelerated corneal collagen cross-linking for treatment of keratoconus

• Published in: BMC ophthalmology Vol. 21; no. 1; pp. 1 - 286
• Main Authors: Zhang, Yu, Chen, Yueguo
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 24.07.2021; BioMed Central; BMC
• Subjects: Ablation; Accelerated; Acuity; Asymmetry; Care and treatment; Collagen; Coma; Contact lenses; Cornea; Corneal collagen cross-linking; Cross-linking; Keratoconus; Laser ablation; Lasers; Microscopy; Ophthalmology; Refraction; Software; Statistical analysis; Surgery; Tomography; Topography; Topography-guided; Ultraviolet radiation; United States > US; Japan
• ISSN: 1471-2415; 1471-2415
• DOI: 10.1186/s12886-021-02042-x

Abstract Background to study the outcomes of topography-guided customized excimer laser subepithelial ablation combined with accelerated CXL for progressive keratoconus. Methods Thirty-one eyes of 30 patients with progressive keratoconus were included in this prospective study. Topography-guided excimer laser ablation without refractive correction was performed. Simultaneous accelerated collagen cross-linking with ultraviolet light of 30 mW/cm 2 for 4 min was followed. Uncorrected distance visual acuity (UCVA), manifest refraction, corrected distance visual acuity (CDVA), tomograghy were examined at postoperative 1, 6, and 12 months. Results UDVA improved slightly after surgery ( P  > 0.05). BSCDVA improved significantly from 0.32 ± 0.20 logMAR to 0.15 ± 0.14 logMAR at postoperative 12 months ( P  < 0.05). During 12-month follow-ups, there were no significant differences in manifest refraction and corneal keratometry except for maximal keratometry value of the anterior surface (K apex ), which decreased significantly from 57.23 ± 5.09D to 53.13 ± 4.47D ( P  < 0.05). Even though the thinnest corneal thickness decreased from 465 ± 24 μm to 414 ± 35 μm ( P  < 0.05), curvature asymmetry index front (SIf), keratoconus vertex front (KVf) and Baiocchi Calossi Versaci index front (BCVf) decreased significantly till postoperative 12 months ( P  < 0.05). Corneal higher-order aberrations and coma also decreased significantly till 12 months after surgery ( P  < 0.05). Conclusions Topography-guided surface ablation without refractive correction combined with simultaneous accelerated collagen cross-linking provided good stability in refraction and corneal curvature, and also showed significant improvement in BSCDVA, corneal regularity and corneal optical quality.