Role of glycosyltransferases in carcinogenesis; growth factor signaling and EMT/MET programs

• Published in: Glycoconjugate journal Vol. 39; no. 2; pp. 167 - 176
• Main Authors: Takahashi, Motoko, Hasegawa, Yoshihiro, Maeda, Kento, Kitano, Masato, Taniguchi, Naoyuki
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2022; Springer Nature B.V
• Subjects: Biochemistry; Biomedical and Life Sciences; Carcinogenesis; Cell surface; Dimerization; Endocytosis; Glycosylation; Glycosyltransferases - metabolism; Humans; Intercellular Signaling Peptides and Proteins; Life Sciences; Mini Review; N-Acetylglucosaminyltransferases - metabolism; N-glycans; Pathology; Phosphorylation; Polysaccharides; Protein transport; Signal Transduction; Tribute to Professor Sen-itiroh Hakomori; Fut8; ST6Gal1; EMT programs; Cell surface receptor; Collectin; ErbB receptors; GM3; GnT-III; GnT-V; EGFR
• ISSN: 0282-0080; 1573-4986; 1573-4986
• DOI: 10.1007/s10719-022-10041-3

The glycosylation of cell surface receptors has been shown to regulate each step of signal transduction, including receptor trafficking to the cell surface, ligand binding, dimerization, phosphorylation, and endocytosis. In this review we focus on the role of glycosyltransferases that are involved in the modification of N-glycans, such as the effect of branching and elongation in signaling by various cell surface receptors. In addition, the role of those enzymes in the EMT/MET programs, as related to differentiation and cancer development, progress and therapy resistance is discussed.