Association analyses identify six new psoriasis susceptibility loci in the Chinese population

• Published in: Nature genetics Vol. 42; no. 11; pp. 1005 - 1009
• Main Authors: Zhang, Xue-Jun, Sun, Liang-Dan, Cheng, Hui, Wang, Zai-Xing, Zhang, An-Ping, Wang, Pei-Guang, Xu, Jin-Hua, Zhu, Qi-Xing, Zhou, Hai-Sheng, Ellinghaus, Eva, Zhang, Fu-Ren, Pu, Xiong-Ming, Yang, Xue-Qin, Zhang, Jian-Zhong, Xu, Ai-E, Wu, Ri-Na, Xu, Li-Min, Peng, Lin, Helms, Cynthia A, Ren, Yun-Qing, Zhang, Chi, Zhang, Shu-Mei, Nair, Rajan P, Wang, Hong-Yan, Lin, Guo-Shu, Stuart, Philip E, Fan, Xing, Chen, Gang, Tejasvi, Trilokraj, Li, Pan, Zhu, Jun, Li, Zhi-Ming, Ge, Hong-Mei, Weichenthal, Michael, Ye, Wen-Zheng, Zhang, Cheng, Shen, Song-Ke, Yang, Bao-Qi, Sun, Yuan-Yuan, Li, Shan-Shan, Lin, Yan, Jiang, Jian-Hua, Li, Cun-Tao, Chen, Ri-Xin, Cheng, Juan, Jiang, Xin, Zhang, Peng, Song, Wei-Min, Tang, Jin, Zhang, Hao-Qin, Sun, Li, Cui, Jing, Zhang, Li-Jun, Tang, Biao, Huang, Fei, Qin, Qian, Pei, Xiao-Ping, Zhou, Ai-Min, Shao, Li-Mei, Liu, Jian-Lan, Zhang, Feng-Yu, Du, Wei-Dong, Franke, Andre, Bowcock, Anne M, Elder, James T, Liu, Jian-Jun, Yang, Sen
• Format: Journal Article
• Language: English
• Published: New York, NY Nature Publishing Group 01.11.2010
• Subjects: Aminopeptidases - genetics; Asian Continental Ancestry Group - genetics; Biological and medical sciences; Care and treatment; Connexin 26; Connexins - genetics; Data processing; Dermatology; Design; Disease; Disease susceptibility; DNA Replication; Fundamental and applied biological sciences. Psychology; Genetic aspects; Genetic Predisposition to Disease; Genetics; Genetics of eukaryotes. Biological and molecular evolution; Genome-Wide Association Study; Germany - epidemiology; Human; Humans; Independent sample; Medical sciences; Membrane Proteins - genetics; Minor Histocompatibility Antigens; Neoplasm Proteins - genetics; Polymorphism, Single Nucleotide; Population genetics, reproduction patterns; Psoriasis; Psoriasis - genetics; Psoriasis. Parapsoriasis. Lichen; Risk factors; Securin; Serpins - genetics; Single nucleotide polymorphisms; Studies; United States - epidemiology; Asia; China; Far east; Human; Skin disease; Psoriasis; Locus
• ISSN: 1061-4036; 1546-1718
• DOI: 10.1038/ng.690

We extended our previous genome-wide association study for psoriasis with a multistage replication study including 8,312 individuals with psoriasis (cases) and 12,919 controls from China as well as 3,293 cases and 4,188 controls from Germany and the United States and 254 nuclear families from the United States. We identified six new susceptibility loci associated with psoriasis in the Chinese study containing the candidate genes ERAP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A (combined P < 5 × 10−8) and replicated one locus, 5q33.1 (TNIP1-ANXA6), previously reported (combined P = 3.8 × 10−21) in the European studies. Two of these loci showed evidence for association in the German study at ZNF816A and GJB2 with P = 3.6 × 10−3 and P = 7.9 × 10−3, respectively. ERAP1 and ZNF816A were associated with type 1 (early onset) psoriasis in the Chinese Han population (test for heterogeneity P = 6.5 × 10−3 and P = 1.5 × 10−3, respectively). Comparisons with the results of previous GWAS of psoriasis highlight the heterogeneity of disease susceptibility between the Chinese and European populations. Our study identifies new genetic susceptibility factors and suggests new biological pathways in psoriasis.