Risk of breast cancer according to clinicopathologic features among long-term survivors of Hodgkin's lymphoma treated with radiotherapy

• Published in: British journal of cancer Vol. 103; no. 7; pp. 1081 - 1084
• Main Authors: Dores, G M, Anderson, W F, Beane Freeman, L E, Fraumeni, J F, Curtis, R E
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.09.2010; Nature Publishing Group
• Subjects: 692/699/67/1059/485; 692/699/67/1347; 692/699/67/1990/291/1556; 692/700/139/422; Adolescent; Adult; Age; Aged; Aged, 80 and over; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Breast cancer; Breast Neoplasms - epidemiology; Cancer Research; Drug Resistance; Epidemiology; Female; Females; Gynecology. Andrology. Obstetrics; Hodgkin Disease - radiotherapy; Humans; Lymphoma; Mammary gland diseases; Medical research; Medical sciences; Middle Aged; Molecular Medicine; Neoplasms, Radiation-Induced - epidemiology; Neoplasms, Second Primary - epidemiology; Oncology; Radiation therapy; Radiotherapy - adverse effects; Risk Factors; SEER Program; Short Communication; Survivors; Tumors; United States > US; second breast cancer; radiation-related breast cancer; Hodgkin's lymphoma; Breast disease; Survivor; Hodgkin disease; Malignant hemopathy; Breast cancer; Malignant tumor; Radiotherapy; Lymphoma; Long term; Mammary gland diseases; Anatomic pathology; Cancerology; Histopathology; Treatment; Second cancer; Lymphoproliferative syndrome; Risk factor; Cancer
• ISSN: 0007-0920; 1532-1827
• DOI: 10.1038/sj.bjc.6605877

Background: It is unknown whether breast cancer (BC) characteristics among young women treated with radiotherapy (RT) for Hodgkin's lymphoma (HL) differ from sporadic BC. Methods: Using population-based data, we calculated BC risk following HL according to clinicopathologic features. Results: Compared with BC in the general population, risks of oestrogen receptor (ER)-positive/progesterone receptor (PR)-positive and ER-negative/PR-negative BC in young, irradiated HL survivors were increased five-fold (95% confidence interval (CI)=3.81–6.35) and nine-fold (95% CI=6.93–12.25), respectively. Among 15-year survivors, relative risk of ER-negative/PR-negative BC exceeded by two-fold ( P =0.002) than that of ER-positive/PR-positive BC. Conclusion: Radiotherapy may disproportionately contribute to the development of BC with adverse prognostic features among young HL survivors.